Functioning and Effectiveness of Electronic Control Devices Such as the TASER® M‐ and X‐Series: A Review of the Current Literature

Abstract: Conducted electrical weapons (CEWs) such as the TASER^® M‐ and X‐series deliver short high‐voltage, low‐current energy pulses to temporarily paralyze a person by causing electrical interruption of the body’s normal energy pulses. Despite many scientific publications, which classify the health risks of an appropriate use of the TASER device as minor, there still is a continuous uncertainty about possible side effects with human application. Based on a literature search of the National Library of Medicine’s MEDLINE database’s PubMed system of current publications, the following article describes the mechanisms by which the device operates and discusses possible pathophysiological consequences. The majority of current human literature has not found evidence of clinical relevant pathophysiological effects during and after an exposure of professionally applied CEWs. However, to be able to exclude possible health risks, a medical checkup of people who have been exposed to CEWs is essential.     

Determination of venlafaxine in post-mortem whole blood by HS-SPME and GC-NPD

Venlafaxine is a phenethylamine derivative widely prescribed for the treatment of depression which inhibits both serotonin and norepinephrine reuptake (SNRI). In treatment with antidepressants of patient with depression and other psychiatric disorders there is also increased risk of suicidal thought and behaviour. Several lethal intoxications involving venlafaxine usually among psychotic patients have been reported in the literature. Sample preparation is of the greatest significance for a successful toxicological analysis. The development of simple, effective and rapid extraction procedures of drugs from post-mortem biological samples is a challenge. Headspace-solid phase microextraction (HS-SPME) offers significant advantages such as simplicity, low cost, compatibility with analytical systems, automation and solvent-free extraction. The aim of our work was the optimization of a HS-SPME procedure for the determination of venlafaxine in post-mortem biological samples by gas chromatography (GC) with nitrogen-phosphorous detection (NPD). Venlafaxine was extracted on 100 μm Polydimethylsiloxone Coating-Red (PDMS) SPME fiber and determined by GC-NPD. Salt addition, extraction temperature, preheating and extraction time were optimized to enhance the recovery of the extraction from aqueous solution spiked with venlafaxine. Finally the developed procedure was applied to post-mortem biological samples of a fatally poisoned woman by venlafaxine. The drug was quantified in post-mortem blood gastric and oesophagus contents of the deceased woman. A simple and rapid procedure using HS-SPME was developed for sample preparation of venlafaxine in post-mortem biological samples prior to GC-NPD determination. Validation data was satisfactory, thus enabling application in the toxicological analysis of forensic samples.     

Clozapine--a dangerous drug in a clozapine-naïve subject

Clozapine is a uniquely effective antipsychotic, but is very toxic in clozapine-na?ve subjects. A 34-year-old male patient in a mental health facility, who was not prescribed clozapine, took 350 mg clozapine obtained from another patient at night. He was found dead the next morning. The presence of cardiomegaly related to obesity may have increased the risk of suffering an acute cardiac event after ingestion of clozapine. The medication prescribed to the patient was not thought to have contributed to the fatal outcome. Post mortem femoral blood clozapine and norclozapine concentrations were 0.48 and 0.20mg/L, respectively. By way of comparison, audit of 104,127 plasma samples (26,796 patients) assayed for therapeutic drug monitoring purposes 1993-2007, showed plasma clozapine 0.35 mg/L or more in 57.5% samples (8.4% 1mg/L or more). Those involved in the investigation of clozapine-associated deaths need to be aware that that death in an adult may occur after a single 'therapeutic' dose. A diagnosis of fatal clozapine poisoning cannot be made solely on the basis of a post mortem blood clozapine measurement.     

The terrorists' dilemmas: Some implicit rules of the game 1

Abstract

Knowledge of certain dilemmas faced by terrorists may serve to narrow the options available to the opposing parties and aid in varying government response to terrorist acts. Such dilemmas are the identification with violence, the problem of attacking or seeking a negotiated incident, choice of level of terror, maintenance of one's objectivity within a group characterized by conformity, and retaining one's identity as a historic victim.     

A critical geography of poverty finance

This paper builds a critical geography of poverty finance with recourse to a relational comparison of the microfinance and subprime mortgage markets. It probes paradoxical claims about the nature of poverty, the poor, states and markets that have surfaced in the aftermath of the financial crisis. In doing so it aims to generate new understandings of neoliberal global finance with specific emphasis on 1) the social constitution of risk through racialised and gendered forms of difference; 2) the exercise of dispossession and imperialism by financial means; and 3) articulations of poverty finance with the social relations of debt in specific conjunctures. Each of these terrains of inquiry forms a subsection of the paper, following a preliminary section that poses the animating paradox in more detail. The paper concludes with some reflections on the conditions of possibility for democratising finance.     

THE STUDY OF PUBLIC ADMINISTRATION IN THE UNITED STATES

The study of public administration in the United States is large in terms of the number of academic programmes, the range of journal publications, and the number of scholars. Its scholarship attracts attention from all over the globe. At the same time it is a public administration that is clearly embedded in a specific national culture, just as anywhere else. Three of the main challenges include the strong increase of quantitative‐statistical methods, the decline of practitioner authors, and substantive specialization to the extent that generalists' perspectives are losing ground.     

CAREFUL COMMITMENT

New avenues to be explored for Belt and Road cooperation At the beginning of 2021,the situation looks better in China and the rest of the world.China is striving to maintain its success in eliminating COVID-19 cases domestically and fostering immunity for its 1.4-billion population.The more the vaccination process gains ground,the more it is likely that lives will return to normalcy.     

Replication Studies of Development Impact Evaluations

Six years ago, the International Initiative for Impact Evaluation (3ie) launched a programme to promote and fund replication studies of impact evaluations in international development. We designed the programme with the objective of improving the quality of evidence for development policy-making, using replication research to both validate the results of published impact evaluations and build the incentives for more transparent and high quality research going forward. The programme’s focus is internal replication, which uses the original data from a study to address the same question as that study. This Journal of Development Studies special issue compiles the majority of completed 3ie-funded replication studies initiated in the first years of the programme. In all cases the pure replication components of these studies are generally able to reproduce the results published in the original article. Most of the measurement and estimation analyses confirm the robustness of the original articles or call into question just a subset of the original findings. These replication studies mostly focus on providing additional information about the impacts of the interventions – especially additional information that can be important for interpreting the articles for the purpose of policy-making.