High‐throughput sequencing (HTS) of large panels of single nucleotide polymorphisms (SNPs) provides an alternative or complimentary approach to short tandem repeats (STRs) panels for the analysis of complex DNA mixture forensic samples. For STRs, methods to estimate individual contribution concentrations compare capillary electrophoresis peak heights, peak areas, or HTS allele read counts within a mixture. This article introduces three approaches (mean, median, and slope methods) for estimating individual DNA contributions to forensic mixtures for HTS/massively parallel sequencing (MPS) SNP panels. For SNPs, the major:minor allele ratios or counts, unique to each contributor, were compared to estimate contributor proportion within the mixture using the mean, median, and slope intercept for these alleles. The estimates for these three methods were typically within 5% of planned experimental contributions for defined mixtures. 相似文献
This article focuses on whether the provision of 'objectively' correct information to voters about where parties stand on an issue affects their placement of the parties, and ultimately their own position, on that issue. Classic theories of how mass publics make voting decisions assume that voters are able relatively accurately to place themselves and the parties on various issue dimensions. While these assumptions have been challenged, it is generally assumed that the provision of new information makes voters' placements more informed. We explicitly test this idea using a survey experiment focusing on one political issue – European integration. In the experiment, all respondents were twice asked to place the three main British parties and themselves on a bipolar scale of European integration. This was done towards the beginning, and then at the end of the survey. Most respondents were also given information on the 'informed' positions of the parties, derived from expert survey placement. Our analyses indicate that individuals' placements did change, and the tendency was related to both political sophistication and the inherent difficulty of placing the party. Only less sophisticated voters updated their placements, and these changes are concentrated on the placement of the Labour party, where the elite stance on Europe has been more conflicted. For all respondents we do not detect any corresponding changes in self-placement that would be congruent with 'cueing' effects. 相似文献
It is shown in this article how theories justifying local government in Britain are largely based on the expedience of providing administrative efficiency or stable democracy for the central state rather than ethical grounds that justify local government as an independent entity in its own right. The article critically reviews the development of theories justifying local government within Britain and argues that it is possible on the basis of Mill's arguments within On Liberty to establish a strong ethical justification for local government. It is shown how Mill did not develop this line of thought but established substantive arguments concerning the value of local government for securing a stable liberal democracy and how successive mainstream theorists have modified but not substantially departed from this approach. 相似文献
We investigate the political economy of IMF forecasts with data for 157 countries (1999–2005). Generally, we find evidence of forecast bias in growth and inflation. Specifically, we find that countries voting with the United States in the UN General Assembly receive lower inflation forecasts as domestic elections approach. Countries with large loans outstanding from the IMF also receive lower inflation forecasts, suggesting that the IMF engages in “defensive forecasting.” Finally, countries with fixed exchange rate regimes receive lower inflation forecasts, suggesting the IMF desires to preserve stability as inflation can have detrimental effects under such an exchange rate regime. 相似文献
Communication within friendship networks can provide gains in efficiency that help individuals enrich their understanding of politics. Through two panel survey experiments, we demonstrate that the dissemination of an individual's opinion about the hazards posed by public policies can have both durable and significant effects on the policy judgments of friends. These effects are conditioned by both the content of the communication and the recipient's level of political awareness. Opinions emphasizing potential risks carry more weight than those that attempt to alleviate concerns about potential risks. Moreover, opinion transmission is more effective for subjects who are less politically aware when policy issues are salient; but when the political issue is more esoteric, friends who are more politically aware evidence greater opinion change. 相似文献
This essay questions the soundness of a scholarly shift awayfrom refugee studies in favour of forcedmigration studies. It contends, first, that subsumingrefugee studies into the broader framework of forced migrationstudies may result in a failure to take account of the specificityof the refugee's circumstances which are defined not just bymovement to avoid the risk of harm, but by underlying socialdisfranchisement coupled with the unqualified ability of theinternational community to respond to their needs. Second, itargues that forced migration (rather than, forexample, forced migrant) studies encourages afocus on a phenomenon rather than on the personal predicaments,needs, challenges, and rights of refugees themselves. It maythus contribute to a lack of criticality in relation to policieswhich subordinate refugee autonomy to the pursuit of more systemicconcerns. The first concern is illustrated by reference to theemergence of the internally displaced personscategory, the second by reference to the determination to findand mandate durable solutions to forced migration,including to the movement of refugees. 相似文献
Hacking trauma is prevalent in forensic cases involving genocide and dismemberment, but research into the identification of this type of trauma is lacking. The present study examines characteristics of hacking and blunt force skeletal trauma in order to determine if there is a point at which blunt force trauma becomes distinguishable from hacking trauma. Ten implements with a range of blade angles (i.e., the striking surface of the implement) were used in conjunction with a controlled-force hacking device to impact 100 limb bones of white-tailed deer (Odocoileus virginianus). Observations of the trauma included the occurrence and degree of fragmentation, the entrance widths of the impacts, and composite scores of six hacking characteristics, especially the distinctive V-shaped kerf. ANOVA tests and regression analyses were used to assess the relationships between these characteristics and the blade angles. A significant relationship (p-value = 0.011) was found between the composite hacking scores and the blade angles, indicating that blunt force and hacking trauma can be distinguished. The entrance widths of the impacts exhibited a significant relationship with the blade angles (p-value = 0.037). There was also a significant relationship between the visibility of a V-shaped kerf in the bones (p-value = 0.003), with visibility decreasing around the 60° blade angle. These data should assist in establishing guidelines to differentiate hacking and blunt force skeletal trauma in cases where the implement is on a spectrum between sharp and blunt. 相似文献
There are important studies that have directly focused on how, in times of conflict, it is possible for previously law abiding people to commit the most atrocious acts of cruelty and violence. The work of Erich Fromm (Escape from Freedom), Hannah Arendt (Eichmann in Jerusalem), Zygmunt Bauman (Modernity and the Holocaust) and Ernest Becker (Escape from Evil) have all contemplated the driving force of aggression and mass violence to further our understanding of how people are capable of engaging in extreme forms of cruelty and violence. This paper specifically addresses these issues by focusing on C. P. Taylor’s play Good. This provocative play examines how a seemingly ‘good’ and intelligent university professor can gradually become caught up in the workings of the Third Reich. Taylor highlights the importance of appreciating how people can be steadily incorporated into an ideologically destructive system. I argue that the theatre is a powerful medium to explore these complex issues. The audience of Good find themselves confronted with the following question—‘What would you have done?’