Minors and informed consent: a comparative approach

The European Convention on Human Rights and Biomedicine of the Council of Europe provides in article 6 for special protection of persons who are not able to give free and informed consent to an intervention in the health field, e.g. minors. According to the second paragraph of this article it is up to domestic law to decide whether and under which conditions a minor is capable of taking autonomous decisions in the health field. In the present article an overview is given of the legal regulations in place regarding the position of minors in a health care setting in the EU Member States that have ratified the European Convention on Human Rights and Biomedicine namely Cyprus, Czech Republic, Denmark, Estonia, Greece, Hungary, Lithuania, Portugal, Slovakia, Slovenia and Spain. As the overview will show, the legal position of minor patients in a health care setting varies from country to country. This in view of the system they have opted for as well as the age and circumstances under which minors are allowed to take health care decisions autonomously.     

Measurement and analysis of diastereomer ratios for forensic characterization of brodifacoum

The highly toxic anticoagulant rodenticide brodifacoum is an organic compound that has two diastereomeric forms. In this paper, we consider the hypothesis that the relative population of the diastereomers is a characteristic of forensic value for the association or source attribution of specimens of brodifacoum. In general, the stereoisomer distribution in an organic compound depends on the reagents, conditions, and methods used for synthesis and purification, and may vary over time due to differential stabilities of the stereoisomers. The stereoisomer distribution may thus serve as an identifier of the production methods and history of samples and provide a basis for comparing recovered specimens. We refer to this novel approach for signature detection as stereoisomer distribution analysis or SDA. If the stereoisomers are diastereomers, quantitative determination of the diastereomer ratio in a specimen can be performed by a number of techniques, notably gas or liquid chromatography or nuclear magnetic resonance (NMR) spectroscopy. This paper describes an NMR spectroscopic analysis of ten commercial technical grade brodifacoum samples from distinct batches originating from three different sources. The results reveal detectable source-to-source and batch-to-batch variations in diastereomer ratios.     

When the study of delinquent groups stood still: In defense of a classical tradition

This essay focuses on reductionism, the study of delinquent groups, and citation analysis. It describes Frederick Thrasher’s epistemological break with reductionists like Sigmund Freud and William Healy. It shows how Freudian, neoFreudian, and social-control theorists attributed ‘the group factor’ in delinquency to pathological traits, early childhood disorders, frustrated desires for mobility, or social disabilities of group members. From 1950 to 1970, the mobilization of bias accompanying these regressive developments nullified a classical sociological view of delinquent groups by transforming a fruitful legacy of non-reductionist theory and research into ‘non events’. When criminologists employ citation indices to legitimate such degenerative developments, they rely on spurious subjective criteria for gauging scientific contributions to knowledge.     

Physiological Relaxation: Stress Reduction Through Fair Treatment

The effects of fair treatment on physiological stress reactions of participants in a moderately high or low mental pressure condition are studied. On the basis of Injustice Stress Theory IST; Vermunt, R., and Steensma, H. In: Cropanzano, R. (ed.), Justice in the Workplace (Vol. 2), Erlbaum, Hillsdale, NJ, pp. 27–48,2001, predictions were made about procedural fairness as stress reducing factor. The results supported the expected effect of fair treatment, in that lower cardiovascular activity was measured after fair treatment but not after unfair treatment. Moreover, three-way interactions showed that participants with type-A behavior in the low mental pressure conditions had lower cardiovascular activity after fair treatment but not after unfair treatment, while participants with type-B behavior showed lower cardiovascular activity after fair treatment in the moderately high mental pressure condition. The discussion focuses on the difference between fair treatment and social support as well as on the several ways to reduce stress by being fair.     

A single-column procedure on Bond Elut Certify for systematic toxicological analysis of drugs in plasma and urine.

A single-column solid-phase extraction procedure was developed for the screening of acidic, neutral, and basic drugs from plasma. The recoveries of all 25 tested drugs exceeded 82%. After the plasma had been diluted with phosphate buffer (pH 6.0), the drugs were extracted using a single Bond Elut Certify column. The acidic and most of the neutral drugs were eluted by acetone/chloroform (1:1) and the basic drugs were eluted by 2% ammoniated ethyl acetate. Some neutral drugs appeared in both fractions. The two fractions were collected separately and evaporated until approximately 100 microL of solvent remained in the tube. Both fractions were analyzed separately on a gas chromatograph equipped with a wide-bore capillary column and a flame ionization detector. The procedure could also be used for urine samples.     

Multicenter evaluation of ultrafiltration, dialysis, and thermal coagulation as sample pretreatment methods for the colorimetric determination of paraquat in blood and tissues

Three methods of sample pretreatment for the rapid colorimetric determination of paraquat were compared: ultrafiltration, dialysis, and thermal coagulation. Spiked autopsy blood and tissue samples were examined in parallel in Groningen and Krakow and some samples were interchanged. All three methods gave recoveries between 87 to 102%; accuracy at the 20-mg/L level was within 10% of the target value and coefficients of variation in the 10 to 60-mg/L range were between 3 to 15%. Determinations in blood and liver in a fatal case of Gramoxone poisoning showed excellent agreement. Because of its reliability, speed, and simplicity, ultrafiltration is the method of choice.