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611.
Laloup M Tilman G Maes V De Boeck G Wallemacq P Ramaekers J Samyn N 《Forensic science international》2005,153(1):29-37
The use of amphetamine and 'ecstasy' (MDMA) has increased exponentially in many European countries since the late nineties, leading to a rapid growth in the number of clinical and forensic analyses. Therefore, a rapid screening procedure for these substances in biological specimens has become an important part of routine toxicological analysis in forensic laboratories. The objective of this study was to evaluate the Cozart amphetamine enzyme-linked immunosorbent assay (ELISA) for the screening of plasma samples and oral fluid samples (collected with the Intercept device). Authentic plasma samples from drivers (n=360) were screened, using an 1:5-fold dilution. True positive, true negative, false positive and false negative results were determined relative to the in-house routine GC-MS analysis. Samples consisted of 144 amphetamine-only positives, 141MDMA/MDA-only positives, and 74 negatives when using the limit of quantitation as the cut-off level for confirmation (10 ng/mL). Using these results, receiver operating characteristic (ROC) curves were generated and optimal cut-off values for the screening assay were calculated. Analysis showed that the ELISA is able to predict the presence of either amphetamine or *MDMA/MDA (*MDMA as its metabolite MDA) in plasma samples with 98.3% sensitivity and 100% specificity at a cut-off value of 66.5 ng/mL d-amphetamine equivalents. A similar analysis was conducted on 216 oral fluid specimens collected from a controlled double blind study. Subjects received placebo or a high (100 mg) or low (75 mg) dose of MDMA. Oral fluid samples were collected at 1.5 and 5.5h after administration. Combined results of the analysis of the high and low dose oral fluid samples indicated a screening cut-off of 51 ng/mL d-amphetamine equivalents with both a sensitivity and specificity of 98.6% (using a LC-MS/MS confirmation cut-off of 10 ng/mL). In conclusion, these data indicate that the Cozart AMP EIA plates constitute a fast and accurate screening technique for the identification of amphetamine and MDMA/MDA positive plasma samples and oral fluid specimens (collected with Intercept. It should be emphasized that method validation should be performed for each type of biological matrix. 相似文献
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Jan Aart Scholte 《Democratization》2013,20(4):52-77
Post‐communist transition in Romania has witnessed an accelerated globalization in the country. Global (understood here as supraterritorial) relations have altered many communication networks, forms of organization, production processes, markets, monetary and financial flows, ecological conditions, and patterns of social consciousness. Although the extent of globalization in Romania should not be exaggerated, the recent rapid spread of supraterritoriality has pulled the country out of the preceding era of territorialist politics. The Romanian state can no longer realize its claims to sovereignty and has become oriented to transborder as well as territorial constituencies. At the same time, globalization has stimulated greater involvement of transworld and regional agencies in governance. The rise of supraterritoriality has also encouraged some devolution and some privatization of regulatory authority in Romania. Singly and together, these developments pose substantial challenges for democracy. True, certain transborder initiatives have modestly promoted post‐communist democratization in Romania. On the whole, however, Romanians have obtained insufficient participation, consultation, representation, transparency and accountability in respect of the multi‐layered and fragmented governance that is emerging in the context of globalization. 相似文献
615.
AbstractRecent years have seen a deterioration in political relations between China and Japan, in particular over the disputed Senkaku/Diaoyu islands and history-related problems. Commentators have noted an attendant decline in trust between the two sides and have stressed the need for confidence-building measures in order to address the trust deficit. This article explores the origins of declining trust between the Chinese and Japanese leaderships. It argues that attempts to build a friendly and trusting relationship in the early post-war and post-normalisation periods began to fail in the 1980s, and have been in a gradual state of decline ever since. Using the concepts of trust and friendship, the article suggests that the lack of trust properties such as empathy, bonding, reliability and predictability have contributed to the deterioration of trust at both elite and popular levels. 相似文献
616.
Martin Nekola Jan Kohoutek 《Canadian public administration. Administration publique du Canada》2016,59(2):289-309
This paper uses data from two countries to develop profiles of policy directors and managers in the sub‐national public bureaucracies of Canada and the Czech Republic. Canadian directors and managers undertake more analytically complex tasks for which research and evaluation is necessary. In comparison, Czech managers are more firmly engaged in project management agendas, and Czech directors tend to rely on personal experience and routine approaches. Overall, the sample shows that different policy styles are emphasized in each country and at different levels ranging from rational‐technical and advisory‐interactive (Canadian directors and managers), process expertise (Czech managers), and a combination of analytical rationality and issue activism (Czech directors). 相似文献
617.
This Viewpoint essay examines university research administration and the use of software systems that automate university research grants and contract administration, including the automatic sending of emails for reporting and compliance purposes. These systems are described as “robotic bureaucracy.” The rise of regulations and their contribution to administrative burden on university research have led university administrators to increasingly rely on robotic bureaucracy to handle compliance. This article draws on the administrative burden, behavioral public administration, and electronic communications and management literatures, which are increasingly focused on the psychological and cognitive bases of behavior. These literatures suggest that the assumptions behind robotic bureaucracy ignore the extent to which these systems shift the burden of compliance from administrators to researchers. 相似文献
618.
Steven van den Oord Niels Vanlaer Hugo Marynissen Bert Brugghemans Jan Van Roey Sascha Albers Bart Cambré Patrick Kenis 《Public administration review》2020,80(5):880-894
In this article, the authors describe and illustrate what they call a “network of networks” perspective and map the development of a lead network for the Antwerp Port Authority that governed organizations and networks in the port community before and during the COVID-19 pandemic. They find that setting a collective focus and selective integration are crucial in the creation and reproduction of an effective system to adequately deal with a wicked problem like the COVID-19 pandemic. The findings on crisis management and network governance are used to engage practitioners and public policy planners to revisit the current design and governance of organizational networks within organizational fields that have been hit by the COVID-19 pandemic. 相似文献
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620.
Jan Johnston 《Family Court Review》2012,50(4):543-544