Simultaneous analysis of d-3-methoxy-17-methylmorphinan and l-3-methoxy-17-methylmorphinan by high pressure liquid chromatography equipped with PDA

d-3-Methoxy-17-methylmorphinan (Dextromethorphan, DXM), which is a structural analog of morphine and codeine, has been widely used as a non-narcotic antitussive agent. It is a safe drug in therapeutic dose and does not produce analgesic effects, while its enantiomer, l-3-methoxy-17-methylmorphinan called levomethorphan (LXM) is a potent narcotic analgesic. DXM has been widely abused in Korea due to its hallucinogenic effect in large doses; therefore, the health authorities have regulated its use as a psychotropic agent since 2003. As its abuse has been serious, a possibility that DXM would be smuggled into Korea has also increased. Moreover, it has been suspected that there was the possibility of the adulteration or substitution of DXM with LXM due to their chemical similarities. Therefore, it was necessary for us to establish the enantiomeric separation of DXM and LXM. In this study, a liquid chromatographic method using a chiral column capable of separating stereoisomers of DXM as well as analyzing the major metabolites of DXM, 3-methoxymorphinan, 3-hydroxymorphinan, and 17-hydroxymethylmorphinan was developed. The validation of a method was studied through repeatability of retention times. Using this method, 32 confiscated DXM samples were analyzed to identify the enantiomers of DXM. As a result, DXM was detected in all samples and there was no evidence of the adulteration or substitution of DXM with LXM. Nevertheless, the stereochemical analysis of DXM and LXM is important not only to identify starting materials for illegal drug manufacture but also to understand the trends of abused drugs.     

Homicide-suicide in Hong Kong, 1989-1998

This study provides the first systematic research of homicide-suicide (HS) in a Chinese society. Data were drawn from the HK Homicide Monitoring Data-base computer file derived from investigation and death reports held by the HK Police Force and the Coroner's Court. During the 10-year study period, 56 events involving 133 deaths were identified. The majority of offenders were males (75%) and most victims were female (64%). The mean age of offenders and victims were 41.9 and 32.3 years, respectively. Spouses and lovers comprised the majority of victims (46.4%) followed by child victims (36%). Most HS events were motivated by separation or termination of marital or sexual relations (39%), economic reasons (25%) and other domestic disputes (20%). The most frequent modes of killing were strangulation/suffocation (26%), stabbing/chopping (24%), followed by gassing/poisoning (14%) and falling from height (14%). The commonest of suicide was falling from height (48%). It was followed by gassing/poisoning (22%) and strangulation/suffocation (13%). Depression (18.3%) was found to be the commonest mental disorder. Most offenders were from low-socio-economic background. Two-third were unemployed and 76.6% had 9 or less years of education. HS in HK were distinguished from those reported in the western literature in respect to the high relevance of economic factors, the absence of mercy killing between old couples, a higher percentage of pedicide-suicides and the infrequent use of firearms.     

‘Three Chinas’ and international organizations after 1997

This article analyzes the effects of the transfer of Hong Kong's sovereignty to China in 1997 on the participation of Hong Kong and Taiwan in international organizations. It identifies the conditions under which China tolerates co‐existence with Taiwan as members of eleven intergovernmental organizations as of 1996. It concludes with two observations: one, international organizations are not monolithic entities; two, although China has overwhelming influence over Hong Kong's participation in these organizations, it depends also on how the Hong Kong Special Administrative Region government is going to manage its relations with China.     

Depressive symptoms and coping strategies among Chinese adolescents in Hong Kong

Depressive symptoms and coping strategies of 161 Chinese adolescents were assessed and described using the Beck Depression Inventory (BDI) and the Ways of Coping Questionnaire (WCQ). Using the BDI cutoff scores of 9/10 and 29/30, respectively, over 64% of the adolescents would be in the depressed range, and 9% would be in the severely depressed range. For general depressive symptom level, Chinese adolescents appeared to have higher mean BDI score than U.S. adolescents and Chinese young adults. Their depressive symptom levels were found to relate to avoidant coping strategies as well as low self-es-teem and reduced social support. Implications for promoting adaptive coping, peer support network, and self-esteem enhancement were discussed.This study was supported in part by a Chinese University of Hong Kong UPGC direct grant for research.Received Ph.D. from the University of Western Ontario in 1978. Research interests include self-esteem, stress, coping, health, and psychopathology.     

行政垄断问题研究在中国

本文细致地分析了行政垄断问题研究在中国的发展进程,指出了从20世纪80年代初到现在,行政垄断问题研究在中国经历的几个阶段以及每个阶段形成的原因,并从两个层次具体分析了中国学者在行政垄断问题研究上的共识和分歧。     

Who benefits from minority business set-asides? The case of New Jersey

Race-based remedies often are justified by evidence of prior discrimination. They work when they benefit groups previously disadvantaged. This article examines one such remedy—minority business set-asides—and its application in the award of public procurement and construction contracts by the state of New Jersey. Analyzed are contract awards to minority and non-minority/non-women-owned business enterprises in 1990, as well as in periods before, during, and after the imposition of a state minority set-aside program. Using a conventional decomposition approach, the article reveals significant discriminatory gaps in the success of minority- versus non-minority-owned firms in obtaining contracts from the state of New Jersey. The analysis suggests that minority contracting success rates fell from the pre-set-aside era to the set-aside era and that discriminatory outcomes persisted. The particular remedy chosen—while justified based on evidence of prior discrimination—appears not to have reduced the original discrimination nor did it unambiguously benefit minority businesses.     

Bureaucratic control and information processing: An institutional comparison

Standard models of bureaucratic control argue that politicians vulnerable to asymmetric information rely on third‐party monitoring to expand information supply. This solution to information asymmetry assumes that politicians can process all information that comes their way. However, advocates strategically oversupply information to crowd out rivals, making such a solution counterproductive. Using data on administrative reorganization in Hong Kong, we examine the alternative proposition that bureaucratic control is contingent not only on how information is obtained but also on how it is processed under two different institutional arrangements: one that splits attention across domain‐specific streams and one that concentrates attention in a single sequence. In both cases, bureaucrats refrain from major changes when politicians break from these arrangements. Moreover, bureaucratic action is significantly more likely to respond to changes in attention allocation when politicians process information in multiple streams.     

Examining Relationships Between Legislative and Presidential Influences and Organizational Probity: Evidence from South Korean Central Government Agencies

In public management, few empirical studies have been conducted on the effects of the most influential political authorities—the legislature and the president—on government organizations, despite the theoretical and practical significance of these effects. This study tests the relationships between legislative and presidential influences and organizational probity in South Korean central government agencies, on the basis of political transaction-cost and principal–agent theories. We use three measures of legislative influence—inspectional influence (total annual days of legislative inspection), statutory influence (rules-to-laws ratio), and budgetary influence (ratio of reprogramming budget to total budget), and one measure of presidential influence (annual number of substantive meetings with the president). Then, these independent variables are linked to the organizational probity measure from audited archival data. The two-time-point panel data analysis reveals a positive link between legislative inspectional influence and probity but a negative relationship between the presidential influence measure and probity; the results support theoretical arguments for control over administrative agencies. Thus, the evidence suggests that governments should be cautious of implementing reforms that increase organizational or managerial autonomy.