Colchicine poisoning: case report of two suicides

Colchicine overdose is uncommon but potentially life threatening because of the high toxicity of the drug. Poisoning by colchicine may occur following ingestion of medication used in acute attacks of gout and inflammatory diseases. We describe two cases involving suicide by the ingestion of medications marketed in France. In case 1, only heart blood was taken after body external examination. In case 2 an autopsy was performed and heart blood, urine, gastric contents and bile were taken for toxicological analysis. Colchicine was assayed in biological specimens by an HPLC-DAD method, after extraction by dichloromethane at pH 8, adding prazepam as internal standard (IS). Analyses were performed on a Symetry C-8 column. Mobile phase was a gradient of acetonitrile/pH 3.8 phosphate buffer. Colchicine is eluted at 13.1 min and the method is linear for blood, urine and bile over the range 4-1000 ng/mL. LOQ is 4 ng/mL. The concentrations of colchicine detected are: case 1: heart blood 13 ng/mL; case 2: heart blood 66 ng/mL, urine 500 ng/mL, gastric content 12 ng/mL, bile 5632 ng/mL. Our findings are in the range of lethal concentrations previously described, but there is no correlation with the amount of ingested drug. Even after massive overdose, it could be impossible to detect colchicine in blood, and as there is a widespread enterohepatic recirculation before excretion in bile and feces, bile is the target sample to analyse. We conclude in both cases that the cause of death was suicide with colchicine. It appears very important to perform an autopsy in order to obtain bile, urine, heart blood and femoral blood.     

Metric Sex Determination of the Human Coxal Bone on a Virtual Sample using Decision Trees

Decision trees provide an alternative to multivariate discriminant analysis, which is still the most commonly used in anthropometric studies. Our study analyzed the metric characterization of a recent virtual sample of 113 coxal bones using decision trees for sex determination. From 17 osteometric type I landmarks, a dataset was built with five classic distances traditionally reported in the literature and six new distances selected using the two-step ratio method. A ten-fold cross-validation was performed, and a decision tree was established on two subsamples (training and test sets). The decision tree established on the training set included three nodes and its application to the test set correctly classified 92% of individuals. This percentage was similar to the data of the literature. The usefulness of decision trees has been demonstrated in numerous fields. They have been already used in sex determination, body mass prediction, and ancestry estimation. This study shows another use of decision trees enabling simple and accurate sex determination.     

Comment on Kerry D. Vandell's “FHA restructuring proposals: Alternatives and implications”

Abstract

New Orleans, a highly segregated city with low homeownership, experienced a tremendous number of housing foreclosures between 1985 and 1990. This study highlights the process and impact of foreclosure in the urban housing market, which contributes to an understanding of their impact on the spatial structure of the city. Two aspects of foreclosure are examined: the differential impacts of foreclosure on low‐income and African‐American householders and changes in socioeconomic conditions (neighborhood change and the spatial structure of the city) resulting from foreclosure.

Conventional wisdom holds that urban neighborhood transformation is driven largely by white flight. The data presented in this article suggest a counterhypoth‐esis. Middle‐income professional whites employed in businesses impacted by recession who had recently bought housing with high loan‐to‐value ratios were forced to sell or have their houses foreclosed upon. The depressed market, in turn, made such housing affordable to middle‐class blacks interested in homeownership. Thus, black economic opportunity, rather than white flight, dramatically transformed the racial composition of many New Orleans East neighborhoods.     

The Future of Belgian Federalism as Seen Through the Eyes of the Social Partners: A Continuing Obstacle to Social Policy Decentralization?

In this article, we take a look at the discussion on the devolution of social policy. Despite the pressure of strong nationalist movements to decentralize socio-economic matters, the federal welfare state does not erode. In their study up to the early 2000s, Béland and Lecours explain this relative standstill by pointing to the institutionalization of neo-corporatistic organizations. These organizations, which are strongly involved in the management of the welfare state, have not split along language lines and prevent the decentralization of socio-economic policies in order to preserve their power. Based on empirical evidence, this paper shows that federal social partners are an important obstacle to social policy decentralization in Belgium while the regional social partners have differing opinions on the devolution debate.     

The Limits of Studies in Comparative Development of East Asia and Latin America: the case of land reform and agrarian policies

This paper critically examines the widespread belief that the early implementation of comprehensive land reforms prior to the industrialisation process, coupled with subsequent agrarian state policies channelling the intersectoral transfer of resources, has been a central determinant of East Asia's (mainly Taiwan's and South Korea's) outperformance of Latin America. We argue that, although those agrarian policies should certainly be part of any comparative investigation of the course of capitalist development in each of these two regions, they cannot explain their divergence. The paper contends that the respective scope and timing of agrarian policies has been an expression of the specific contradictions of the early industrialisation process in each region, rather than an autonomous determinant of the course of the latter. Based on insights derived from the Marxian critique of political economy, the paper shows that each region's respective agrarian policies have expressed the differential resolution of the opposition between the rate of profit (industrial capital) and ground-rent (landed property) in the import substituting industrialisation process. In so doing, the paper takes issue with the claim that timely land reforms in Taiwan and Korea have facilitated the subsequent successful turn to an export-oriented industrialisation strategy. An alternative account of the different developmental paths in East Asia and Latin America based on the unfolding of the Marxian ‘law of value’ on a world scale is also provided.     

Compensator,Amplifier, or Distractor? The Moderating Role of Informal Political Talk on the Effect of News Media Use on Current-Affairs Learning Among First-Time Voters

With an increasing number of young people turning away from traditional news sources, an important question for democracy is whether alternative sources can help learning about politics and current affairs. In this study, we examine to what extent informal political talk with friends, family, and peers narrows or widens knowledge gaps amongst young people by compensating those with low news media use (“helping the poor”), amplifying news media effects amongst those with high news media use (“the rich get richer”), or distracting those with high news media use (“taxing the rich”). To test these different potentials, we take advantage of a four-wave panel study fielded ahead of the Danish National Election in 2015 among a sample of Danish first-time voters (ages 17 to 21). Our results show that informal political talk functions mostly as a compensator by informing those with low news media use about current political affairs and thereby helps decrease knowledge gaps caused by different levels of news media use.     

Sexual Dimorphism of the Fetal Ilium: A 3D Geometric Morphometric Approach with Multislice Computed Tomography

Adult sexual dimorphism is well established. However, data regarding fetuses are sparse with contradictory results. Our study aimed to look for fetal sexual dimorphism. Multislice computed tomography (MSCT) examinations and three‐dimensional (3D) reconstructions were recorded on 93 fetal iliac bones aged between 21 and 40 weeks of amenorrhea (WA). The collection was divided into two age groups, with a cutoff at 30 WA. The 3D geometric morphometric analysis was based on outline analysis. We used elliptic Fourier analysis (EFA) because of the difficulty of landmark positioning. Step‐by‐step reconstructions allowed a better comprehension of the fine shape details. Principal component analysis (PCA) and linear discriminant analysis (LDA) were performed on the two age groups. Results did not show any difference between male and female shapes, in both age groups. We demonstrate the feasibility of outline analysis for immature shapes, but sexual dimorphism has not been established in our collection.