Application of solid-phase microextraction to the profiling of an illicit drug: manufacturing impurities in illicit 4-methoxyamphetamine

This article describes the application of solid-phase microextraction (SPME) to the recovery of manufacturing by-products and impurities from an illicit drug seizure. The preparation chosen for examination using this technique contained 4-methoxyamphetamine, an hallucinogenic amphetamine that has been encountered frequently in South Australia. Compounds found in the PMA preparation included 4-methoxyphenol, 4-methoxybenzaldehyde, 4-methoxyphenyl-2-propanone, 4-methoxyphenyl-2-propanol, 4-methoxyphenyl-propene, and (tentatively) 4-methyl-5-(4'-methoxyphenyl) pyrimidine. The presence of these compounds suggests that the active drug was prepared from 4-methoxybenzaldehyde via 4-methoxyphenyl-2-propanone using a Leuckardt reductive amination. In this instance, SPME was found to be a simple, rapid, and non-destructive recovery technique that gave results complementary to those provided by conventional liquid-liquid extraction. There is an indication that SPME might find application in profiling of illicit drugs.     

Alcohol content of beer and malt beverages: forensic consideration

Beer consumption is commonly an issue in a medico-legal setting, requiring estimates either of a likely blood alcohol concentration (BAC) for a given pattern of consumption or vice versa. Four hundred and four beers and malt beverages available for sale in the State of Washington were tested by gas chromatography for their alcohol content. Considerable variability in the alcoholic strength was found, even within the same class. Overall the range of concentrations was 2.92%v/v to 15.66%v/v. The mean alcohol concentration for ales was 5.51%v/v (SD 1.23%v/v), and for lagers, 5.32% (SD 1.43%v/v). Some specialty brews had characteristically higher or lower mean concentrations: ice beers 6.07%v/v, malt liquor 7.23%v/v, light beer 4.13%v/v, seasonal ales 6.30%v/v. Six brands of lager and four light beers account for the majority of all beer sales in the United States, and the mean alcohol concentration for these products was measured as 4.73%v/v and 4.10%v/v respectively. Few of the beers (17%) were labeled with respect to alcohol content, and in some cases, there was a significant disparity between the concentration listed on the label, and the measured alcohol concentration. Toxicologists need to exercise caution when performing Widmark type calculations, using all available information to select the most appropriate estimate for alcoholic strength of a beer or malt beverage.     

Toward an understanding of the perception of hiv/aids-related risk among prison officers

One consequence of the drug war has been the incarceration of many offenders who pose a health risk to staff. This article presents an analytical framework to examine the factors that influence staffs' perceptions of the threat of infection. Four risk domains influence an officer's self-rated threat of exposure: (1) psychosocial factors, (2) HIV/AIDS-related knowledge, (3) perception of risk in the prison environment, and (4) risk reduction efforts. Officers with lower levels of education, those who worked with medium and maximum custody inmates, and those who had more high-risk encounters with inmates rated their chances for infection as high. Findings are discussed in light of their practical and theoretical applications.     

The morphofunctional changes in the internal organs in the modelling of poisonings by psilocybine-containing mushrooms]

Histological analysis of the viscera in experimental poisoning with psilocybin-containing mushrooms showed nonspecific changes in all examined organs, presenting as expressed hemocirculatory disorders and intracellular dystrophy. Quantitative histochemical analysis showed appreciable shifts in the activities of enzymes involved in the cytoplasmic and mitochondrial redox processes and of specific enzymes involved in nerve tissue metabolism. This may reflect some features in the direct effects of narcotic alkaloids contained in psilocybin-producing mushrooms.     

Lethal poisoning with ethyl alcohol and its surrogates in various regions of the Russian Federation

The index of lethal poisoning with ethyl alcohol and its surrogates in Russia remains one of the highest in the world. It is explained by high alcohol consumption in Russia (about 15 liters of pure alcohol per capita annually), consumption of mainly strong beverages (about 80%), extensive sales of adulterated strong alcoholic beverages (more than 25%), virtually no preventive work in the population, and other causes. The index of lethal poisoning with alcohol and its surrogates in the country and its regions is one of the most important parameters in evaluation of the socioeconomic well-being of the population.     

Competence to Stand Trial: A Neuropsychological Inquiry

Law and Human Behavior - How might the deconstruction of the legal theory of competence be related to modern neuropsychological models of cognition? To address this question, we examined...     

The social,behavioral, and health effects of phencyclidine (PCP) use

This study examined the perceived social, behavioral, and health effects of phencyclidine (PCP) use among a sample of 200 users in northern California. The study population, generated through snowball sampling techniques, included heavy chronic, light chronic, and recreational users; the vast majority of subjects were not in treatment facilities. Subjects reported that PCP use—particularly long-term, extensive use—resulted in frequent disruption of education and employment, impairment of relationships with parents and with lovers or spouses, involvement with the criminal justice system, and deterioration of physical and mental health. These findings provide systematic documentation of the extent to which problems previously associated with PCP use occurred among this population of users. In addition, the results illustrate the importance of examining the effects of PCP use in light of the psychosocial developmental processes of adolescence and early adulthood.This research was supported by Research Grant No. DA02293 from the National Institute on Drug Abuse.Received M.S. in psychology from California State University, Hayward.Received Ph.D. from University of Iowa.     

The latin american business environment: patent protection issues

Considers the issue of patent rights in Argentina, Brazil, Chile, and Mexico. Reviews both theoretical and empirical literature on fitting patent systems to national circumstances. Data are considered shedding light on trade flows and capital formation, two areas impacted by strong or weak protection. Recommends a general hybrid system for Latin American nations, meeting GATT standards while remaining adaptable to individual country needs.