Reviving and revising a termination model

Little research has been reported on the termination of public programs since a prolific period in the late 1970s. The rich conceptualizations from the literature remain largely untested due to research difficulties and to a well-articulated position that terminations (unlike other policy process stages) are the result of luck and consequently unproductive for scientific examination. An investigation of the seventy year long death struggle at the National Hansens Disease Center (formerly the National Leprosarium) verifies that patterns do exist and that deLeon's 1978 termination model, slightly updated, provides a good basis for continuing termination research.     

Revising Our Expectations of Local Government

Significant reform of local government in Victoria has led the way nationally and arguably gone beyond the comparative New Zealand and English experiences. Since the reforms were introduced and elected councillors were returned during 1996 and 1997, there has been an adjustment of roles and responsibilities with varying degrees of acceptance. Reviewing the Victorian experience leads to exploration of the potential within local government to define a strong strategic development role based on larger units of economic influence. This will require continuing cultural change within organisations and a wider focus of responsibility for elected members to rise above the 'pot hole' mentality. Regional Australia will be especially poorly served if this challenge is not taken up. This article reviews the progress of compulsory competitive tendering in Victoria by using a case study of the experience in Ballarat.     

Improving data utilization: the case-wise alternative

Both research and practical experience suggest that alternative forms of data analysis and presentation may affect their use in the policy arena. The variable-wise alternative produces estimates of population parameters through conventional statistical techniques. The case-wise alternative defines and identifies qualitatively distinct types of cases through techniques of numerical taxonomy. In the experiment reported here, variable-wise and case-wise presentations of Census data on poverty were used to compare the effects of the alternatives on policy makers in a priority-setting task. The results show that the case-wise alternative can improve utilization, assimilation, recall, and recognition of the data. Under the circumstances examined here, the case-wise alternative is a practical means of increasing the return on the public's investment in data resources to improve policy decisions.     

Administrative Review in a System of Conflicting Values

An issue of continuing debate in the legal and social science literature is how best to control and validate the exercise of essentially legislative powers by administrative agencies. This study examines one mechanism of control, administrative de novo review of agency decisionmaking. It explores how this device functions in immigration bail administration, a system where there is a broad and vague delegation of detention and bail powers to government oficials in an area of law where there is no set of preferences as to how conflicting policy claims are to be weighed in decisionmaking. The study shows a system in turmoil. The de novo review body–the immigration court-frequently and substantially modifies the Immigration Service's initial bail decisions. Because there is no agreement on the norms to guide decisionmaking, these changes have little effect on ongoing agency activity and policies. Pronounced interagency conflict and extreme decisional disparity persist given limited institutional and political arrangements for dealing with this dissensus. The study explores in detail the institutional cultures and conflicting legal and social values that shape the practice and patterns of de novo review in this field of law and discusses the implications of such conflict for the full functioning of this external review device.     

Embryonic discourse: abortion, stem cells and cloning

This Article interprets the debate about abortion and the debate about embryonic research and therapeutic cloning as aspects of a larger history of ideas. The Article suggests that embryos increasingly stand for different truths in discourse about abortion on the one-hand and about embryonic stem cell research and therapeutic cloning on the other. More specifically, the Article suggests that the contemporary debate about the meaning of the embryo in the context both of abortion and of embryonic research bespeaks a widespread transformation in Western, and especially American, society during the last three or four decades. At base, that transformation involves displacement of an understanding of personhood, particularly in domestic settings that depended on the submersion of individualism with an understanding of personhood that values autonomous individuality and that envisions community as the consequence of individuals' distinct choices rather than as a pre-existing, hierarchically structured whole.     

A simple DNA extraction method for marijuana samples used in amplified fragment length polymorphism (AFLP) analysis

As a first step in developing a molecular method for the individualization of marijuana samples, we evaluated a plant DNA extraction kit. The QIAGEN plant DNeasy method uses a spin column format for recovery of DNA and is effective for obtaining high molecular weight DNA from leaf, flower (bud), and seed samples of marijuana. The average DNA yield was 125-500 ng per 100 milligrams of fresh plant tissue. The recovered DNA was of polymerase chain reaction (PCR) quality as measured by the ability to generate reproducible amplified fragment length polymorphism (AFLP) profiles. AFLP is a technique used to create a DNA profile for plant varieties and is being applied to marijuana samples by the authors to link growers and distributors of clonal material. The QIAGEN plant DNeasy method was simple, efficient, and reproducible for processing small quantities of marijuana into DNA.     

New developments in SPME, Part 1: The use of vapor-phase deprotonation and on-fiber derivatization with alkylchloroformates in the analysis of preparations containing amphetamines

Due to their high polarity and low vapor pressure, most amine salts of amphetamine-type drugs are not directly amenable to headspace recovery using solid-phase microextraction (SPME). Described in this article is a simple vapor-phase procedure for the conversion of solid drug salt samples into their free bases by the use of triethylamine. This process can be conducted simultaneously with headspace SPME, the outcome being that solid drug salts can be sampled directly for GC-MS without the need for dissolution and chemical processing. Potential applications for this methodology include the noninvasive recovery of drug traces from objects such as banknotes and garments. This new process for recovery of amphetamine-type drugs has been combined with on-fiber derivatization using alkylchloroformates. This extra step was included to improve the chromatographic performance of analytes and allow for the resolution of drug enantiomers.     

Treating impulsivity, irritability, and aggression of antisocial personality disorder with quetiapine

There are few effective treatments of antisocial personality disorder (APD). Preliminary work suggests that the atypical antipsychotic quetiapine can decrease irritability, impulsivity, and aggressiveness. Data were collected from 4 patients with APD who were referred to a maximum-security inpatient psychiatric facility for pretrial evaluation and were treated with quetiapine. Quetiapine was effective in these patients as was indicated by a decrease in symptoms such as impulsivity, hostility, aggressiveness, irritability, and rage reactions. Typical dosage was 600 to 800 mg per day. Patients attributed their willingness to comply with quetiapine treatment to both the effectiveness of the drug and its favorable adverse-event profile. Quetiapine was successfully combined with mood stabilizers, particularly gabapentin, in patients with prominent affective instability. Quetiapine has demonstrated efficacy in aggression, impulsivity, and irritability and has proved to be an effective medication in these patients with APD. In addition, its favorable adverse-event profile makes patients willing to comply.