Metabolism and toxicological detection of the designer drug N-(1-phenylcyclohexyl)-3-methoxypropanamine (PCMPA) in rat urine using gas chromatography-mass spectrometry

Studies on the metabolism and the toxicological detection of the phencyclidine-derived designer drug N-(1-phenylcyclohexyl)-3-methoxypropanamine (PCMPA) in rat urine are described using gas chromatographic-mass spectrometric (GC-MS) techniques. Based on the identified metabolites, the following metabolic pathways could be postulated: N-dealkylation, O-demethylation partially followed by oxidation of the resulting alcohol to the corresponding carboxylic acid, hydroxylation of the cyclohexyl ring at different positions, and aromatic hydroxylation. The formed metabolites were identical to those of the homologue N-(1-phenylcyclohexyl)-3-ethoxypropanamine (PCEPA) with exception of the mono hydroxyl metabolites of PCEPA. All PCMPA metabolites were partially excreted in conjugated form. An intake of a common drug users' dose of PCMPA could be detected in rat urine by the authors' systematic toxicological analysis (STA) procedure using full-scan GC-MS after acid hydrolysis, liquid-liquid extraction and microwave-assisted acetylation. The STA should be suitable for proof of an intake of PCMPA also in human urine assuming similar metabolism.     

Translation Approaches in Constitutional Hermeneutics

International Journal for the Semiotics of Law - Revue internationale de Sémiotique juridique - In this article, we suggest an alternate approach to interpreting the US Constitution, using...     

Longitudinal Linkages between Older and Younger Sibling Depressive Symptoms and Perceived Sibling Relationship Quality

The sibling relationship has an important impact on children’s emotional functioning, but it is yet unclear whether and how sibling relationship quality affects adolescent depressive symptoms over time. This study contributes to existing knowledge by examining the relative importance of three aspects of sibling relationship quality (i.e., support, conflict and power balance) on the one hand and sibling depressive symptoms on the other hand in predicting adolescent depressive symptoms over time. Additionally, this study examined whether these influence patterns were moderated by perceived sibling relationship quality and by dyadic gender composition. Across six annual waves, 412 Dutch adolescents (57% boys; M_age?=?12.34 years) and their older siblings (47% boys; M_age?=?15.36 years) reported on depressive symptoms and sibling relationship quality. Cross-lagged panel analyses showed that only sibling depressive symptoms and not perceived relationship quality predicted adolescent depressive symptoms one year later. This effect was not moderated by sibling relationship quality or gender composition. These results indicate that sibling depressive symptoms may be a risk factor for adolescent depressive symptoms.

     

Oxytocin Receptor Gene (OXTR) and Deviant Peer Affiliation: A Gene–Environment Interaction in Adolescent Antisocial Behavior

Although the oxytocin receptor gene (OXTR) is involved in aggression and social affiliation, it has not been examined in gene-environment interaction studies. This longitudinal study examined the effect of genetic variants in OXTR and its gene-environment interaction with perceived deviant peer affiliation in the trajectories of antisocial behavior in 323 adolescents (182 males) from 13 to 18 years. Annual assessments of reactive and proactive aggression, delinquency, and friends’ delinquency, as well as DNA at age 17 were collected. Gene-based tests yielded no main effect of OXTR, but revealed a significant gene-environment interaction in proactive aggression and delinquency. Variation in the OXTR might affect the influence of deviant peer affiliation on antisocial behavior, contributing to a better understanding of individual differences in antisocial behavior.

     

Does Disclosure of Performance Information Influence Street‐level Bureaucrats’ Enforcement Style?

Governments use different regulatory instruments to ensure that businesses owners or “inspectees” comply with rules and regulations. One tool that is increasingly applied is disclosing inspectees’ performance information to other stakeholders. Disclosing performance information has consequences for street‐level bureaucrats because it increases the visibility of their day‐to‐day work. Using a survey (n = 507) among Dutch inspectors of the Netherlands Food and Consumer Product Safety Authority, this article shows that the disclosure of performance information has an impact on enforcement style at the street level. Findings show that perceived disclosed performance information positively enhances all three dimensions of street‐level bureaucrats’ enforcement style (legal, facilitation, and accommodation). This effect is strongest for facilitation and accommodation and weakest for the legal style. Perceived resistance by inspectees partly explains this effect. Contrary to expectations, more perceived disclosure does not result in more but in less perceived resistance of inspectees by street‐level bureaucrats.     

Development of the PIP Organizational Models: Examples from the Armenian Transport Sector

The present article analyzes a general approach of the development of public infrastructure provision (hereinafter PIP) organizational models focusing on the structure of the privatization, partnership, business, contractual, and financial models of Armenia. The adopted approach of using the general map of the PIP toolbox gives an opportunity to clearly understand various models of PIP in different countries, compare them on the basis of certain components and to make a ground for the development of the most efficient PIP organizational models in relevant countries. The article introduces a well-defined tool to find the differences within various projects.     

Rising Tides of Ideological Simplifications: A Comparative and Longitudinal Analysis of Local Parties

This article explores the strength and causal determinants of ideological thinking within Swiss local political parties. The concept of “ideologization” refers to (1): “horizontal couplings”, as they are manifested in intercorrelations between different opinions, and to (2) “vertical couplings” of specific opinions to abstract concepts of “left” and “right”. Results show high ideologization on the left‐center section of the LR‐scale, especially in the vertical dimension. On both sides of the spectrum, ideological constraints are significantly higher in larger communities than in than in smaller ones. Only in rather small communities, does ideologization correlate positively with the educational level, the modern occupational background of party members and the number of other local parties with which they have to compete. In communities of given size, ideological thinking is more pronounced when parties possess a small share of political power. Finally, it is found that ideological constraints have increased somewhat between 1989 and 2002.     

The Question of Feminism in Gender Mainstreaming—A Case of Non-conflict in Local Politics

This article discusses gender equality and how and why a gender mainstreaming strategy avoids the question of gender conflict. The making of gender-equality work is studied by investigating how feminism is talked about and rejected in a specific gender mainstreaming project in the municipality of Örebro, Sweden. Drawing upon the theoretical concepts of hegemony and discourse, the focus is on the silences—the unspoken questions and problems—surrounding the project. I examine how the exclusion of feminism and conflict is articulated when gender mainstreaming is introduced as a new way of doing gender-equality work in the municipality. The struggles identified show that feminism is rejected because it is seen as being in opposition to (1) professionalism and (2) legitimate political issues. I conclude that within the local discourse of gender mainstreaming there is a notion that this form of gender-equality work ought to be performed without harmful or threatening gender conflicts. This means that the strategy of gender mainstreaming constitutes a short-cut to bypass controversial problems like equal treatment, special efforts for women, and men's privileges in gender-equality work.     

Off the Hook: Measuring the Impact of Mobile Telephone Use on Economic Development of Households in Uganda using Copulas

It is now widely understood that mobile phone use has beneficial effects on development in developing countries, but little is known about the effects at the household level. We examine the impact of mobile telephone use on household income using a unique cross-sectional data set from Uganda. We use a novel econometric technique to handle endogeneity, which models the correlation between the endogenous regressor and the error term with copulas. To the best of our knowledge, this is the first time that the copula method has been applied in the economic development literature. We find a positive impact of mobile phone use on income.     

The Politics of Perception: Use and Abuse of Transparency International's Approach to Measuring Corruption

The annual Corruption Perceptions Index (CPI), published by Transparency International (TI), has had a pivotal role in focusing attention on corruption. Despite recent critiques of the CPI, it remains highly influential on research into the causes of corruption and is also extensively used to galvanise support for measures to fight corruption. In this article we explore the CPI in more depth in order to highlight how the index has been used for political ends which may not always turn out to be supportive of anti-corruption efforts. The argument is developed in four sections: in the first, we focus on Transparency International's definition of corruption, highlighting some conceptual difficulties with the approach adopted and its relationship to the promotion of 'good governance' as the principal means of combating corruption. In the second section, we outline some methodological difficulties in the design of the Corruption Perceptions Index. Although the CPI has been much criticised, we demonstrate in the third section that the index continues to exercise great influence both in academic research and in the politics of anti-corruption efforts, particularly as exercised by Transparency International itself. In the final section we argue that the CPI contributes to the risk of creating a 'corruption trap' in countries where corruption is deeply embedded, as development aid is increasingly made conditional on the implementation of reforms which are impossible to achieve without that aid.