The Use of Race and Ethnicity in Medicine: Lessons from the African-American Heart Failure Trial

Race or ethnic identity, despite its imprecise categorization, is a useful means of identifying population differences in mechanisms of disease and treatment effects. Therefore, race and other arbitrary demographic and physiological variables have appropriately served as a helpful guide to clinical management and to clinical trial participation. The African-American Heart Failure Trial was carried out in African-Americans with heart failure because prior data had demonstrated a uniquely favorable effect in this subpopulation of the drug combination in BiDil. The remarkable effect of the drug in reducing mortality in this study has illuminated an important new mechanism of therapy for heart failure. Application of these findings need not be confined to the population studied, but the observation highlights the need for more precise ways to identify individual responsiveness to therapy.     

Strength and growth in a plantation economy

Conclusion Fogel and Engerman's self-conscious application of economic theory to historical data is extremely useful in clarifying the market relationships operative in the antebellum Southern economy. What is missing in their study is an appreciation of the explanatory limits of the theory they have employed. They have paid a high price in attempting to stretch the capabilities of neoclassical theory into domains beyond its scope. In particular this takes the form of an implicit assumption that if market efficiency is attained, modernization is within reach. There is, on the contrary, no necessary correlation between efficiency defined in this market sense, and long-term strength, growth, or prosperity. Precisely because of the means employed within the plantation economy to achieve viability, there are serious questions which can be raised with respect to both the longevity of the slave system and the consistency of that system with development, and hence an increasing standard of living for its population. In analyzing the internal mechanism by which the slave system worked, Fogel and Engerman interjected issues for which they offered neither testable hypotheses nor employed the relevant methodological framework.     

The debate on World Dynamics: A response to Nordhaus

In a recent paper published in the Economic Journal, Professor William D. Nordhaus of Yale University reviewed World Dynamics by Jay W. Forrester. In his criticism, Nordhaus signals three serious problems and several additional questionable assumptions of sufficient importance to undermine the usefulness of Forrester's book. However, a careful examination of his analysis shows that each point made by Nordhaus rests on a misunderstanding of World Dynamics, a misuse of empirical data, or an inability to analyze properly the dynamic behavior of the model by static equilibrium methods.The three serious problems raised by Nordhaus concern the assumptions that connect industrialization to net birth rates in World Dynamics, the representation of technology and production within the world model, and the impact of prices on global resource use. The analysis presented here refutes the Nordhaus arguments and shows that World Dynamics is consistent with his references to real-world data on population, production, and capital accumulation.This paper is a response to William D. Nordhaus, World Dynamics: Measurement Without Data, published in the Economic Journal, Royal Economic Society, December 1973. An earlier, unpublished, version of the Nordhaus paper, bearing the same title, was widely circulated hand-tohand within the United States, Canada, and Europe. A response to the original Nordhaus paper (System Dynamics Group Memorandum D-1736-4) was written in February 1973 and is available from Jay W. Forrester, Alfred P. Sloan School of Management, Massachusetts Institute of Technology, Cambridge, Mass. 02139. The present paper, a revised version of the earlier response, deals with several new or modified arguments contained in the Economic Journal article by Nordhaus.     

Does ink age inside of a pen cartridge?

In questioned document examination and ink dating, it has been assumed that the ink inside of a pen cartridge does not begin aging until the ink is dispensed onto paper. Positive ion laser desorption (LD) mass spectra were obtained of ink-on-paper samples containing methyl violet, from new and old pens. Mass spectral studies with methyl violet have established the mechanism for how the dye degrades over time, and have provided structural information concerning the dye's degradation products. This information was used as an indication of the relative age of ink on paper. The LD mass spectrum of the ink from a new pen was indicative of "new" ink, whereas the spectra of the ink found in some older pens may appear to be either new or old. The ink from most of the old pens studied appears not to have aged, supporting the common assumption, whereas other ink samples produced "aged" ink spectra, suggesting otherwise.     

White collar crimes and casino gambling: looking for empirical links to forgery,embezzlement, and fraud

This study investigates the alleged link between casino gambling and arrests for the commission of the “white collar” crimes of forgery, fraud, and embezzlement. The rapid expansion of casino gaming venues in recent years has been said to have increased the incidence of white collar crimes by casino customers who get themselves in financial trouble by overspending at casinos (given the median age of 47 for casino patrons and that 41% hold white collar jobs). This study investigates this question by using several kinds of data to examine arrest and offender trends, using a follow-up period of up to 10 years to assess long-term impacts. The results indicate that, comparing pre- and post-casino average annual arrests for embezzlement, forgery, and fraud, trends show a general decrease in arrests in casino jurisdictions, although embezzlement arrests rose in Connecticut and in nationwide statistics. An assessment of the reasons offered from interviews with people convicted of embezzlement and fraud are presented to examine the extent to which gambling is a causal factor.

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Success on Their Own Terms: Youths' Perspectives on Successful Foster Care

Foster care is an integral component of the child welfare system. However, little is known about factors germane to conceptualizing successful foster care. This study utilized Concept Mapping (CM) to delineate a conceptual domain for what success in foster care means from the perspective of those most impacted: foster youth. CM couples multi-dimensional scaling with hierarchical cluster analyses to form factors relevant to an area of study. Pictorial representations of the data were generated using the Concept Systems software. Results indicate that youth conceptualize success based on several distinct domains. The final analyses yielded a multi-cluster solution, or Concept Map.