Assessment of the stability of 30 antipsychotic drugs in stored blood specimens

The accuracy of antemortem diagnosis of pulmonary embolism is within the range of just 10-30%, so representing one of the most frequent missed diagnosis in sudden, unexpected death. We describe 43 fatal cases of pulmonary embolism as confirmed by post-mortem examination. The aim of our study was to verify the systematic search for the most common genetic thrombophilias (Factor V Leiden (G1691A) and FII (G20210A) gene variants) and dating the thrombus. As a whole, 41 patients (95.3%) had at least one risk factor. Pre-existing symptoms are described just before fatal embolism in 18 (41.9%) out 43 patients. In 18 out of 43 (41.9%) it was not possible to find the thrombotic site. In 24 out of the remaining 25 cases the involvement of the deep veins of one leg was shown; in 1 case the thrombus was localised in the inferior caval vein. 10 (41.7%) were iliac vein thromboses, 7 (29.1%) femoral, 2 (8.3%) popliteal, 3 (12.6%) posterior-tibial, 1 (4.1%) anterior-tibial and 1 (4.1%) peroneal vein thromboses. In our cohort of patients, 4 (10%) out of 40 cases carried the 20210A prothrombin gene variant in heterozygosis. One (2.5%) out of 40 carried the Factor V Leiden (G1691A) gene variant in heterozygosis. Patients carrying these gene variants in homozygosis or carrying both were not present in our case-series. We strongly underline the relevance of a complete methodological approach, integrating clinical data by means of autopsy findings and histological study. On the contrary, investigating common inherited thrombophilia is not warranted.     

Provisional Measures: Binding and Persuasive? Enabling Human Rights Adjudicators to Follow up on State Disrespect

Netherlands International Law Review - Given the importance of the rights at stake (the right to life, the prohibition of torture and cruel treatment and the right of individual petition as such)...     

Disproportionality and voter turnout in new and old democracies

A long-standing puzzle in electoral research is why the disproportionality of electoral systems has a negative effect on voter participation in established democracies, but not in new democracies. We propose a learning theory of electoral system’s effects, and test it in a cross-national analysis and by using Spain as a case study. Electoral disproportionality is unrelated to voter participation in early elections after democratization, but the relationship is increasingly visible as democracies grow older. The case study uncovers two mechanisms: small parties optimize their mobilization strategy only after the first democratic elections, and the difference in the turnout rates of small party supporters and large party supporters grows over time. Time is needed before the consequences of electoral systems are fully revealed. Importantly, the findings suggest that studies carried out just after an electoral system is created or reformed may provide downward biased estimates of their long-term consequences.     

Population data for 15 Y-chromosome STRs in a population sample from Quito (Ecuador)

Population frequencies for the 9 Y-STR loci included in the "minimal haplotype" from Y-STR Haplotype Reference Database (YHRD), plus other 6 Y-STRs (DYS437, DYS438, DYS439, GATA A7.2, GATA H4 and GATA A10) were obtained for a sample of 120 males from Quito (Ecuador). One hundred and sixteen unique haplotypes were identified within the sample. Haplotype diversity (0.9994) was among the highest in comparison to other populations from Iberia and South-America. Genetic distances were calculated and our sample presented significative differences with all other samples, the lowest values being with a Guinean sample.     

Legal, Individual, and Environmental Predictors of Court Disposition in a Sample of Serious Adolescent Offenders

Historically, the juvenile court has been expected to consider each youth's distinct rehabilitative needs in the dispositional decision-making process, rather than focusing on legal factors alone. This study examines the extent to which demographic, psychological, contextual, and legal factors, independently predict dispositional outcomes (i.e., probation vs. confinement) within two juvenile court jurisdictions (Philadelphia, Phoenix). The sample consists of 1,355 14- to 18-year-old male and female juvenile offenders adjudicated of a serious criminal offense. Results suggest that legal factors have the strongest influence on disposition in both jurisdictions. For example, a higher number of prior court referrals is associated with an increased likelihood of secure confinement in both jurisdictions. Juveniles adjudicated of violent offenses are more likely to receive secure confinement in Phoenix, but are more likely to be placed on probation in Philadelphia. Race is unrelated to dispositional outcome, but, males are consistently more likely than females to be placed in secure confinement. Importantly, individual factors (e.g., developmental maturity) generally were not powerful independent predictors of disposition. Finally, an examination of the predictors of juvenile versus adult court transfer in Phoenix indicated that males, older juveniles, and those with a violent adjudicated charge were more likely to be transferred to adult court, while juveniles scoring high on responsibility as well as those juveniles with an alcohol dependence diagnosis were more likely to be retained in juvenile court.     

Global democracy and feasibility

ABSTRACT

While methodological and metatheoretical questions pertaining to feasibility have been intensively discussed in the philosophical literature on justice in recent years, these discussions have not permeated the debate on global democracy. The overall aim of this article is to demonstrate the fruitfulness of importing some of the advancements made in this literature into the debate on global democracy, as well as to develop aspects that are relevant for explaining the role of feasibility in normative political theory. This is done by pursuing two arguments. First, to advance the work on the role of feasibility, we suggest as intuitively plausible two metatheoretical constraints on normative political theorizing – the ‘fitness constraint’ and the ‘functional constraint’ – which elucidate a number of aspects relevant in determining proper feasibility constraints for an account in political theory. Secondly, to illustrate the usefulness of this feasibility framework, we sketch an account of global democracy consisting of normative principles which respond differently to these aspects and thus are tied to different feasibility constraints as well as exemplify how it may be applied in practice.     

Lake Taupo: a multi‐sector collaborative partnership towards sustainable development

This paper explores the motivations for and processes of a unique multi‐stakeholder collaboration aimed at the long‐term sustainable development of a region. The region is that of Australasia's largest lake, Lake Taupo, New Zealand. Lake Taupo has geographic features that have not only enabled the development of a strong economy based on tourism, forestry and agriculture but have also generated particular environmental problems. The findings of the case study present highly innovative solutions that are premised on collaboration and on a ‘business case’ for sustainability. From extensive interviews with a wide range of stakeholders, the case confirms extant literature that looks at the roles of leadership, stakeholder engagement, and first movers in bringing about change, but it also highlights further findings that include the surprisingly important role of fringe stakeholders, the difficulties presented by uncertain regulation, and the need to innovate in tailoring solutions to fit the peculiarities of a specific problem. Copyright © 2014 John Wiley & Sons, Ltd.     

How Western Marxism is attempting to survive the collapse of communism in Eastern Europe

She is the author of Fragile Democracy: The Use and Abuse of Power in Western Societiesrecently published by Transaction.