A study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol

The possibility of post-mortem production of ethanol makes correct interpretation of ethanol detection in forensic autopsy samples difficult. Even though the levels of ethanol formed post-mortem are generally low, this may be highly relevant in cases where intake of alcohol was forbidden, for instance for pilots, professional drivers and countries with low legal alcohol limits for driving. Different criteria are used to determine whether a finding of ethanol is of exogenous origin, but there is no marker for alcohol ingestion that has been studied in detail. In this study, we wanted to evaluate the sensitivity and specificity of ethyl glucuronide (EtG), a direct minor metabolite of ethanol, measured in blood, as a marker of ante-mortem alcohol ingestion. Forensic autopsy cases were divided into groups with and without ante-mortem alcohol ingestion, according to strict inclusion criteria. In 93 cases with information on ante-mortem alcohol ingestion, EtG was detected in blood in all cases, even when levels of ethanol were low. In another 53 cases where there were no indications of ante-mortem alcohol intake, EtG could not be detected in blood in a single case, also in 11 cases in which ethanol was detected and considered to be most probably formed post-mortem. In conclusion, blood EtG determination seems to be a reliable marker of ante-mortem ingestion of alcohol, and it could be considered in forensic autopsy cases when post-mortem formation of ethanol is questioned.     

Never a final design: interviewing Norwegian alcohol smugglers

This paper presents a typology of respondents that have been encountered in interview-based research on the illegal alcohol market in Norway. Six distinct types (“the social talker”, “the expert witness”, “the flasher”, “the manipulator” and “the paranoid”) are distinguished and their relative value discussed from a scientific perspective. Students of organized crime must learn how to handle these characters both socially and analytically, and how to avoid certain pitfalls. Challenges a researcher may meet while studying organized crime will also be discussed, like “going nervous,” “going naïve”, “going native” and “going nonchalant”. Traditional Scandinavian literature on research methods has not been very helpful in this sense.     

Public Administration Research in Norway: Organization theory, institutionalism and empirical studies in a democratic context

This article gives a broad overview of Norwegian research on public administration over the past 40 years. The main picture that emerges is that a Norwegian public administration built primarily on Webernian principles has lost some but not all these original properties. It describes a research tradition based on organizational theory and democratic theory. It also paints a picture of public administration as integrated into a complex network of domestic political institutions, public agencies, organized interests and clients, as well as extensive European and international networks. It shows how a strong theoretical tradition, based on bounded rationality, is supplemented by different types of institutional theories and increased theoretical pluralism. Finally, the paper underlines the importance of considering public administration not simply from an internal technical viewpoint, but of placing the discipline in a wider political and democratic context.     

Controlling Regulatory Agencies

This article describes the regulatory agencies in Norway as part of the population of state agencies by focusing on who controls and what is controlled and how. The authors analyze whether regulatory agencies are regulated and controlled to different degrees, by different external actors, and in different ways than other agencies, and on whether this control focuses on different aspects. They also examine whether the variation in regulation and control according to type of agency task is sustained if one controls for structural and cultural features. The empirical basis is a broad survey of Norwegian state agencies carried out in 2004, and the theoretical approaches embrace a task-specific, a structural-instrumental and a cultural-institutional perspective. The authors find that regulatory tasks represent a major activity for state agencies in Norway and that external control by both the executive and the legislative bodies of agencies is rather significant. Moreover, in contrast to what one would expect, given current regulatory orthodoxy, regulatory agencies are controlled to a larger extent than other agencies.     

Keeping a watchful eye in times of turmoil? How repeated structural reform leads to more attention to political signals

An important rationale for the creation of semi-autonomous agencies is to create some distance between politics and administration. As such, agencies are expected to shield policy implementation from the daily concerns of political life. However, political actors and politically controlled ministries still influence agencies in various intended and unintended ways. This article focuses on intensive long-term series of structural reforms and how they may undermine the original design philosophy underpinning agencification. We utilize a dataset combining staff surveys and a structural reform database to perform multilevel analyses of employees nested in organizations. We find that the frequency with which agencies have experienced structural reform affects the weight that employees attach to signals from political and ministerial principals. Frequent structural reform may lead to heightened perceptions of the importance of political signals. Hence, frequent structural reforms may increase the risk of political influence on agencies that were designed to operate impartially.     

Relative effects of posture and activity on human height estimation from surveillance footage

Height estimations based on security camera footage are often requested by law enforcement authorities. While valid and reliable techniques have been established to determine vertical distances from video frames, there is a discrepancy between a person's true static height and their height as measured when assuming different postures or when in motion (e.g., walking). The aim of the research presented in this report was to accurately record the height of subjects as they performed a variety of activities typically observed in security camera footage and compare results to height recorded using a standard height measuring device. Forty-six able bodied adults participated in this study and were recorded using a 3D motion analysis system while performing eight different tasks. Height measurements captured using the 3D motion analysis system were compared to static height measurements in order to determine relative differences. It is anticipated that results presented in this report can be used by forensic image analysis experts as a basis for correcting height estimations of people captured on surveillance footage.     

Polytraumatization and trauma symptoms in adolescent boys and girls: interpersonal and noninterpersonal events and moderating effects of adverse family circumstances

The objective of this study was to investigate the cumulative effect of interpersonal and noninterpersonal traumatic life events (IPEs and nIPEs, respectively) on the mental health of adolescents and to determine if the adverse impacts of trauma were moderated by adverse family circumstances (AFC). Adolescents (mean age 16.7 years) from the normative population (n = 462) completed the questionnaire, the Link?ping Youth Life Experience Scale (LYLES), together with Trauma Symptom Checklist for Children (TSCC). The lifetime accumulation of interpersonal, noninterpersonal, and AFC was independently related to trauma-related symptoms in both boys and girls. The number of AFCs moderated the mental health impact of both IPEs and nIPEs in boys but not in girls. Cumulative exposure to both interpersonal and noninterpersonal traumatic events is important for the mental health of adolescents, and, at least for boys, family circumstances seem to be relevant for the impact of trauma. Our results suggest that broader approaches to the study, prevention, and treatment of trauma, including consideration of cumulative exposure, different types of trauma, and additional social risk factors, could be fruitful.     

Cytochrome P450 2D6 (CYP2D6) genotyping on postmortem blood as a supplementary tool for interpretation of forensic toxicological results

Debrisoquine hydroxylase (CYP2D6) is involved in the metabolism of many toxicologically important drugs. The gene encoding for this enzyme displays a polymorphic distribution in all populations examined. We report a study on 46 cases, where analyses of the CYP2D6 gene were conducted on postmortem femoral blood in order to investigate the occurrence of poor metabolizers (PM). A polymerase chain reaction (PCR) method, designed and routinely used for therapeutic drug monitoring, was employed, only slightly modified. Samples from 22 cases, where the parent drug to metabolite ratio was unexpectedly high were analyzed as well as samples from 24 control cases. Genotyping could be carried out in all but one case. Previous freezing or addition of potassium fluoride as preservative did not prevent analysis. Only one PM (from the control group) was discovered, implying an occurrence of only 2.2% as compared to the reported frequency of approx. 7% in Sweden. Among the extensive metabolizers (EM), however, a number of individuals with mutated genes were identified. Although it seems reasonable to suspect a PM genotype in cases with a high concentration of a drug metabolized by CYP2D6, but without suspicion of acute overdose, our study does not support the opinion that this interpretation pitfall is particularly common. This study rather indicates that drug interactions in EMs constitute a more frequent and important problem.     

Participation in local politics in Norway: Some do,some don't; some will,some won't

Using data from two national surveys conducted in 1990 and 1993, this article investigates seven modes of sociopolitical behavior and one form of potential political participation in the context of Norwegian local government. Results indicate that factors associated with alternative modes of activity vary; different types of people tend to choose different channels of involvement. The most pronounced difference is found between activities directed toward influencing public opinion and those intended to influence political decision making more directly. Whereas the former mode is more typically chosen by younger, well-educated single women living in urban areas, the latter is more characteristic of married, better educated men living in smaller municipalities. Findings are characterized by a high degree of stability over the period considered. Only in the case of voting is there a suggestion of some possible change. After decades in which socioeconomic status variables have been of little significance for voting in Norway (a situation explained by the mobilizing effects of organizations), an effect of education was found in the 1993 survey. Also noteworthy is the distribution of participation among the population: rather than being cumulative, different forms of political involvement are relatively widespread.