Support for emergency department screening for intimate partner violence depends on perceived risk

Emergency department (ED) screening for intimate partner violence (IPV) faces logistic difficulties and has uncertain efficacy. We surveyed 146 ED visitors and 108 ED care providers to compare their support for ED IPV screening in three hypothetical scenarios of varying IPV risk. Visitor support for screening was 5 times higher for the high-risk (86%) than for the low-risk (17%) scenario. Providers showed significantly more support for the need for ED IPV screening than visitors. Controlling for confounding by gender, race, experience with IPV, hospital, and marital status did not affect comparisons between groups. These responses indicate greater support for IPV screening in the ED for high-risk than for low-risk cases, particularly among visitors.     

Detection and quantification of the age-related point mutation A189G in the human mitochondrial DNA

Mutation analysis in the mitochondrial DNA (mtDNA) control region is widely used in population genetic studies as well as in forensic medicine. Among the difficulties linked to the mtDNA analysis, one can find the detection of heteroplasmy, which can be inherited or somatic. Recently, age-related point mutation A189G was described in mtDNA and shown to accumulate with age in muscles. We carried out the detection of this 189 heteroplasmic point mutation using three technologies: automated DNA sequencing, Southern blot hybridization using a digoxigenin-labeled oligonucleotide probe, and peptide nucleic acid (PNA)/real-time PCR combined method on different biological samples. Our results give additional information on the increase in mutation frequency with age in muscle tissue and revealed that the PNA/real-time PCR is a largely more sensitive method than DNA sequencing for heteroplasmy detection. These investigations could be of interest in the detection and interpretation of mtDNA heteroplasmy in anthropological and forensic studies.     

La commission parlernentaire: mécanisrne d'imputabilitéà l‘égard des sous-ministres et des dirigeants d'organismes

Sommaire: Plusieurs parlementaires, divers analystes et deux commissions d'étude récentes, l'une au palier fédéral (Lambert) et l'autre au Québec (Bisaillon), ont traité de la possibilité d'implanter un régime d'imputabilité pour les administrateurs publics, particulièrement les sous-ministres et les dirigeants d'organismes. Les modifications apportées, au début de la présente année, aux règles de procédure de l'Assemblée nationale vont permettre une certaine expérimentation à cet égard. Une telle réforme améne l'auteur à examiner diverses contraintes qui pourraient influencer et même jouer contre son implantation, notamment: les principes de la responsabilité et de la solidarité ministérielles, l'évolution des rapports entre le gouvernement et l'administration, les différences de statut entre les sous-ministres et les dirigeants d'organismes et les précédents relatifs à la participation des sous-ministres et des dirigeants d'organismes aux travails de l'Assemblée. Ces contraintes sont assurément sérieuses car elles remettent en cause des éléments majeurs du système politique. Reste à savoir si, comme cela se produit souvent, les hommes politiques réussiront encore une fois à concilier ce qui paraît incompatible. Abstract: Several members of Parliament, various analysts and two recent commissions of inquiry, one federal (Lambert Commission) and the other from Quebec (Bisaillon), have studied the possibility of implementing an accountability system for public administrators, particularly deputy ministers and chief executive officers of agencies. Amendments brought forth earlier this year to the procedures of the National Assembly of Quebec will allow for experimentation in that area. Such a reform leads the author to examine various constraints in its implementation; in particular, the principles of ministerial responsibility and soolidarity; the evolution of relationships between government and administration; the status differences between deputy ministers and chief executive officers of agencies; the precedents concerning the participation of deputy ministers and chief executive officers in the work of the Assembly. Those constraints are of great importance since they challenge some major elements of the political system. It remains to be seen whether politicians will succeed once again in reconciling what appears to be incompatible.     

Allele frequencies and haplotypes of 8 Y-chromosomal STRs in the Santa Catarina population of southern Brazil

Allele frequencies and haplotypes of eight Y-chromosomal short tandem repeats (STRs), DYS19, DYS385, DYS389 I, DYS389 II, DYS390, DYS391, DYS392 and DYS393 were determined in a sample of 109 males from Santa Catarina. The origin of this southern Brazilian population is mainly from Portuguese people, namely from Azores archipelago.     

Analysis of gamma-hydroxybutyric acid (GHB) in spiked water and beverage samples using solid phase microextraction (SPME) on fiber derivatization/gas chromatography-mass spectrometry (GC/MS)

Gamma-Hydroxybutyric acid (GHB) is a CNS depressant that has been abused recreationally for its purported euphoric and relaxation effects and for the purposes of drug facilitated sexual assault due to its sedative and amnesic effects at higher doses. The dramatic increase in the abuse of GHB and association in criminal investigations over the past decade has created the need for forensic laboratories to develop analytical methods to detect GHB in a variety of matrices. The method developed in this work used solid-phase microextraction (SPME) to extract GHB from aqueous samples followed by on-fiber derivatization and analysis by gas chromatography/mass spectrometry (GC/MS). This method detected GHB in aqueous matrices with good sensitivity, high precision, excellent linearity from 0.01 mg/mL to 0.25 mg/mL, and without the need for sample manipulation that could cause interconversion between GHB and its lactone, GBL. The method was successfully applied for detection of GHB in spiked water and beverage samples.