Sudden cardiac death in young adults: environmental risk factors and genetic aspects of premature atherosclerosis

Familial hypercholesterolemia (FH) is a genetic disorder that may lead to premature coronary heart disease (CHD) and sudden cardiac death (SCD). Mutations in the LDLR or APOB genes cause FH. We have screened the LDLR and the ligand-binding region of APOB genes in 52 cases of SCD. Deceased patients were younger than 40 years of age and were suspected of having FH. The LDLR and APOB genes were examined via PCR, high-resolution melting, and DNA sequencing. Therein, it was observed that 7.7% of the screened patients exhibited a rare sequence variant in the LDLR gene, with 5.7% suspected of being pathogenic mutations. Lipid profiles and genetic testing for FH could be considered when autopsy reveals significant atherosclerosis of the coronary arteries in young adults. First-degree family members are advised to seek medical advice and testing to determine their own risks of atherosclerosis to prevent premature CHD and SCD.     

Workplace violence in Hong Kong, China: nature, impact, and preparedness

This article reports a survey of workplace violence in Hong Kong. A sizable number of the 1,198 organizations that were questioned reported that they had experienced such violence over the 2 years preceding the study, but the problem was not prevalent. In both the private and government sectors, nonphysical violence happened more frequently than physical violence, and there was a reported lack of preparedness of many organizations to deal with the violence. Compared with private organizations, government organizations experienced more coworker and customer violence, but more private than government organizations believed that workplace violence caused the loss of key employees and clients. Correlation analysis found that a subculture of workplace violence appears to emerge over time, such that the more customer violence is experienced, the more is coworker violence, and the more the nonphysical violence, the more the physical violence. These findings are discussed with reference to international findings.     

The Life and Death of UDAG: An Assessment Based on Eight Projects in Five New Jersey Cities

The federal Urban Development Action Grant program, begun in1977, provided $5 billion over eleven years revitalizing severelydistressed urban places through the encouragement of privatesector investment. Designed to assist commercial, industrial,and housing projects that "but for" the federal grant wouldnot be built, the program was characterized by a streamlinedgrant-making process administered by finance and developmentexperts. Eight UDA G projects in five New Jersey cities, firststudied in the proposal stage in 1979 and revisited in 1987,show that the UDAGs succeeded in attracting development to thesehard-pressed cities. Although the projects succeeded, the programwas unable to arrest the more general distressed conditionsof the cities. During the Reagan years, the administration soughtto end the program. Congress supported it, but reduced the fundingeach year. In an effort to gain support for the program, eligibilityrequirements were broadened to include more localities. Theseefforts failed, and in 1988 Congress did not fund the program.Despite its demise, UDAG is recognized as having stimulatedurban revitalization and having created a new model for privatesector and public sector collaboration in economic development.     

Rhetoric and Action in Regulating the Public Schools in Norway and Sweden

In the past few decades, Norway and Sweden, like the rest of the Western world, have attempted to restructure and deregulate education. In both countries, the established governing models were threatened due to lack of legitimacy and efficiency. This article discusses the extent to which the different explanations of stability and institutional change address what happened when Management by Objectives and Results (MbOR) was introduced in Norway and Sweden. However, both the content and the course of change were different in the two countries. More specifically, one can talk about processes combining lock‐in mechanism and layering in the Norwegian course of development. In Sweden, the process of change was characterized by sudden and radical decisions. A decision made in 1991 could be explained as a state of punctuated equilibrium, as strong forces produced a situation where nothing else was to be done except make a radical change, turning the centralized system into a decentralized one. The period has parallels to the concept of ‘critical juncture’, representing a moment of openness to and possibility for different and new actors to influence a new constitution. In Norway, the transformation of policy tools for education purposes has thus far dominated the process and direction of change. In Sweden, through processes of conversion, the policy tool has gained a more dominating influence over education policy. Accordingly, there was a stronger emphasis on MbOR in its original version in Sweden than in Norway, which has transformed and defined the concept in line with educational purposes. This article outlines two cases of institutional change that combine elements of lock in with new developments. In neither Norway nor Sweden was the development pushed further in the same trajectory, rather it was transformed and, in the case of Sweden, radically changed within a larger nationally specific framework of sequence of events, values, norms and traditions of policy making.     

Perceptions of Public Security in Post-reform Urban China: A Routine Activity Analysis

This paper investigates the personal and environmental determinants of public security perceptions across 32 Chinese cities within the risk/opportunity framework of Cohen and Felson’s (American Sociological Review 44:588–608, 1979) routine activity theory. Structural path analysis reveals that public security perceptions in China are informed by similar personal and environment characteristics to those reported as important in extant research within Western contexts. However, the frequently reported influence of gender on public security perceptions in the West does not appear to extend to post-reform urban China. The results provide support for the routine activity theory in terms of extending our understanding of the factors that influence perceptions of public security to a non-Western context.     

Who Can Deviate from the Party Line? Political Ideology Moderates Evaluation of Incongruent Policy Positions in Insula and Anterior Cingulate Cortex

Political polarization at the elite level is a major concern in many contemporary democracies, which is argued to alienate large swaths of the electorate and prevent meaningful social change from occurring, yet little is known about how individuals respond to political candidates who deviate from the party line and express policy positions incongruent with their party affiliations. This experiment examines the neural underpinnings of such evaluations using functional MRI (fMRI). During fMRI, participants completed an experimental task where they evaluated policy positions attributed to hypothetical political candidates. Each block of trials focused on one candidate (Democrat or Republican), but all participants saw two candidates from each party in a randomized order. On each trial, participants received information about whether the candidate supported or opposed a specific policy issue. These issue positions varied in terms of congruence between issue position and candidate party affiliation. We modeled neural activity as a function of incongruence and whether participants were viewing ingroup or outgroup party candidates. Results suggest that neural activity in brain regions previously implicated in both evaluative processing and work on ideological differences (insula and anterior cingulate cortex) differed as a function of the interaction between incongruence, candidate type (ingroup versus outgroup), and political ideology. More liberal participants showed greater activation to incongruent versus congruent trials in insula and ACC, primarily when viewing ingroup candidates. Implications for the study of democratic representation and linkages between citizens’ calls for social change and policy implementation are discussed.     

Parental Predictors of Motivational Orientation in Early Adolescence: A Longitudinal Study

Using latent variable path analysis with partial least squares (LVPLS), the study examines the pathways between parenting practices and children's motivational orientation toward school work over the transition to middle school. Greater external control and lack of guidance by parents in the 5th-grade year were related to children's poorer academic achievement that year, which in turn predicted a more extrinsic motivational orientation in 7th grade. In contrast, greater parental autonomy-supporting behavior in the 5th-grade year was related to children's higher academic achievement that year, which in turn predicted a more intrinsic motivational orientation in 7th grade. In all instances, children's perceptions of their academic competence mediated the relation between 5th-grade academic performance and 7th-grade motivational orientation. Associate Professor, Division of Child and Adolescent Psychiatry, Johns Hopkins University, School of Medicine. Her current research focuses on anxiety and depression in childhood.     

PROPOSAL FOR A PILOT EDUCATION PROGRAM FOR DIVORCING AND SEPARATING PARENTS

This article presents the proposal made to the Clackamas County Board of Commissioners outlining the rationale for the Clackamas County Parent Education Program. including a proposed budget and sources of income.