Psychostimulant Use and Fatal Stroke in Young Adults

Psychostimulant use is associated with increased stroke risk. To determine the proportion of psychostimulant users among fatal strokes in young adults (15–44 years), all cases were retrieved from the National Coronial Information System (1/1/2009–31/12/2016). A total of 279 cases were identified: hemorrhagic (259), ischemic (8), thrombotic (8), and mycotic (4). Fifty (17.9%) were identified as psychostimulant users. Psychostimulants in blood were detected in 37/45 where toxicology was available, predominantly methamphetamine (32/45). Hemorrhagic strokes in the psychostimulant group were more likely to be intraparenchymal (OR 2.33). Psychostimulant users were less likely to be obese (OR 0.31), but more likely to have a history of tobacco use (OR 2.64). No psychostimulant user had a previous stroke history, was gravid/postpartum, or diagnosed with cerebral vasculitis or endocarditis. The work illustrates the substantial role of psychostimulant use in fatal strokes among young adults. In cases of hemorrhagic stroke among young adults, psychostimulant use should be considered.     

Spontaneous formation of γ-hydroxybutyric acid from γ-butyrolactone in tap water solutions

The spontaneous conversion of γ-butyrolactone (GBL) to γ-hydroxybutyric acid (GHB) in seven different Swedish tap waters was investigated. The waters used in the study were selected to represent the diversity among Swedish tap waters as well as possible, which was enabled by principal component analysis (PCA) of a number of water quality parameters. GBL solutions (5, 25 and 50% v/v) were prepared in each of the tap waters and in deionized water and the formation of GHB was followed over time. The GHB quantifications were made using a CZE method, employing a carrier electrolyte consisting of 25mM benzoic acid, 54mM tris(hydroxymethyl)aminomethane (Tris) and 1.7mM tetradecyltrimethylammonium bromide (TTAB), which was developed as a part of the current study. Data evaluation showed that the formation of GHB was largely dependent on the type of tap water. For example, there was a negative correlation between the kinetics of the GHB formation and the alkalinity of the tap waters (r(2)=0.990). This could be explained by a faster decrease in pH in the waters with low buffering capacity (i.e. low alkalinity), which catalysed the hydrolysis of GBL. Equilibrium was reached after 40-250 days depending on the initial GBL concentration and the type of tap water. The level of the equilibrium appeared to be dependent on the initial GBL concentration and ranged from 26 to 37%. Gained knowledge on the levels of the GHB/GBL equilibrium and the kinetics of the formation of GHB in tap water solutions of GBL, including the influence of the tap water quality, may be useful information for casework with the GHB/GBL problem in focus.     

Clinical Characteristics of Fatal Methamphetamine‐related Stroke: A National Study

The study aimed to determine the clinical characteristics of fatal methamphetamine‐related stroke in Australia, 2009–2015. There were 38 cases, 60.5% male, with a mean age of 40.3 years. In no case was there evidence that this was the first time methamphetamine had been used by the decedent, and 52.6% had known histories of injecting drug use. The stroke was hemorrhagic in 37 of 38 cases. In 21.1% of cases, the stroke was purely parenchymal and, in 18.4%, involved purely the subarachnoid space. A ruptured berry aneurysm was present in 31.6% and in 68.8% of initial subarachnoid hemorrhages. There was evidence of systemic hypertension in 8 of 25 cases in which full autopsy findings were available. With increased use of methamphetamine, there is a high probability of increased hemorrhagic stroke incidence among young people. In cases of fatal hemorrhagic stroke among young cases presenting to autopsy, the possibility of methamphetamine use should be borne in mind.     

Process Management as a Contagious Idea: A Contribution to Røvik's Virus-Inspired Theory

‘Travelling ideas’ denotes the fact that virtually identical management ideas crop up more or less simultaneously in similar organizations. Røvik, who recently launched his ‘virus-inspired theory’ approach, seeks to pinpoint the possibility that the encounter between idea and practice may be lasting, ideas may affect practice, and leaders in organisations may play a more active role than the one often depicted in management fashion theory. This article is a contribution to his virus-inspired theory. It focuses on processes in their pragmatic form, as value-creating flows in organisations. We have studied Process Management (PM) as an idea, and how it has penetrated and flourished in the Swedish Customs Service. We argue that the empirical test in this article supports Røvik's belief that a virus-inspired theory gives a richer picture than the fashion theory. Through our analysis we show that four of our six hypotheses, derived from the virus-inspired theory, are strengthened by the empirical story from the Customs Service.     

Partner similarity for self-reported antisocial behaviour among married,cohabiting and dating couples: the Generation R Study

Abstract

From a criminological perspective, romantic relationships are supposed to decrease the risk of antisocial behaviour (Laub, Nagin, & Sampson, American Sociological Review, 63, 225–238, 1998). However, the effects of these relationships probably depend on the romantic partner's behaviour. In the current study we examined partner similarity for antisocial behaviour in an ethnically heterogeneous community sample of 4135 married, cohabiting and dating couples from Rotterdam, the Netherlands, using self-reports. Spousal correlations were consistently positive for antisocial behaviour but differed in strength according to the type of antisocial behaviour. Associations between spouses remained strong after adjusting for age and educational level depending on the type of antisocial behaviour. In addition, antisocial behaviour was positively associated between partners across marital status and ethnicity, but the strength of this association varied to some extent. Results are discussed in light of the phenotypic assortment, the socialization and the social homogamy hypotheses.     

Gender and Modern Supply Chains in Developing Countries

The rapid spread of modern supply chains in developing countries is profoundly changing the way food is produced and traded. In this article we examine gender issues related to this change. We conceptualise various mechanisms through which women are directly affected, we review existing empirical evidence and add new survey-based evidence. Our results suggest that, although modern supply chains are gendered, their growth is associated with reduced gender inequalities in rural areas. We find that women benefit more and more directly from large-scale estate production and agro-industrial processing, and the creation of employment in these modern agro-industries than from smallholder contract-farming.     

Regulations,Brokers, and Interlinkages: The Institutional Organization of Wholesale Markets in India

There is a vigorous debate on the liberalisation of heavily regulated agricultural markets in India. A crucial institutional characteristic is the role of state regulated brokers in wholesale markets. Relying on data from a unique survey in Uttarakhand, a state in North India, we find that regulations on margins are ineffective as most brokers charge rates that significantly exceed the regulated ones. We also find that a majority of farmers self-select into long-term relationships with brokers. These relationships allow some of the farmers to interlink credit and insurance markets to the agricultural output market. This interlinkage does however not appear to be an instrument for farmer exploitation (as it does not lead to worse inputs, high interest rates, or lower implicit output prices), but is seemingly an extra service by brokers as to establish farmer loyalty to them and thus to ensure future supplies.     

The Institutional Basis of Democratic Accountability

This article offers an institutional approach to accountability in representative democracies. Theorising accountability comprises both settled polities with well-entrenched institutions and unsettled polities with weak or contested institutions, and it is argued that agency theory and formal principal–agent models giving priority to compliance and control usually make assumptions that are unlikely to apply to the latter type of polity. An institutional approach challenges principal–agent assumptions regarding what accountability means and implies, what is involved in demanding, rendering, assessing and responding to accounts and assigning accountability, and how accountability institutions work and change. Accountability is related to fundamental issues in democratic politics and the paper treats distributions of information, normative standards of assessment, authority and power relations as endogenous to democratic politics. The paper also holds that institutions affect actors’ identities and roles through socialisation, internalisation and habitualisation, as well as through external incentives. An aspiration is to take a modest step towards understanding areas of application for competing approaches to democratic accountability.     

Recruitment and Expertise in the European Commission

The article examines the changes in the European Commission’s recruitment practices from its creation in the 1950s until today. Based on the insight that recruitment shapes the role of professional experts in public bureaucracies, the article traces the emphasis on specialist skills and qualifications in the Commission’s recruitment competitions (the concours) over time. It finds that the selection of policy staff to the Commission has become more generalist since the 1960s, a surprising finding given that the organisation is often regarded as a ‘technocracy’ dominated by experts. The article attributes this development to the multinational character of the administration, as the need to integrate citizens from new member states has prompted the Commission to rely on one-size-fits-all recruitment tests. It also discusses whether the declining emphasis on specialist knowledge in staff selection can be seen as part of a broader trend towards a more generalist Commission, where officials are required to change jobs frequently and where expert functions are outsourced to other bodies.