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601.
Laloup M Tilman G Maes V De Boeck G Wallemacq P Ramaekers J Samyn N 《Forensic science international》2005,153(1):29-37
The use of amphetamine and 'ecstasy' (MDMA) has increased exponentially in many European countries since the late nineties, leading to a rapid growth in the number of clinical and forensic analyses. Therefore, a rapid screening procedure for these substances in biological specimens has become an important part of routine toxicological analysis in forensic laboratories. The objective of this study was to evaluate the Cozart amphetamine enzyme-linked immunosorbent assay (ELISA) for the screening of plasma samples and oral fluid samples (collected with the Intercept device). Authentic plasma samples from drivers (n=360) were screened, using an 1:5-fold dilution. True positive, true negative, false positive and false negative results were determined relative to the in-house routine GC-MS analysis. Samples consisted of 144 amphetamine-only positives, 141MDMA/MDA-only positives, and 74 negatives when using the limit of quantitation as the cut-off level for confirmation (10 ng/mL). Using these results, receiver operating characteristic (ROC) curves were generated and optimal cut-off values for the screening assay were calculated. Analysis showed that the ELISA is able to predict the presence of either amphetamine or *MDMA/MDA (*MDMA as its metabolite MDA) in plasma samples with 98.3% sensitivity and 100% specificity at a cut-off value of 66.5 ng/mL d-amphetamine equivalents. A similar analysis was conducted on 216 oral fluid specimens collected from a controlled double blind study. Subjects received placebo or a high (100 mg) or low (75 mg) dose of MDMA. Oral fluid samples were collected at 1.5 and 5.5h after administration. Combined results of the analysis of the high and low dose oral fluid samples indicated a screening cut-off of 51 ng/mL d-amphetamine equivalents with both a sensitivity and specificity of 98.6% (using a LC-MS/MS confirmation cut-off of 10 ng/mL). In conclusion, these data indicate that the Cozart AMP EIA plates constitute a fast and accurate screening technique for the identification of amphetamine and MDMA/MDA positive plasma samples and oral fluid specimens (collected with Intercept. It should be emphasized that method validation should be performed for each type of biological matrix. 相似文献
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605.
Quantitative ratings of policies of national governments are an important tool for the monitoring of compliance with international standards in many domains. In this article we present a global index of anti-human trafficking policies developed by a research consortium using the TIP country reports of the U.S. State Department (the 3P index) and an index based on the reports of the monitoring body of the Council of Europe Convention against Human Trafficking (GRETA). Although the global 3P index gives more favorable ratings to most European countries than the GRETA-based index, a moderately strong correlation was found between the two indices. This is an encouraging result lending support to the validity of the assessments of both monitoring mechanisms as well as to their transformation into quantitative scores. We also demonstrate that the detailed GRETA-based index can be used to identify best practices in anti-trafficking policies and specific areas where these policies are most in need of improvement, e.g. legal aid and compensation for victims. Our analyses of the relationships between the various items of the index revealed positive correlations between the existence of units of specialized prosecutors and the numbers of convictions of traffickers. Our paper, then, demonstrates the potential of quantitative indices of counter human trafficking policies as tools for both effective monitoring of the implementation of international standards and for analytical purposes. 相似文献
606.
Martin Nekola Jan Kohoutek 《Canadian public administration. Administration publique du Canada》2016,59(2):289-309
This paper uses data from two countries to develop profiles of policy directors and managers in the sub‐national public bureaucracies of Canada and the Czech Republic. Canadian directors and managers undertake more analytically complex tasks for which research and evaluation is necessary. In comparison, Czech managers are more firmly engaged in project management agendas, and Czech directors tend to rely on personal experience and routine approaches. Overall, the sample shows that different policy styles are emphasized in each country and at different levels ranging from rational‐technical and advisory‐interactive (Canadian directors and managers), process expertise (Czech managers), and a combination of analytical rationality and issue activism (Czech directors). 相似文献
607.
AbstractRecent years have seen a deterioration in political relations between China and Japan, in particular over the disputed Senkaku/Diaoyu islands and history-related problems. Commentators have noted an attendant decline in trust between the two sides and have stressed the need for confidence-building measures in order to address the trust deficit. This article explores the origins of declining trust between the Chinese and Japanese leaderships. It argues that attempts to build a friendly and trusting relationship in the early post-war and post-normalisation periods began to fail in the 1980s, and have been in a gradual state of decline ever since. Using the concepts of trust and friendship, the article suggests that the lack of trust properties such as empathy, bonding, reliability and predictability have contributed to the deterioration of trust at both elite and popular levels. 相似文献
608.
Issues about corruption and other forms of ‘bad government’ have become central in large parts of the social sciences. An unresolved question, however, is how countries can solve the issue of systemic corruption. In this article, based on Elinor Ostrom's theory of common pool resource appropriation, a new theoretical model for explaining this type of institutional change is developed. Sweden during the nineteenth century is used as an illustration of the model by showing how the country made a transition from being largely patrimonial, nepotistic and corrupt to a modern, Weberian, efficient and impartial state structure. Building upon a companion article about the importance of losing a war as a precondition for breaking systematic corruption, this article stresses the importance of three additional factors in Sweden: previous changes in courts and the legal system; recognition of the problem by the main contemporary political actors as shown in debates in the Diet; and the new liberal ideology that made an important impact on the Swedish political scene during this period. 相似文献
609.
Jan Priebe 《发展研究杂志》2018,54(4):657-681
Disability profiles showing how the magnitude of disability differs across subgroups of a population are important tools in designing effective policies. Yet little is known about the sensitivity of the correlates of disability to the way disability is measured. This study uses an unprecedentedly large amount of nationally representative survey data from Indonesia. Based on 13 different datasets that were collected between 2000 and 2014, and which together contain disability information on more than 1 billion individuals, we assess how robust disability profiles are to measurement issues. Our findings suggest that irrespective of the dataset and measure used, disability is disproportionally more common among the poor, the elderly and rural areas in the country. Hence, Indonesian policies on poverty reduction, population ageing, and rural development should pay particular attention to how they reach and affect persons with disabilities. Our research further reveals that the gender gap in disability is highly sensitive to measurement issues with different datasets and measures reaching different conclusions about the size and direction of the gap. 相似文献
610.
Jan Johnston 《Family Court Review》2012,50(4):543-544