Fatal Folic Acid Toxicity in Humans

Folic acid is B‐9 vitamin. Folic acid is prescribed commonly for pregnant women to prevent neural tube defects in the fetus, patients under chemotherapy, pernicious anemia and to reduce the risk of stroke and cardiovascular disease. Acute or chronic ingestion of a large dose of folic acid generally manifests as neurological complications, which are reversible. In this present case, a 23‐year‐old pregnant woman committed suicide by consuming folic acid tablets and succumbed to death within 36 h. Postmortem toxicological analysis detected folic acid in viscera. Death following acute consumption of folic acid is rare and has been not reported in the literature, to the best of our knowledge.     

Estimation of postmortem interval (PMI) as revealed through the analysis of annual growth in woody tissue

The discovery of human remains lying across a black spruce (Picea mariana) leader (branch) that subsequently grew up around the remains provided an opportunity to use the growth ring pattern to estimate the postmortem interval (PMI). As these remains were discovered in an advanced state of decomposition in October of 2000, and it was clear that relevant insect evidence was not forthcoming, this novel approach to estimating PMI was proposed. The asymmetrical growth of the leader resulted in a correspondingly asymmetrical pattern of its growth riings. As the date of cutting the leader was known, it was possible to evaluate the asymmetrical growth pattern to provide an estimation of PMI. Fine polishing of the cross section and computerized quantification of ring widths enabled an estimation of the displacement of the leader, and hence the time the decedent's body was so positioned. By charting the ring-width differential for the leader, it was concluded that the displacement occurred sometime between July of 1993 and May of 1994. The actual date of disappearance was confirmed to be August 24, 1993.     

Characterization and validation studies of powerPlex 2.1, a nine-locus short tandem repeat (STR) multiplex system and penta D monoplex

In order to increase the power of discrimination for human identification purposes, a nine-locus short tandem repeat (STR) multiplex, the GenePrint PowerPlex 2.1 system (PowerPlex 2.1) developed by Promega Corporation and a separate pentanucleotide-repeat locus, Penta D, were tested. This megaplex system includes the highly polymorphic loci FGA, TPOX, D8S1179, vWA, Penta E, D18S51, D21S11, TH01, and D3S1358 and may be used in combination with the eight-locus STR multiplex, the GenePrint PowerPlex 1.1 system (PowerPlex 1.1) that has been previously developed. Three of the loci, TPOX, TH01 and vWA, have been included in both systems for quality control purposes. As with PowerPlex 1.1, PowerPlex 2.1 is also based on a two-color detection of fluorescent-labeled DNA products amplified by polymerase chain reaction (PCR) and provides a valuable tool for accurate and rapid allele determination. The primer sequences used in the PowerPlex 2.1/Penta D system are also presented in this report. To meet the "Quality Assurance Standards for Forensic DNA Testing Laboratories" (FBI), we tested the efficiency and reproducibility of the PowerPlex 2.1/PentaD system by several validation studies that were conducted as a joint project among seven laboratories. Validation tests included concordance studies, sensitivity, and species specificity determination, as well as performance in forensic and environmentally impacted samples. The results produced from these tests demonstrated the consistency and reliability of the PowerPlex 2.1/Penta D system.     

The state of electroconvulsive therapy in Texas. Part I: reported data on 41,660 ECT treatments in 5971 patients

The Texas Legislature in 1993 mandated a quarterly reporting requirement for hospitals and physicians performing electroconvulsive therapy (ECT) in the state (United States Government hospitals were excluded). The Texas Department of Mental Health and Mental Retardation (TDMHMR) was designated as the agency responsible for collecting and maintaining the data. This paper reviews the ECT data from 16 quarterly reports (09/01/93 through 08/31/97). The reports contained data on 41,660 ECT treatments in approximately 5971 patients. The results of this study support the proposition that ECT is an extremely safe and effective treatment for those individuals suffering from a serious mental illness. In Texas, ethnic groups other than non-Hispanic Anglo-Americans appear to be underserved in regards to ECT. Those patients without appropriate insurance or adequate personal finds are also underserved as a result of the few county and state hospitals performing ECT and the relatively small number of patients treated with ECT at those hospitals. Recommendations are suggested to improve the quality of the database and in informing the public as to the safety and efficacy of this valuable treatment modality. What, at first, was seen as an unwarranted legislative foray into the practice of medicine, has, in the end, become a source of valuable data supporting the use of ECT as an important treatment modality.     

Sleeping With Your Friends' Enemies: An Explanation of Sanctions-Busting Trade

Research indicates that if third parties provide assistance to sanctioned states, the sanctions are less likely to be successful. However, the scholarship on the profile of sanctions busters and their motivations remains underdeveloped. Drawing on the realist and liberal paradigms, this piece develops two competing theories to account for third-party sanctions-busting. The hypotheses drawn from these theories build upon existing work on sanctions, the political determinants of international trade, and the effects of indirect interstate relationships. A quantitative analysis develops a new measure to identify sanctions-busting behavior for a dataset covering 77 sanctions cases from 1950 to 1990. The liberal and realist explanations are then tested. The results offer strong support for the liberal theory of sanctions-busting and less support for the realist theory. In particular, the analysis reveals a counter-intuitive finding that a sender's close allies are more likely to sanctions-bust on the target's behalf than are other states.