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11.
Shane Darke Ph.D. Johan Duflou M.Med.Path. F.R.C.P.A. Michelle Torok B.Soc.Sc. 《Journal of forensic sciences》2009,54(2):490-494
Abstract: To determine the prevalence and circumstances of psychoactive substances amongst nonoverdose completed suicide, 1436 consecutive cases autopsied at the NSW Department of Forensic Medicine over the period 1/1/1997–12/31/2006 were analyzed. Substances were detected in 67.2% of cases, and illicit drugs in 20.1%. Alcohol was present in 40.6% of cases. Males were more likely to be positive for alcohol, cannabis, and psychostimulants, and females for pharmaceuticals. Illicits were associated with younger age. Alcohol was most prominent amongst toxicity cases, as were opioids, psychostimulants amongst gunshot cases, and pharmaceuticals amongst drownings. Cases in which drug and alcohol histories were noted were more likely to have a substance detected. Alcohol was more common where a suicide note was left and where relationship problems were involved. Pharmaceuticals were more common where a previous attempt was noted. Licit and illicit substances are strongly associated with suicide, even when the method does not involve drug overdose. 相似文献
12.
Johan Gøtzsche-Astrup 《Journal of Civil Society》2019,15(2):162-177
The literature on the boundary between civil and uncivil society has reached an impasse between approaches that oppose these societies to each other and those that dismiss the boundary altogether. This article suggests an analytical shift to a governmental approach that asks how the relation between civil and uncivil society figures in social practices. The approach is applied to the case of the Danish anti-radicalization discourse which revolves around subjects that cross the boundary. Through a discourse analysis of governmental papers, the author argues that the boundary appears twice. First, as a categorical difference that is simultaneously erected and annulled. This is not a paradox that must be superseded but one which structures a rationality of the governed in Civil Society that a governmental rationality pegs itself to inside an indefinite time. Second, this rationality is only possible through the rejection of violence. This creates a void which serves as an object of the discourse while existing outside the indefinite time of governmentality. 相似文献
13.
Johan C. Van Bruggen Jacob P. Scheele Don F. Westerheijden 《European Journal for Education Law and Policy》1998,2(2):155-163
The authors report on West European trends in follow-up arrangements of national quality assurance procedures. They argue
that external quality assurance ought to adopt a broader conception of quality than is now often the case. Next, the general
public ought to have a guarantee that external quality assurance is valid (through meta-evaluation) and has consequences (through
follow-up arrangements). Follow-up currently is not well developed in many European countries in a formal sense, but is receiving
more attention as external quality assurance is maturing. Finally, the authors link national quality assurance to the European
dimension; an international network could fulfil important functions in making quality assurance transparent and credible
across Europe.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
14.
Issue ownership has been an important concept in the analysis of party competition for several decades. Traditionally, issue ownership has been regarded as a stable phenomenon where parties are advantaged by different political issues. However, several recent studies have reported change in voters’ perceptions of parties’ issue ownership. To investigate the changeability of issue ownership and how it can be altered, this article investigates the impact of parties’ communication attempts through a web-based survey in Sweden. Two major political issues are in focus: employment and healthcare. The results show that parties can indeed improve their ownership by communicating on an issue. Indications were also found that the effects decrease as other parties simultaneously communicate on the same issue, and when those who receive the messages are ideologically distant from the party. However, in several cases results are weak. Many important conditionalities therefore remain to be explored in future studies. 相似文献
15.
16.
Johan Den Hertog 《European Journal of Law and Economics》2003,15(2):111-127
Generally, legislators and courts look upon noncompetition agreements unfavourably. This paper questions the assumptions underlying the traditional theories on noncompetition clauses and advances two theories that have previously not been found in the legal literature. It is argued that noncompetition clauses are used as a device to self-select employees who desire a long-term contract with the firm. Furthermore, employees agree to these clauses to guarantee that the employer will make specific investments in the employment relationship. The noncompetition agreement protects the creation and distribution of the surplus of the employment relationship. Legal restrictions on noncompetition clauses have the danger of decreasing the ex ante value of the employment relationship. The result will be lower investments and lower wages. 相似文献
17.
18.
Lock E Aalberg L Andersson K Dahlén J Cole MD Finnon Y Huizer H Jalava K Kaa E Lopes A Poortman-van der Meer A Sippola E 《Forensic science international》2007,169(1):77-85
This paper is the fifth in a series of six in relation to the development of a harmonised method for the profiling of amphetamine [L. Aalberg, K. Andersson, C. Bertler, H. Borén, M.D. Cole, J. Dahlén, Y. Finnon, H. Huizer, K. Jalava, E. Kaa, E. Lock, A. Lopes, A. Poortman-van der Meer, E. Sippola, Development of a harmonised method for the profiling of amphetamines I. Synthesis of standards and compilation of analytical data, Forensic Sci. Int. 149 (2005) 219-229; L. Aalberg, K. Andersson, C. Bertler, M.D. Cole, Y. Finnon, H. Huizer, K. Jalava, E. Kaa, E. Lock, A. Lopes, A. Poortman-van der Meer, E. Sippola, J. Dahlén, Development of a harmonised method for the profiling of amphetamines II. Stability of impurities in organic solvents, Forensic Sci. Int. 149 (2005) 231-241]. The third paper [K. Andersson, K. Jalava, E. Lock, L. Aalberg, Y. Finnon, H. Huizer, E. Kaa, A. Lopes, A. Poortman-van der Meer, M.D. Cole, J. Dahlén, E. Sippola, Development of a harmonised method for the profiling of amphetamines III. Development of the gas chromatographic method, Forensic Sci. Int., in press] dealt with the optimisation of the gas chromatographic and detection methods whereas the fourth paper [K. Andersson, K. Jalava, E. Lock, Y. Finnon, S. Stevenson, L. Aalberg, H. Huizer, E. Kaa, A. Lopes, A. Poortman-van der Meer, M.D. Cole, J. Dahlén, E. Sippola, Development of a harmonised method for the profiling of amphetamines IV. Optimisation of sample preparation, Forensic Sci. Int., in press] concerned the optimisation of the extraction method prior to GC analysis. This paper is a study of the optimised method in order to determine its stability. Investigations of within and between day variations were carried out in four laboratories. Moreover, variations between laboratories were also determined. Both flame ionisation detector (FID) and MS detection were used. One laboratory studied nitrogen-phosphorous detector (NPD) detection as well. For this task, 12 batches of amphetamine were prepared. Six of them were synthesised via the Leuckart route, three via the nitrostyrene route and three via the reductive amination route [A.M.A. Verweij, Impurities in illicit drug preparations: amphetamine and methamphetamine, Forensic Sci. Rev. 1 (1989) 2-11]. Taking into account all studied target compounds and the average results from four laboratories, the within day variation was around 6% for FID and 5% for MS, the between days variation was around 10% for FID and 8% for MS. For NPD detection, within day variation was 5% and between days variation 9% (only one laboratory). Finally, the inter-laboratory variation was about 12% for FID (four laboratories) and 10% for MS (three laboratories). 相似文献
19.
Kingbäck M Karlsson L Zackrisson AL Carlsson B Josefsson M Bengtsson F Ahlner J Kugelberg FC 《Forensic science international》2012,214(1-3):124-134
Venlafaxine (VEN) is an antidepressant drug mainly metabolized by the cytochrome P450 (CYP) enzyme CYP2D6 to the active metabolite O-desmethylvenlafaxine (ODV). VEN is also metabolized to N-desmetylvenlafaxine (NDV) via CYP3A4. ODV and NDV are further metabolized to N,O-didesmethylvenlafaxine (DDV). VEN is a racemic mixture of the S- and R-enantiomers and these have in vitro displayed different degrees of serotonin and noradrenaline reuptake inhibition. The aim of the study was to investigate if an enantioselective analysis of VEN and its metabolites, in combination with genotyping for CYP2D6, could assist in the interpretation of forensic toxicological results in cases with different causes of deaths. Concentrations of the enantiomers of VEN and metabolites were determined in femoral blood obtained from 56 autopsy cases with different causes of death. The drug analysis was done by liquid chromatography tandem mass spectrometry (LC/MS/MS) and the CYP2D6 genotyping by PCR and pyrosequencing. The mean (median) enantiomeric S/R ratios of VEN, ODV, NDV and DDV were 0.99 (0.91), 2.17 (0.93), 0.92 (0.86) and 1.08 (1.03), respectively. However, a substantial variation in the relationship between the S- and R-enantiomers of VEN and metabolites was evident (S/R ratios ranging from 0.23 to 17.6). In six cases, a low S/R VEN ratio (mean 0.5) was associated with a high S/R ODV ratio (mean 11.9). Genotyping showed that these individuals carried two inactive CYP2D6 genes indicating a poor metabolizer phenotype. From these data we conclude that enantioselective analysis of VEN and ODV can predict if a person is a poor metabolizer genotype/phenotype for CYP2D6. Knowledge of the relationship between the S- and R-enantiomers of this antidepressant drug and its active metabolite is also important since the enantiomers display different pharmacodynamic profiles. 相似文献
20.
Johan Duflou F.R.C.P.A. Bradley McNamara Certificate in Mortuary Practice Robert Cluney Certificate in Mortuary Practice 《Journal of forensic sciences》2014,59(1):224-225
Restoration of autopsy incisions can result in inadvertent needle stick injury to the prosector, which can be difficult to prevent even with the use of personal protective equipment such as Kevlar cut resistant gloves. We present a new technique for closure of autopsy incisions using a commonly available commercial hardware tool, a hole punch with a lever enhanced action, combined with blunt probe sewing, which results in an esthetic and leak‐proof means of restoring cadavers. This technique is especially useful in cases which may pose blood‐borne infection risks to the prosector. 相似文献