Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood

The stability of two benzisoxazole antipsychotics was determined in vitro in decomposing porcine blood inoculated with bacteria, utilizing a high‐performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and paliperidone were conducted at 7, 20 and 37°C for 4 days using sterile and bacterially inoculated porcine blood. The drugs were stable in sterile blood at each temperature and in inoculated blood at 7°C, but degraded significantly in inoculated blood at 20 and 37°C. Complete loss occurred within 2 days when incubated at 37°C. The benzisoxazole‐cleaved degradation products for both drugs were identified as 2‐hydroxybenzoyl‐risperidone and 2‐hydroxybenzoyl‐paliperidone utilizing liquid chromatography quadrupole‐time‐of‐flight mass spectrometry and accurate mass measurements. The degradation products have been found in postmortem case studies, including one case where risperidone and paliperidone were not detected, indicating complete conversion can occur in situ.     

Analyzing Forensic Evidence Based on Density with Magnetic Levitation

This paper describes a method for determining the density of contact trace objects with magnetic levitation (MagLev). MagLev measurements accurately determine the density (±0.0002 g/cm³) of a diamagnetic object and are compatible with objects that are nonuniform in shape and size. The MagLev device (composed of two permanent magnets with like poles facing) and the method described provide a means of accurately determining the density of trace objects. This method is inexpensive, rapid, and verifiable and provides numerical values—independent of the specific apparatus or analyst—that correspond to the absolute density of the sample that may be entered into a searchable database. We discuss the feasibility of MagLev as a possible means of characterizing forensic‐related evidence and demonstrate the ability of MagLev to (i) determine the density of samples of glitter and gunpowder, (ii) separate glitter particles of different densities, and (iii) determine the density of a glitter sample that was removed from a complex sample matrix.     

John Locke’s America

This essay argues that John Locke’s thought has been a significant influence on how Americans understand public life and that this remains true despite contemporary conservative arguments that Progressivism is ascendant while our Lockean founding is in retreat. Many of the things conservatives bemoan—same-sex marriage, for example—can be understood in Lockean terms. Moreover, Lockean individualism can be consistent with a robust sense of community. Yet it is striking that a most Lockean virtue—responsibility—is altogether missing from critical accounts of Locke’s influence on American politics and culture.     

A Review of: “Audrey Kurth Cronin and James M. Ludes, (eds.). Attacking Terrorism: Elements of a Grand Strategy.”

Because of its dynamic nature, those confronting the al-Qaeda threat must follow its evolution very closely. As demonstrated here, this task is particularly challenging when counterterrorism is carried out under the aegis of international organizations. This article explores the threat identification function of the al-Qaeda Sanctions Committee (also known as the 1267 Committee) charged with supervising the UN sanctions regime against al-Qaeda and its associates. Examination of the role of threat identification in the committee's work, and of the content of the threat analysis presented in the periodic reports of its subsidiary monitoring team, suggests the marginality of strategic threat assessment and underscores the constraints created by bureaucratic and political factors. The article also demonstrates the failure of the Committee and the monitoring team to thoroughly engage in central questions regarding al-Qaeda's nature, objectives, and organizational strategy.     

A Review of: “Fred Schreier. WMD Proliferation: Reforming the Security Sector to Meet the Threat.”

ABSTRACT

Previous research has argued that political inequality between ethnic groups increases the likelihood of both nonviolent and violent protest. In this study, I focus on civil resistance campaigns and argue that the probability that these large-scale, organized movements will take violent over nonviolent forms increases with the share of a country’s population that is excluded from political power on the basis of ethnic affiliation. I expect this to be so because ethnically exclusive regimes are more likely to counter political demands with violent repression, which increases the cost and decreases the anticipated success of nonviolent relative to violent resistance. I test this proposition in a global sample of countries for the period 1950–2006 and find, first, that high levels of ethnic exclusion make civil resistance campaigns more likely to occur violently than nonviolently. Next, to assess the mechanism at play, I conduct a mediation analysis and show that almost half of the effect of ethnic exclusion on violent campaign onset is mediated by the latent level of violent repression in a country. This result suggests that political authorities’ repressive strategies are key to explaining why regime opponents do not always opt for nonviolent forms of civil resistance.