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Hair analysis has shown great potential in the detection and control of drug use. Whether an assay is of quantitative value roughly corresponding to the amount of drug consumed, is still a matter of debate. The present investigation was aimed at a possible relationship between the cannabinoid concentration in hair and the cumulative dose in regular users of cannabis. Hair samples from the vertex region of the scalp were obtained from 12 male regular users of cannabis, and 10 male subjects with no experience of cannabis served as controls. None of the subjects had his hair permed, bleached or colored. Cannabis users provided information on drug use such as the current cannabis dose per day, the cumulative cannabis dose of the last 3 months, as well as the frequency of cannabis use during the last year. The concentration of delta-9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) in hair was determined using gas chromatography-mass spectrometry. Cannabinoids were present in any hair sample of cannabis users, but were not detectable in control specimens. An increase in the amount of cannabinoids in hair with increasing dose was evident. The concentration of major cannabinoids (sum of THC, CBD and CBN) was significantly correlated to either the reported cumulative cannabis dose during the last 3 months or to the cannabis use during the last 3 months estimated from the daily dose and the frequency per year (r=0.68 or 0.71, p=0.023 or 0.014). A significant relationship between THC and the amount of cannabis used could not be established. As a conclusion, the sum of major cannabinoids in hair of regular users may provide a better measure of drug use than THC. 相似文献
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Ott Hermann E. 《International Environmental Agreements: Politics, Law and Economics》2001,1(4):469-476
This article provides a short account of the international climate negotiations that took place in Bonn from 16 to 27 July 2001. After the Sixth Conference of the Parties to the Framework Convention on Climate Change failed in November 2000, the Parties had decided to suspend the meeting. The ministers present at the resumed session successfully adopted the "Bonn Agreement to the Kyoto Protocol", a set of political compromises for the most contentious issues left open by the Kyoto Protocol. Although many details had been transferred to the Seventh Conference of the Parties, November 2001 in Marrakesh, Morocco, the Bonn Agreement already paved the way for ratification of the Kyoto Protocol and its entry into force. The Marrakesh Accord adopted on 10 November 2001transforms, with a few exceptions, this political agreement into bindinglegal text. 相似文献
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van der Kolk Henk Schmitt Hermann Scholz Evi Thomassen Jacques 《European Journal of Political Research》1997,32(2):283-289
European Journal of Political Research - 相似文献
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The systematic relation between delinquency and the overall spectrum of individual values has not been a particular topic of psychological research in the past. To fill this gap, we refer to Schwartz’s [(1992). Universals in the content and structure of values: Theoretical advances and empirical tests in 20 countries. Advances in Experimental Social Psychology, 25, 1–65] theory of universals in the content and structure of values (TUV) and re-interpret the results of Hermann’s [(2003). Werte und Kriminalität. Wiesbaden: Springer] criminological research on individual reflexive values, norm acceptance, and self-reported delinquency against this background: We verify to what extent the Individual Reflexive Value Scale (IRVS) covers the overall spectrum of values defined by TUV. We validate this match by content analysis and multidimensional scaling (MDS) and compute IRVS-based basic and higher-order value scores. Confirmatory and spherical MDS with these scores yield the circular value structure postulated by TUV. Structural equation modelling (SEM) reveals systematic relations between basic values, norm acceptance and self-reported delinquency in accord with the ‘sinusoid curve hypothesis’. Moving around the value circle yields the highest negative correlations of self-reported delinquency with tradition and conformity and the highest positive correlations with hedonism and stimulation. These values are indicators of the higher-order value dimension ‘conservation’ versus ‘openness to change’. The significant impact of this value dimension on norm acceptance and delinquency is documented by means of SEM. 相似文献