Fatal intoxication involving 2-methyl AP-237

Novel synthetic opioids contribute considerably to the opioid epidemic, especially with the frequent emergence of structurally similar compounds. This case report describes a fatal intoxication involving 2-methyl AP-237. A 54-year-old Caucasian male was found deceased from an apparent drug overdose. A plastic container labeled “2MAP” and a cut straw were found in the decedent's backpack at the scene. A white substance found in the container tested positive for fentanyl by field testing. According to his medical history, the decedent was treated for a drug overdose 3 years prior to his death. With no diagnostic findings at autopsy, the case was submitted for toxicological analysis. An unknown substance was detected in peripheral blood and urine using gas chromatography with nitrogen phosphorous detection (GC-NPD). Further testing was conducted using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) which confirmed the presence of 2-methyl AP-237 and potential metabolites in blood and urine. Quantitation by GC-NPD revealed concentrations of 2-methyl AP-237 in blood and urine at 480 ng/mL and 4200 ng/mL, respectively. The toxicological analysis also identified and quantitated alprazolam in the blood at 55 ng/mL. Additionally, the metabolism of 2-methyl AP-237 was investigated and three hydroxylated metabolites were identified in peripheral blood and urine. Limited literature is available for the detection and quantitation of 2-methyl AP-237 in postmortem specimens. Given the toxicological findings with unremarkable autopsy findings, this case is an example of a fatal intoxication involving 2-methyl AP-237.     

Waking up on another September 12th: implications for intelligence reform

Abstract

After 9/11 the US Government tried to ‘fix’ intelligence by adopting the Intelligence Reform and Terrorism Prevention Act (IRTPA). Resources increased and, to varying degrees, performance improved – particularly in counterterrorism. This article, however, argues that the constellation of Intelligence Community authorities and organizations, either created or left in place by the IRTPA, coupled with the challenges of a complex security environment, leaves us ill-prepared to deal with the Country’s twenty-first century intelligence requirements. Should that critique prove accurate, and should future intelligence failure(s) be judged strategically and politically unacceptable, the second half of the article provides a framework for revising the IRTPA; the proposals substantially increase the authority of the head of the Intelligence Community, consolidate structures, and create centers of analytic critical mass necessary to meet the knowledge requirements for both regional and transnational security issues. Reflecting the Intelligence Community’s long standing tradition of questioning assumptions, the article is meant to foster reflection and debate about whether the Intelligence Community is postured to meet the needs of the Country, and if not, what needs to change.     

Just Relations: The Story of Mary Bennett's Crusade for Aboriginal Rights

Just Relations: The Story of Mary Bennett's Crusade for Aboriginal Rights. By Alison Holland (Perth: UWA Publishing, 2015), pp. xv + 453. AU$45.00 (pb).     

Procedural Justice,Outcome Favorability and Emotion

This study investigated the effects of procedural justice on discrete emotional responses. Based upon the cognitive appraisal model of emotion, it was argued that the experience of procedural justice (or injustice) allows individuals to derive meaning from favorable and unfavorable allocation decisions. Thus, procedural justice works with outcome favorability to produce a variety of emotional states. These ideas were tested in a laboratory experiment. As predicted, two happiness-related emotions (happiness and joy) and a sadness-related emotion (disappointment) showed only a main effect for outcome favorability. Two anger-related emotions (anger and frustration) were highest when an unfavorable outcome occurred because of an unfair procedure. Higher levels of guilt and anxiety were reported when an unfair procedure resulted in a favorable outcome. Contrary to predictions, a third happiness-related emotion (pride) showed only a main effect for outcome favorability.     

Judicial Interaction on the Latham Court: A Quantitative Study of Voting Patterns on the High Court 1935-1950

This article examines voting patterns in two sub-periods of the Latham Court (1935-1940 and 1940-1950), where voting is defined as a decision (and associated judgements) by the Justices participating in the disposition of a particular case. There are two main findings. First, from 1935 to 1940 there was a clear four-Justice core consisting of Justices Sir George Rich, Sir Owen Dixon, Herbert Vere Evatt and Sir Edward McTiernan. Over this period, both Chief Justice Sir John Latham and Justice Sir Hayden Starke were outside the core. Second, with the retirement of Justice Evatt, and appointment of Justice Sir Dudley Williams in 1940, the decision-making structure of the Court changed. From 1940 to 1950 there was a loose five-Justice core consisting of Chief Justice Latham, Justices Rich, Dixon, McTiernan and Williams with Justice Starke on the outside. The article argues that observed voting patterns can be explained in terms of personal relationships and ideological differences between the Justices.     

Explicit Narcotization: U.S. Policy Toward Colombia During the Samper Administration

Suspecting that his electoral campaign had received contributions from the Cali drug cartel, the U.S. government considered Colombian president Ernesto Samper (1994–98) an enemy in the drug war. U.S. antidrug policy accordingly targeted not just illicit crop cultivation, traffickers, and money laundering but also the democratically elected president himself. In many ways, U.S. policy became obsessed with bringing down Samper, an "explicit narcotization" that had severe consequences for the two countries' relationship. This case study analyzes the often complex interactions between dominant and subordinate states, especially when the dominant state's involvement in the subordinate state is driven by domestic political concerns.     

Taiwan's Strategic Options and the US

This article assesses Taiwan's strategic options in relation to the US. From Taipei's perspective, the first strategic option is to maintain the interest of the US and this is largely done by emphasizing the threat posed by a rising China. The second strategic option relates to gaining more support from the US through highlighting the island republic's democratic credentials. Importantly, limitations exist in Taiwan's strategic options in part because they are subject to positive responses from the US as well as reactions from China. For Taipei, a middle power, the key therefore is achieving an optimal mix of strategies while overcoming any deficiencies in order to enhance its national security.     

Violent Victimization and Perpetration: Joint and Distinctive Implications for Adolescent Development

To date few reports have provided direct comparison of psychosocial vulnerability and resources among youth with victimization and perpetration histories. Within a racially diverse, high-risk adolescent sample (n = 849), this study undertakes MANCOVA tests on a multidimensional set of risk and protective factors contrasting youth with histories of 1) neither violent victimization nor perpetration, 2) victimization only , 3) both perpetration only, and 4) both victimization and perpetration. All three violence-affected groups reported elevated risk and diminished protection, with perpetrating victims demonstrating the greatest psychosocial impairment. Detailed contrasts among the youth group profiles provide insights regarding overlapping and distinct developmental etiologies and implications for preventive and remedial intervention.     

Finding a Safer Harbor: Mandating Health Care Clinics to Intervene in Child Sex Trafficking by Amending the Safe Harbor Act

When it comes to child sex trafficking, health care clinics have become spaces of duality. While these facilities provide medical care to child victims, many argue that this facilitates traffickers in concealing evidence of child sex trafficking. This Note proposes an amendment to New York's Safe Harbor Act and various sections of the Social Services Law to cure legislative ambiguity with respect to health care clinics. The amendment will mandate that all state‐run health care clinics implement a uniform process, utilizing mental health professionals and a standardized interview process, to identify and report instances of potential child sex trafficking.