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141.
While analyzing the available published data, we found significant differences in definition of alleles of the HUMCD4 polymorphic chromosome locus. It is an obstacle for comparing the expertise results obtained while using the locus as molecular individualization system in different laboratories and, as a consequence, it hinders the use of the said marker in building up a reference database. The structure of the HUMCD4 locus was analytically investigated and the distribution of the locus alleles was systemized in a sample of 407 persons (citizens of Russia who are not blood relatives) within the present case study for the purpose of a detailed definition of its allele's characteristics. We worked out recommendations related with the nomenclature standardization of alleles of the HIMCD4 locus and specified the main population features of the locus polymorphism on the bases of the studied sample of Russia's citizens. The results can be used as reference parameters in interpreting the findings of the molecular-genetic identification expertise and examinations and in building up databases. 相似文献
142.
Data are reported on toxicity of a majority of non-steroid anti-inflammatory drugs (NSAD), which are the most frequently used in clinical practice and whose chemical structures are different. The action mechanism and side effects of some NSAD, in particular, of diclofenac, ibuprofen and indometacin, are also in the focus of attention. 相似文献
143.
Allelic frequencies of chromosome micro-satellite locuses D16S539, F13B, FESFPS, TH01 and TPOX were determined, within the case study, in a sampling of Europeoidal individuals residing in Russia's Ural Region. The allelic variants were analyzed by capillary electrophoresis after the enzyme amplification in polymerase chain reaction with fluorescent primers. The genotypic frequencies of the studied locuses were shown not to divert with statistical reliability from Hardy-Weinberg equilibrium. The estimated aggregate discriminative potential for a panel of 5 studied locuses made 0.99995. No nonequilibrium was found by linkage between alleles of all lucuses examined within the present case study or between their alleles and the alleles of previously investigated locuses D7S820 and D13S317. The implemented testing of the population homogeneity of allelic frequencies of investigated locuses for 3 samplings of Europeoids showed a deviation for locus FESFPS versus the Ural and Polish samplings and for locus F13B in the Ural and North America samplings. The distribution of allelic frequencies of other locuses was homogenous in the compared samplings. 相似文献
144.
The shaped-up experience of management and implementation of expertise as applicable to civil and criminal cases and with respect to the requirements of new legislative acts was analyzed. Issues connected with composing a commission of experts, with the range of competence of forensic medical expert and of clinical practitioner, as well as with the content and form of the expert conclusions are under discussion. 相似文献
145.
146.
Y-STR polymorphism in Central Anatolian Region of Turkey 总被引:2,自引:0,他引:2
Rustamov A Gümüş G Karabulut HG Elhan AH Kadikiran A Bökesoy I 《Forensic science international》2004,139(2-3):227-230
Eight Y-chromosome specific STR (Y-STR) loci including DYS19, DYS388, DYS389I, DYS389II, DYS390, DYS391, DYS392 and DYS393 were investigated in a group of males from Central Anatolian Region of Turkey. Healthy 59 males living in this region for at least three generations were included in the study. PCR analysis was carried out with Y-STR specific primers on genomic DNA obtained from peripheral blood samples and size determination of PCR products was performed by silver staining following 6% polyacrylamide gel electrophoresis (PAGE). DYS388 was found to be the locus with lowest diversity (D) whereas DYS389II was the locus with highest diversity. The current study presented a framework of variation for the eight Y-STR loci in Central Anatolian population. 相似文献
147.
148.
Sexual differences in the human skeleton have been well studied in many populations. Odontometric analysis of the human sexual variation has been less investigated and mostly derived from the dentition of extinct populations. Turkey is situated in a unique location where populations from different regions mixed with each other and created a rich gene pool. One might anticipate that modern Turkish population is composed of genes from the Balkans, Caucasus, Middle East, Iran and further as well as from ancient Romans, Byzantines, Arabs and Asiatic Turks. It is clear that contemporary Turks are a mixture of these extant and extinct people and ideal to consider it a representative study population. The purpose of this study is to analyze dental dimensions and sexual variation in living Turks and develop forensic techniques to identify human remains from the teeth when any other technique is not available or not reliable. The study is composed of Ankara University dental students (50 male and 50 female casts, average age of 21 years). Bucco-lingual breadths from 14 teeth (I1 through M2 of the maxilla and mandible) are taken from the left side and analyzed using the discriminant function statistics. An intraobserver error test did not indicate any statistically significant difference between any two measurements. Results of the study revealed that males exceeded females significantly (P<0.001) in dimensions. Coefficient of variation was most obvious in I1s and I2s of both jaws in both sexes. Stepwise discriminant function statistics suggested that upper C, and lower C and M2 are the most contributory teeth to the function. Additional formulae were calculated for situation in which only one or a fragmented jaw is available for identification. Overall accuracy of sex diagnosis ranged from 73 to 77%. In conclusion this research supports earlier studies that sexual dimorphism is population specific. While dental difference between the sexes in several human populations has been found highly dimorphic, it was not found so in Turks and accuracy of classification remained low at about 77%. The difficulty or the lack of dimorphism comes from male subjects. 相似文献
149.
150.
Anghel A Marian C Pitulescu M Daba A Sirbu IO Rusu V Budowle B 《Forensic science international》2003,131(2-3):218-219
Allele frequencies for eight tetranucleotide short tandem repeat (STR) loci-CSF1PO, TPOX, TH01, F13A01, FESFPS, vWA, F13B, LPL-were obtained from a population sample of 105-122 unrelated individuals born in Transylvania and Banat (Romania). 相似文献