Cocaine‐Induced Intracerebral Hemorrhage in a Patient with Cerebral Amyloid Angiopathy*

Abstract: Intracerebral hemorrhage (ICH) is a well‐recognized complication of recreational cocaine use. The precise mechanism of the cocaine‐induced hemorrhagic event is unclear, although multiple factors have been implicated. We report a case of a 62‐year‐old woman who suffered left parieto‐occipital ICH with herniation and death, following a cocaine binge. Microscopic examination also revealed extensive cerebral amyloid angiopathy (CAA) in the vicinity of the hemorrhage. We additionally studied brain tissue in eight subjects between ages of 60 and 80 who were positive for cocaine metabolites at autopsy; of these, none had vascular amyloid‐β deposits by immunohistochemistry. Whereas we found no evidence that chronic cocaine use is a risk factor for CAA, given the age‐associated nature of CAA and the aging population using cocaine, CAA‐induced hemorrhage in the setting of cocaine use may be more common than recognized. This is the first reported case of CAA‐associated ICH precipitated by cocaine.     

A test of the effectiveness of speaker verification for differentiating between identical twins

This paper presents investigations into the ability of speaker verification technology to discriminate between identical twins. It is shown that whilst, in general, the genetic and non-genetic characteristics of voice are both of value to speaker verification capabilities, it is the latter which is highly beneficial in the separation of the speech of identical twins. It is further demonstrated that through the use of unconstrained cohort normalisation as a complementary means for the exploitation of such voice characteristics, the verification reliability can be considerably enhanced for both identical twins and unrelated speakers. Experiments were conducted using a bespoke clean-speech database consisting of utterances from 49 identical twin pairs. The paper details the problem in speaker verification posed by identical twins, discusses the experimental investigations and provides an analysis of the results.     

Factors influencing help-seeking from informal networks among African American victims of intimate partner violence

The purpose of this study was to gain an understanding of the challenges African-American women in abusive relationships face when they consider seeking-help from their informal networks. Data are reported from interviews with 15 African-American women who were self-identified as having survived physical intimate partner violence. A 13-item, semi-structured interview guide was developed in order to elicit information from participants. All of the interviews were audio-recorded, transcribed, and coded for analysis. This analysis revealed emergent themes from these interviews concerning the social factors and perceptions that influence help-seeking behavior. Participants perceived their informal networks as willing to offer instrumental support. However, informal networks were not emotionally supportive. Participants also noted that the African-American community at-large believes victims of violence to be "stupid" for remaining in violent relationships. Additional results are also discussed. Results may be used to help enhance efforts to reduce the rates of intimate partner violence among African-Americans.     

The dynamics of illicit drugs production: Future sources and threats

This paper examines the opportunities for illicit drugs production which arise out of the economic, political and social conditions of some countries. These drivers can help us to understand the geographical pattern of global drugs sources and assist in the process of identifying those parts of the world in which new production opportunities are arising. It was found that there is not a homogenous set of risks which contributes to drugs production. Instead, the particular contexts which are conductive to drug production activities varies for different drug types. This has influenced the different patterns of drugs production for highly refined, organic drugs, such as cocaine and heroin, compared to synthetic drugs. The nature of developments which could trigger new areas of drug production are discussed. This revised version was published online in July 2006 with corrections to the Cover Date.     

Law Is the Command of the Sovereign: H. L. A. Hart Reconsidered

This article presents a critical reevaluation of the thesis—closely associated with H. L. A. Hart, and central to the views of most recent legal philosophers—that the idea of state coercion is not logically essential to the definition of law. The author argues that even laws governing contracts must ultimately be understood as “commands of the sovereign, backed by force.” This follows in part from recognition that the “sovereign,” defined rigorously, at the highest level of abstraction, is that person or entity identified by reference to game theory and the philosophical idea of “convention” as the source of signals with which the subject population has become effectively locked, as a group, into conformity.     

Crime in Ireland north and south: Feuding gangs and profiteering paramilitaries

This paper provides a systematic overview of the emergence of organized crime in the Republic of Ireland and Northern Ireland since the late 1960s. It draws on two major studies of organized crime in the South (Hourigan 2011) and paramilitary activity in the North (Morrison 2014) to explore how conflict within and between organized criminal and paramilitary groups, shapes the distinctive dynamic of organized crime on the island of Ireland. The paper opens with an overview of the development of the drugs trade in the Republic of Ireland. The distinctive cultural characteristics of Irish organized crime groups are considered and the role played by paramilitary groups in criminal networks, North and South, is reviewed. As part of this analysis, the dynamic of inter-gang feuds and the spectrum of conflicts between organized criminal and paramilitary groups are analyzed. The competitive and mutually beneficial links between these organizations, North and South are explored as well as the tendency of paramilitaries to engage in vigilantism against criminals (mostly drugs dealers) as a means of building political capital within local communities.