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Oxycodone is a potent semi-synthetic narcotic prescribed for the management of pain. Previous investigators have reported that the abuse of oxycodone is most frequently seen in conjunction with the abuse of other drugs, although fatalities have been reported with oxycodone alone. We undertook a retrospective review of cases investigated by the Palm Beach County Medical Examiner's Office in which postmortem toxicologic studies indicated the presence of oxycodone. A total of 172 consecutive cases were studied, including 18 in which death was attributed to oxycodone toxicity, 117 to combined drug toxicity, 23 to trauma, 9 to natural causes and 5 to another drug or drugs. The postmortem blood concentrations of oxycodone overlapped among the groups. The mean blood oxycodone concentration among the cases of oxycodone toxicity was 0.69 mg/L, combined drug toxicity 0.72 mg/L and trauma 0.62 mg/L. Concentrations were lower in cases of deaths attributed to natural causes and to another drug or drugs (mean each 0.087 mg/L). Benzodiazepines, detected in 96 cases, were the most common co-intoxicants in the cases of combined drug toxicity, followed by cocaine, which was found in 41. The most frequently encountered benzodiazepine was alprazolam. This study confirms that deaths in which oxycodone is a factor are most commonly cases of combined drug toxicity. The high incidence of alprazolam as a co-intoxicant has not been previously recognized.  相似文献   
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Despite recent declines in overall sexual activity, sexual risk-taking remains a substantial danger to US youth. Existing research points to athletic participation as a promising venue for reducing these risks. Linear regressions and multiple analyses of covariance were performed on a longitudinal sample of nearly 600 Western New York adolescents in order to examine gender- and race-specific relationships between jock identity and adolescent sexual risk-taking, including age of sexual onset, past-year and lifetime frequency of sexual intercourse, and number of sexual partners. After controlling for age, race, socioeconomic status, and family cohesion, male jocks reported more frequent dating than nonjocks but female jocks did not. For both genders, athletic activity was associated with lower levels of sexual risk-taking; however, jock identity was associated with higher levels of sexual risk-taking, particularly among African American adolescents. Future research should distinguish between subjective and objective dimensions of athletic involvement as factors in adolescent sexual risk.Research Scientist at the Research Institute on Addictions of the University at Buffalo. Received PhD in sociology from the University at Buffalo. Research interests include adolescent athletic involvement, gender, race, and health-risk behavior, particularly substance use.Department Chair and Professor of Sociology at the University at Buffalo. Received PhD in sociology from Yale University. Research interests include the effects of families, friendships, and organizational participation on adolescent development and substance use.Senior Research Scientist at the Research Institute on Addictions of the University at Buffalo. Received PhD in sociology from the University at Buffalo. Research interests include family influences on adolescent substance use, gambling, and other problem behaviors.Professor of Physical Education and Sport at SUNY College at Brockport. Received PhD in physical education from Ohio State University. Research interests include the sociology of sport, social psychology of sport, sport group dynamics, and sport spectatorship/fandom.Professor of Sociology at DYouville College. Received PhD in sociology from the University at Buffalo. Research interests include the sociology of sport, gender, and mens health.  相似文献   
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This paper presents the case of First 5 LA's 5-year countywide implementation of the Parent–Child Interaction Therapy (PCIT) program. Enthusiasts of PCIT point to it as a high-quality parenting program with the potential to positively influence child behavior, reduce recidivism into the child welfare system, and increase caregiver's confidence and self-esteem. In September 2012, First 5 LA, an independent County agency in Los Angeles that advocates on behalf of parents with young children, began a $20 million countywide implementation of PCIT. The collaborative effort between First 5 LA, the Los Angeles County Department of Mental Health, the Los Angeles County Department of Children and Family Services, and the University of California, Davis demonstrates the role that research and data analysis can play in improving large-scale implementations. The authors of this paper were contracted to conduct an evaluation of the implementation of the countywide PCIT program, and preliminary outcomes were analyzed after the first round of data collection in early 2015. This paper will discuss this case and provide examples of how research and data analysis were used effectively to make key improvements to the design and implementation of the program. The paper will then discuss bureaucratic challenges and constraints with the collaborative use of research and data. The paper will conclude with some recommendations on how research and data can effectively be used to influence policy implementation in large-scale implementations involving collaboration among multiple organizations.  相似文献   
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A Filipino farmer keeps his own record of his experience with the new high‐yielding rice varieties and their accompanying technology over a period of eight years. Since in some seasons he accepts the government's technology and credit package, and in other seasons he manages the farm independently, the record enables comparison of management strategies and results. It suggests how erratic and expensive the new technology is, and indicates that both costs and risks increase under the state's finance and supervision. The liabilities and implications of agricultural research and assistance ‘packages’ are discussed.  相似文献   
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