Validation of Ultrastructural Analysis of Mitochondrial Deposits in Cardiomyocytes as a Method of Detecting Early Acute Myocardial Infarction in Humans*

Abstract: In the present study, ultrastructural analysis of mitochondrial deposits (black dots within mitochondria) as a method for the detection of early acute myocardial infarction (AMI) was evaluated. In 24 patients with AMI and six controls, analysis was performed in the heart of infarcted patients and noninfarcted controls. In the infarction area in lactate dehydrogenase (LDH)‐diagnosed AMI, the percentage of positive mitochondria was significantly higher compared to corresponding heart tissue in control patients and compared to noninfarcted areas within these patients. Also in patients with a clinically diagnosed AMI but no LDH decoloration, a significant higher percentage of positive mitochondria was found in the left ventricle compared to controls and noninfarcted areas. In patients with AMI, an increase in mitochondria with deposits was found in the infarction area compared to controls and noninfarcted tissue within the same patient, suggesting that electron microscopical changes in mitochondria can be used for the diagnosis of AMI less than 3 h old.     

Reliability and validity of cross-national homicide data: a comparison of UN and WHO data

Data reliability and validity are methodological concerns in cross-national analyses of crime, but there is little agreement on which source of data provides the most reliable estimates. Moreover, few studies have examined the potential threat to validity posed by unclassified deaths. The current study aims to (1) assess the reliability of cross-national homicide data from the United Nations (UN) and the World Health Organization (WHO); and (2) investigate the impact of unclassified deaths on the validity of WHO data. Findings indicate that UN and WHO homicide rates (n=56) differ in magnitude, but produce similar outcomes. The UN data produce more robust results and statistical models with less error. The WHO data are more stable and reliable over time, and better suited for longitudinal analyses. Analyses drawing on WHO data should not disregard unclassified deaths because their inclusion provides a more accurate estimate of the true number of homicides.     

Panel on the Economic and Political Consequences of Chernobyl'

This article summarizes a discussion by a panel of leading experts on Soviet energy analyzing the consequences of the accident at the Chernobyl' nuclear plant in the Ukraine on April 26, 1986.

The near-term economic costs associated with clean-up, relocation, and compensating for losses to electricity supplies are significant but manageable. The longer-term effects will focus on likely modifications in Soviet strategies for the nuclear industry, which may shift emphasis back towards conventional fuels and conservation.

The political consequences were managed fairly well by the leadership. Consistent with Secretary Gorbachev's policy of glasnost' (openness) more information has been available on this event than was the case in previous analogous situations. Journal of Economic Literature, Classification Numbers: 027, 124, 723.     

Definitions and Typologies in Public Administration Research: The Case of Decentralization

The field of public administration knows many concepts. By focusing on one such concept, this research shows how definitions can be deceptive, and how typologies unable to capture all dimensions of a concept can blind policy makers and researchers. We concentrate our attention on decentralization. This has been a core concept in the field of public administration for decades. Definitions and typologies of decentralization have flourished. The present study gives an overview. We categorize definitions and analyse their different emphases. Typologies serve to order and compare items, but have themselves become prone to disorder. We provide a meta-analysis of typologies, exposing the wide variety of policy dimensions. Even after aggregation, typologies ignore—and definitions explicitly exclude—certain aspects of decentralization. One such issue is “silent decentralization.” It is characterized by absence of explicit decentralization reform, and thus distinguishes itself mainly by its potential origins: network changes, initiative shifts, policy emphasis developments, or resource availability alterations. Highlighting this particular aspect might well proof useful for other concepts in the field as well.     

Effects of Delinquency on Alcohol use Among Juveniles in Europe: Results from the ISRD-2 Study

The existence of a correlation between the use of alcohol and juvenile delinquency has long been acknowledged. In order to evaluate the strength and the characteristics of this association in various cultural contexts, we analysed data collected as part of the International Self-Report Delinquency Study- 2 (ISRD-2). The sample consisted of of young people (N?=?57,771) of both sexes, aged between 12 and 16 years, in 25 European countries. After estimating the prevalence of alcohol consumption among young people involved in property offences and violent offences, we assessed the degree to which these types of delinquency were associated with the use of alcohol in the 25 countries. In addition, we attempted to ascertain the influence of belonging to various types of deviant groups on alcohol use. To this end, we used a Mokken Scale Analysis. With this method, we constructed a scale of “gangness” and correlated the scores with alcohol use among juveniles. The results yielded by the present study indicate that alcohol use and delinquency are closely related with one another. In particular, we observed that alcohol consumption seems to be strongly influenced by involvement in delinquent activities. The nature and characteristics of these relationships suggest that the associations between alcohol use and delinquency are reciprocal rather than one-directional. Consequently, alcohol use constitutes a risk factor for criminal behaviour. Likewise, involvement in delinquency increase the risk of alcohol consumption and, especially, of alcohol abuse.     

Physical stature and biological living standards of girls and young women in the Netherlands,born between 1815 and 1865

This is the first study in Dutch anthropometric historiography that describes and analyzes the development of the biological standard of living of girls and young women from the perspective of female adult stature. It is shown that adult stature of women, imprisoned in the second half of the nineteenth century and born between 1815 and 1865, slightly increased, approximately 1cm. From 1850 onwards stature of women born in the cities notably increased. Development of female adult stature was compared to that of male stature; both were quite similar. No circumstantial evidence was found that girls or young women were on a disadvantage with respect to nutrition and (medical) care.     

Sibling incest: A literature review and a clinical study

Abstract

Few previous studies have explored the characteristics and dynamics of adolescent sibling incest. The objectives of this paper were twofold: first, to conduct a literature review that accounts for earlier research in the area, and secondly, to conduct a clinical study to explore differences regarding the characteristics of a group of adolescent sibling incest offenders (n=21) compared to a group of adolescent non-sibling offenders (n=24). Comparisons were made regarding variables such as family dysfunction, the offenders' prior victimization and offending behaviour. The data were derived from intake assessment files and semi-structured interviews with 45 adolescents who had sexually offended. The sibling incest offender group had grown up more often in dysfunctional families. Moreover, the results indicated that the offending behaviour in the sibling incest group was more severe. The study gives some empirical support for the possibility that sibling incest can be one sign, among others, of maltreatment during childhood.     

To have a voice in the matter: A comparative study of the Swedish and Danish European committees

This article deals with the issue of how the national parliaments might be strengthened in order to decrease the democratic deficit within the EU. It examines the parliamentary European committees in the Danish and Swedish Parliaments and concludes that their potential to influence and control their respective governments’ EU policies mainly depends on the Government's parliamentary base and opportunities for legislative influence open to parliamentary oppositions. Moreover, it examines various organisational aspects of the European committees, including distribution of tasks and internal co‐ordination within the Parliament, at what stage in the decision‐making process the European Committee and the Parliament are involved and information management. With some conspicuous exceptions, Denmark and Sweden have chosen the same organisational arrangements for dealing with EU affairs both in the Parliament as a whole and, specifically, in the European committees. The principal conclusion is that the European committees in Sweden and Denmark are effective means for giving the national parliaments a voice in EU matters, but the article also addresses some reforms to strengthen their positions.