Evaluating the sensitivity,stability, and cross-reactivity of commercial fentanyl immunoassay test strips

Illicit fentanyl has flooded the United States' drug market, increasing the risk of overdose and poisonings throughout the general population and accidental exposure among law enforcement officers confiscating the increasing number of seizures. Fentanyl test strips (FTS) are used to obtain presumptive information about the presence of fentanyl in a suspected sample. However, their adoption by law enforcement personnel and seized-drug analysts has been limited because most products are advertised for urine testing, not for assays using water solutions. This study presents an evaluation of four commercial FTS: Rapid Response from BTNX, Inc.; T-Dip Fentanyl (FTY) Urine Dip Cards obtained from Amazon.com ; Premier BioDip FYL10 from Premier Biotech Inc.; and MobileDetect Fentanyl strips from DetectaChem, Inc. Performance characteristics curves were used to compare the products' sensitivity, showing that all can reliably detect fentanyl in aqueous solutions at concentrations below 1 μg/mL, with some of the tests able to reliably detect the drug at 200 ng/mL. A stability study demonstrates the performance of all four FTS brands was only slightly affected after 30 days of storage at two extreme environmental conditions. Fentanyl-related substances are also evaluated using the Rapid Response FTS, which showed high cross-reactivity with para-fluorofentanyl and acetylfentanyl, but lower with ortho-chlorofentanyl, carfentanil, and 4-ANPP. Users should be aware that FTS may give false-negative results even when potentially dangerous levels of carfentanil are present. When testing other common drugs, adulterants, and diluents frequently encountered in seized tablets, concentration-dependent results were obtained and multiple instances of false positives were recorded.     

Crime Continuity and Psychological Inertia: Testing the Cognitive Mediation and Additive Postulates with Male Adjudicated Delinquents

Objectives

Crime continuity is one of the best documented and least understood aspects of criminal behavior. Psychological inertia, the notion that cognitive variables mediate the relationship between earlier and later expressions of the same behavior, was tested as a possible explanation for crime continuity.

Methods

The cognitive mediation and additive postulates of the psychological inertia theorem were tested in a path analysis using self-report data from 1170 male delinquent members of the Pathways to Desistance study (Mulvey in Paper presented at the American Society of Criminology Annual Meeting, Chicago, IL, 2012). Wave 1 delinquency served as the independent variable, Wave 3 delinquency served as the dependent variable, Wave 2 outcome expectancies for crime, self-efficacy, general criminal thinking, and social capital served as the mediator variables, and 12 different baseline measures from criminological theory served as control variables in this study.

Results

General criminal thinking and low self-efficacy successfully mediated the relationship between past and future offending after age, race, early behavioral problems, peer criminality, family criminality, parental knowledge and monitoring, parental hostility, routine activities, measured intelligence, and precursors for each of the mediators were controlled. Social capital (cumulative disadvantage), by comparison, failed to mediate crime continuity in this study.

Conclusions

Effective cognitive mediation of the relationship between Wave 1 offending and Wave 3 offending and evidence that the effect may be additive offer preliminary support for the cognitive mediation and additive postulates of the psychological inertia theorem. Practical implications of these results include the need to routinely assess cognitive factors in criminal populations and target these factors for intervention.

     

University mission and academic freedom: Are they irreconcilable?

Educational freedom, rightly understood, depends upon the freedom to shape - and (for individuals) to choose to study in or teach in - distinctive educational institutions. This implies an obligation upon faculty who have chosen to commit themselves to such an institution to teach in a way that engages positively with its educational project. Policies which provide scope and encouragement for schools and universities to represent distinctive and coherent viewpoints are an essential condition of educational freedom in a pluralistic society. These issues are discussed with reference to the ‘values project‘ of Free University in Amsterdam and to debates, in the Netherlands and the United States, over the distinctive character of schools. This revised version was published online in August 2006 with corrections to the Cover Date.     

体系、社会和国家:理解《美韩自由贸易协定》

2007年6月,美韩双方签署了《美韩自由贸易协定》。美韩之间为什么要签署该协定?该协定对两国国内分别产生了哪些影响?该协定为何至今没能获得美国国会的通过?针对上述问题,本文结合美国贸易政策理论,从体系、国家和社会三个层面对其进行了分析。《美韩自由贸易协定》的签署及其实施,在体系层面上将会为双方带来经济、政治和战略上的多重收益,而在社会层面上却产生了不同的反应。尽管由于国内经济困难和利益集团的掣制使得协定的通过还面临不小的阻力,但基于协定所蕴含的重要价值和两国政府对此认识的高度一致,协定获得通过只是时间上的问题。     

东亚-北美经济失衡与再平衡分析

本文从国别结构和产品结构分析了20世纪90年代以来东亚—北美经济失衡的变化,认为美国贸易逆差不断扩大是其对外产业转移的结果,东亚地区贸易顺差与日俱增是其承接产业转移的结果。其中,东亚内部再次产业转移导致中国顺差迅速膨胀。为了实现东亚—北美经济再平衡,美国需要采取一些措施扩大出口,控制过度的信贷消费,并对美元采取更加负责的政策;东亚地区需要努力实现由外需驱动型向内需驱动型增长方式的转变,加快产业调整与升级,并把产业链向其他地区延伸。     

Public sector creativity as the origin of public sector innovation: A taxonomy and future research agenda

This systematic literature review analyses how public servants apply workplace creativity to come up with ideas for public sector innovations, defining public sector creativity and analyzing its practices, features, trends, and hiatuses in knowledge for which we provide a future research agenda. Creativity is the origin of innovation. Public sector creativity, however, is theoretically undefined and underexamined, resulting in unclarity on what constitutes public sector creativity. We define public sector creativity as “public servants coming up with novel and useful ideas through various practices.” Our findings indicate that public servants apply at least six taxonomically distinctive creative practices, and although they are involved to different extent in generating the initial idea and thus do not always generate ideas autonomously, they are creative in finding alternative ways to come up with ideas. However, our review indicates hiatuses in knowledge on public sector creativity, for which we provide a future research agenda.     

The Moderating Effect of Criminal Thinking on Certainty of Apprehension in Decisions to Engage in Antisocial Behavior: Replication and Extension

This study explored whether the rational (certainty of punishment) and nonrational (criminal thinking) aspects of antisocial decision‐making interact. A convenience sample of 319 undergraduates (106 men, 213 women) completed a measure of criminal thinking and responded to three fictional vignettes (i.e., cheating on a final examination in a class they were in jeopardy of failing, stealing $50 off a table in a dorm room, and selling marijuana for a friend) at three different levels of risk or certainty of apprehension (50%, 10%, and 1%). Results indicated that participants reported that they would be more likely to engage in antisocial behavior when the certainty of getting caught was low and the level of proactive (P) or reactive (R) criminal thinking was high. An interaction between certainty and criminal thinking was also observed in which the gap between lower and higher criminal thinking respondents grew as the probability of getting caught fell.     

浅析韩国的绿色增长战略

绿色增长正在成为世界谋求经济社会可持续发展的重要经济模式,各国都在寻求实现绿色增长的发展战略。1997亚洲金融风暴、2008年以来的世界性经济衰退促使积极探索经济转型新路的韩国加快了战略转型的步伐。韩国政府为此提出并开始实施“低碳绿色增长战略”,制订并发表了“绿色增长国家战略与五年计划”以及相关的法规,详细阐述了韩国推进这一战略计划的长远规划、战略目标、实施计划、政策措施等,并建立了从中央到地方的组织实施机构。韩国积极推动的绿色增长战略充分揭示了其未来经济发展的基本方向,意在谋求实现经济增长方式的转变、构建未来经济长期稳定发展的新增长模式和动力。     

Screening for malingering/exaggeration of psychiatric symptomatology in prison inmates using the PICTS Confusion and Infrequency scales

A sample of 76 federal prison inmates with a history or current complaints of significant psychiatric symptomatology at intake were followed for a period of 4-39 months by a psychologist who rated the inmate as malingering (n=12), substantially exaggerating (n=32), minimally exaggerating (n=23), or honestly reporting (n=9) signs and symptoms of schizophrenia, bipolar disorder, major depression, or severe anxiety disorder. The Confusion-revised (Cf-r) and Infrequency (INF) scales of the Psychological Inventory of Criminal Thinking Styles, which had been administered routinely at intake, revealed that only the INF successfully predicted malingering and exaggeration of psychiatric symptomatology even after pre-existing group differences in age, race, and overall criminal thinking were controlled. These results suggest that the INF scale can potentially serve as an effective initial screening measure for malingering/exaggeration in inmates presenting with mental health complaints.     

Black–white differences in positive outcome expectancies for crime: A study of male federal prison inmates

Purpose

This study was designed to assess whether black inmates hold more positive outcome expectancies for crime than white inmates in an effort to inform the debate on the nature of well documented differences in criminal involvement between blacks and whites.

Methods

Positive outcome expectancies for crime were measured in 393 black male inmates and 154 white male inmates housed in a medium security federal correctional institution using the Outcome Expectancies for Crime (OEC: Walters, 2003b) inventory.

Results

Black inmates reported significantly stronger positive outcome expectancies for crime than white inmates after controlling for preexisting group differences in age, education, marital status, confining offense, response style, general criminal thinking, and negative outcome expectancies for crime. Anticipation of social benefits for crime in the form of love, respect, and security were particularly salient in distinguishing between black and white inmates.

Conclusions

It is speculated that an interaction of motivational (high achievement motivation), structural (blocked economic opportunities), and cultural (peer reinforcement) factors may be responsible for black-white differences in crime with important implications for theory, research, and clinical practice.