低氧和氧化应激中 NO介导培养神经元损伤机理的实验研究

目的探讨低氧、氧化应激中一氧化氮（NO）和氧自由基之间关系及其对培养神经元的损伤机理。方法对培养的新生大鼠神经细胞分别进行低氧、H2O2氧化应激处理和超氧化物歧化酶（SOD）抗氧化应激处理,用比色法等检测培养上清液中NO、丙二醛（MDA）、乳酸脱氢酶（LDH）和SOD含量变化指标。结果与对照组比较,低氧组和H2O2组的NO、LDH、MDA含量均显著增高,SOD含量显著降低,NO与SOD含量变化呈负相关关系。预先给予终浓度为200U/ml的SOD处理,可使神经细胞的NO、LDH和MDA释放量明显减少。各组间NO含量与LDH、MDA含量呈正相关关系。结论低氧、氧化应激促使神经元NO产生增多,NO有增加氧自由基对神经细胞的损伤作用。SOD具有清除氧自由基和减轻NO对神经元的损伤作用。     

唾液酯酶多态性在个体识别中的应用研究

目的 探讨唾液酯酶（ Set）多态性在法医学亲权鉴定和个体识别方面的应用价值。方法 应用聚丙烯酰胺凝胶盘状电泳及固蓝 RR染色方法,调查了 114名中国人 Set的表型分布及基因频率,用χ 2检验进行统计学分析。结果 中国人酯酶表型频率 Set F 22.81％, Set FS 50.88％, Set S 26.31％ ;基因频率为 SetF 0.482 5, SetS 0.517 5;非父排除机率为 0.187 5,个体识别率为 0.619 9。结论 Set有较高的父权排除率和个体识别率,可作为法医学亲权鉴定和个体识别的重要标记系统之一。     

线粒体 DNA突变与心肌病关系的研究进展

人类某些疾病与线粒体DNA(mtDNA)基因组缺陷有关.本文就mtDNA突变与缺血性心肌病和肥厚型心肌病关系的研究加以回顾.目前的研究大多认为心肌缺血缺氧致氧化磷酸化紊乱,产生氧自由基损伤mtDNA,以及缺氧致氧化磷酸化过度诱导而损伤mtDNA,慢性损伤积累终致mtDNA片断缺失或点突变,主要表现出mtDNA5.0kb、7.4kb缺失及细胞色素b(cytb)基因上C15452A点突变;tRNA基因保守序列突变,致肌肉收缩蛋白合成缺陷,缺陷的收缩蛋白持续而无效的收缩可能会增加心肌对ATP的代谢需求,因此导致心肌肥厚.     

邓小平对毛泽东统战理论的新发展及其时代特征

新时期邓小平在关于统一战线的性质和范围、关于知识分子地位和作用、关于多党合作和政治协商制度、关于"一国两制"与和平统一方针等方面对毛泽东统战理论作出新的发展,表现出邓小平统战理论具有鲜明的时代特征,即创造性、科学性、可行性、原则性、灵活性、广泛性.     

Initiation of formal death investigation procedures among the Northern Plains Indians: a necessary adjunct in the study of American Indian sudden infant deaths

The high rate of infant mortality among native peoples in the Aberdeen Service Area of the Indian Health Service (primarily North and South Dakota) prompted a multi-institutional study of this problem. The study investigators assumed that local coroners or medical examiners would be able to perform suitable death scene investigations. However, during the design portion of the study it became apparent that, with one exception, none of the participating Indian Nations had a death investigator or even a legal mandate to provide death investigation. To allow the study to go forward, and ultimately to better the community health within its service area, the Aberdeen Area Indian Health Service submitted a draft enabling coroner legislation/resolutions to the area tribes. By November of 1996, 6 of the 19 Indian Nations enacted enabling coroner legislation. To facilitate both the study and general death investigation within the area, the Aberdeen Area Indian Health Service since 1993 has held five 2-day death investigation training programs covering a variety of death investigation topics which were attended by 68 participants. Without further recognition of the need for tribal death investigation and additional funding, these gains in tribal death investigation will probably be transitory.     

Using the good cop/bad cop profile with the MMPI-2

The Minnesota Multiphasic Personality Inventory (MMPI) has been widely used in a variety of ways to screen candidates for law enforcement positions. This study extends the use of the MMPI Good Cop/Bad Cop (GC/BC) profile (Blau, Super, & Brady, 1993) to the MMPI-2. The MMPI-2 profiles of 39 veteran police officers were used to predict their performance (No Apparent Problems, Borderline, or Serious Problems Possible), and these predictions were compared with supervisors’ ratings of the officers’ actual performance. The MMPI-2 predictions were accurate for 46% of the officers, a rate that was significantly better than chance (p=.024). Based on the current data, the best selection outcome would be obtained by accepting officers whose MMPI-2 profiles place them in the No Apparent Problems or Borderline groups, and rejecting officers whose profiles suggest Serious Problems Possible. This could be accomplished simply by rejecting any officer who obtained a score above 65T on any of the clinical scales. This selection strategy would have resulted in the acceptance of 22 officers, 19 of whom were highly rated by their supervisors, and the rejection of 17 officers, 11 of whom were rated as borderline or poorer by their supervisors. It would also result in the erroneous rejection of 6 officers who were highly rated by supervisors. AUTHOR NOTE: An earlier version of this paper was presented at the 1994 annual meeting of the Society for Police and Criminal Psychology, in Roswell, New Mexico. The authors wish to thank Jim Herndon, Ph.D., for this comments on this study.     

Mediators of the Relation Between Beliefs in a Just World and Emotional Responses to Negative Outcomes

Research shows that strong believers in a just world respond with less negative and more positive emotion to their own negative outcomes than do weak believers. The present study investigated mediators of this relation. We proposed that strong believers in a just world (versus weak believers) would make stronger internal and weaker external attributions for their negative outcomes, leading to reduced perceived unfairness, which, in turn, was expected to lead to less negative and more positive emotion. We assessed the just world beliefs of a sample of undergraduates as well as measuring their cognitive and emotional responses to an exam grade. Mediational analyses showed that our data were consistent with the processes proposed above. Various cognitive and motivational interpretations of the present findings are discussed     

A comparative evaluation of a new generation jail

This study reports findings from an evaluation of a new generation jail in a large southwestern state. The jail is one component of a complex containing a traditional jail, an indirect supervision facility (barracks), and the new generation jail. Using survey and operational data, we compare the new generation jail to the other two facilities. The findings provide generally positive support for the effectiveness of the new generation jail. Inmates and staff were much more satisfied with the physical facilities. Staff perceived it as more secure, though they reported only limited advantages in safety and security. Violence and disciplinary problems were substantially lower. However, no savings in staffing levels were noted, nor were there differences in job satisfaction for staff in the new generation jail. We discuss the implications of the findings and suggest additional directions for jail evaluations.