Probability of exclusion in paternity testing: time to reassess

The average exclusion probability is a measure of efficiency in paternity testing; it refers to the a priori ability of a battery of tests to detect paternity inconsistencies. This parameter measures the capacity of the system to detect a false accusation of paternity. Traditionally, this average exclusion probability has been estimated as the probability of excluding a man who is not the father by an inconsistency in at least one of the studied loci. We suggest that this criterion should be corrected, as currently the presumed father is excluded when at least three genetic inconsistencies are found with the child being tested, not just one. This change of criterion has occurred because of the use of microsatellite loci, whose mutation rates are much greater than those of the coding genes used previously in paternity studies. We propose the use of the average probability of exclusion for at least three loci (not only one), as an honest measure of the combined probability of exclusion of several loci, and we propose an algebraic expression to calculate it.     

Solid-phase microextraction for the determination of cocaine and cocaethylene in human hair by gas chromatography-mass spectrometry

A method for the simultaneous determination of cocaine (COC) and cocaethylene (CE) in human hair was developed, using solid-phase microextraction (SPME) and gas chromatography-mass spectrometry (GC-MS) as analytical technique to identify and quantify the drugs. Selected ion monitoring (SIM) mode was used to obtain higher sensitivity. The deuterated-labeled analogues were used as internal standards. The detector response was linear for the drugs studied over the range 0.4-15 ng/mg, with correlation coefficients higher than 0.995. The coefficients of variation oscillated between 0.65% and 14.18% and the accuracy was in the range from 0.73% to 11.20%. The limits of quantitation and detection were found to be acceptable. Finally, this method was applied to 15 hair samples from cocaine users, obtaining positive results in all cases. The mean concentrations were 5.39 ng/mg (range: 0.43-8.98 ng/mg) for cocaine and 1.11 ng/mg (range: 0.42-2.23 ng/mg) for cocaethylene.     

Genetic variation of 15 STR autosomal loci in the Maracaibo population from Venezuela

Allele frequencies for 15 short tandem repeats (STRs) autosomal loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA, included in the AmpFLSTR Identifiler, Applied Biosystems) were studied in the city of Maracaibo, Venezuela and were compared with other published Latin-American populations for the same loci. Population and forensic parameters were estimated.     

Population genetic data for 18 STR loci in Costa Rica

Allele frequencies for 18 STR autosomal loci (D3S1358, VWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, D16S539, TH01, TPOX, CSF1PO, Penta D, Penta E, D19S433, D2S1338 and SE33) were obtained from a sample of 191-500 unrelated individuals from Costa Rica, Central America.     

Analyzing Concepts of Human Rights with an Asian Accent

Let’s suppose we were in the early Twentieth Century,trying to answer the question:What will be the most important things that will happen in this century?You may think about the"rise of the United States,"or the long-lived British Empire.     

A Critical Analysis of Global Governance vs.Protection and Development of Human Rights

Human rights merit global attention in the current era of globalization.The realization and protection of human rights is an important part of the process of global governance.Meanwhile,global governance     

Clientelism or Something Else? Squatter Politics in Montevideo

Through the in‐depth ethnographic study of one squatter neighborhood in Montevideo and its leader's political networks, this article illustrates a successful strategy through which some squatter neighborhoods have fought for their right to the city. This consists of opportunistic, face‐to‐face relationships between squatter leaders and politicians of various factions and parties as intermediaries to get state goods, such as water, building materials, electricity, roads, and ultimately land tenure. Through this mechanism, squatters have seized political opportunities at the national and municipal levels. These opportunities were particularly high between 1989 and 2004, years of great competition for the votes of the urban poor on the periphery of the city, when the national and municipal governments belonged to opposing parties. In terms of theory, the article discusses current literature on clientelism, posing problems that make it difficult to characterize the political networks observed among squatters.     

东南亚国家的经济外交与地区安全秩序的重塑

冷战结束后,塑造东亚地区安全秩序的力量来源主要有两个:一是雅尔塔体系的遗产,二是东南亚国家的经济外交。一方面,中国与俄罗斯通过上海合作组织构建了在安全等领域的合作,而美国在美日同盟的基础上强化了其在东亚的单边及多边同盟体系。因此,雅尔塔体系遗产的组织化程度较以往明显提高。另一方面,东南亚诸国通过在东盟"10+"合作框架、亚太经合组织以及亚欧会议等平台实施经济外交,比较成功地把主要大国及区域集团力量牵绊在东亚地区,并藉此影响了冷战后东亚地区的政治、安全秩序。