Cannabinoid concentrations in hair from documented cannabis users

Fifty-three head hair specimens were collected from 38 males with a history of cannabis use documented by questionnaire, urinalysis and controlled, double blind administration of delta9-tetrahydrocannabinol (THC) in an institutional review board approved protocol. The subjects completed a questionnaire indicating daily cannabis use (N=18) or non-daily use, i.e. one to five cannabis cigarettes per week (N=20). Drug use was also documented by a positive cannabinoid urinalysis, a hair specimen was collected from each subject and they were admitted to a closed research unit. Additional hair specimens were collected following smoking of two 2.7% THC cigarettes (N=13) or multiple oral doses totaling 116 mg THC (N=2). Cannabinoid concentrations in all hair specimens were determined by ELISA and GCMSMS. Pre- and post-dose detection rates did not differ statistically, therefore, all 53 specimens were considered as one group for further comparisons. Nineteen specimens (36%) had no detectable THC or 11-nor-9-carboxy-THC (THCCOOH) at the GCMSMS limits of quantification (LOQ) of 1.0 and 0.1 pg/mg hair, respectively. Two specimens (3.8%) had measurable THC only, 14 (26%) THCCOOH only, and 18 (34%) both cannabinoids. Detection rates were significantly different (p<0.05, Fishers' exact test) between daily cannabis users (85%) and non-daily users (52%). There was no difference in detection rates between African-American and Caucasian subjects (p>0.3, Fisher's exact test). For specimens with detectable cannabinoids, concentrations ranged from 3.4 to >100 pg THC/mg and 0.10 to 7.3 pg THCCOOH/mg hair. THC and THCCOOH concentrations were positively correlated (r=0.38, p<0.01, Pearson's product moment correlation). Using an immunoassay cutoff concentration of 5 pg THC equiv./mg hair, 83% of specimens that screened positive were confirmed by GCMSMS at a cutoff concentration of 0.1 pg THCCOOH/mg hair.     

Writing the Rwandan Genocide: The Justice and Politics of Witnessing after the Event

This paper tries to read together three texts that refer to the Rwandan genocide and to draw attention to certain paradoxes that emerge from the way in which the texts might be said to talk to and past each other. The overall intention is to throw light on the complications in witnessing such an event, and to themes of justice and politics that arise.

Police Occupational Culture: Testing the Monolithic Model*

Since foundational work in the 1950s, researchers have described a variety of dimensions of the occupational culture of police. In an effort to integrate the disparate works, a theoretical model has been constructed depicting the ways in which the stressful features of the police work environment produce coping mechanisms and outcomes. While this model usefully organizes the vast literature on police culture, it has yet to be empirically tested. The current study addresses this void. Path analyses of officer survey data reveal support for several of the propositions set forth by the monolithic model, although the magnitude of the statistical associations was not very powerful and overall model fit was marginal. The implications of these findings are especially relevant given recent concerns over police-community relations and the renewed interest in the police occupational culture expressed by the President’s Task Force on 21st Century Policing.