Drugs in postmortem adipose tissues: evidence of antemortem deposition

INTRODUCTION: Drug concentration measured in postmortem adipose tissue may or may not reflect antemortem concentration. To examine the possibility of whether the presence of basic drugs in adipose tissue is the result of postmortem change, we examined: tissues with and without livor mortis, concentration gradients within the adipose layer, and the stability of drug concentrations during the postmortem period. CASE REPORTS: Five drug-related deaths with case histories and analytical data are presented. Adipose tissues with and without livor mortis from the thigh area of the same decedent were analyzed for cocaine. The cocaine concentration of the tissue exhibiting 4+ livor was equivalent to the concentration observed in tissue without livor. Analyses of cross sections of adipose tissues containing cocaine and methamphetamine disclosed that drug concentrations were equally distributed throughout the layer, from just beneath the dermis to directly above the muscle. When morphine and temazepam concentrations were measured in adipose tissues collected from similar sites, but at different times, from the same cadaver, they remained essentially the same over 3 days (approximately 80 h). CONCLUSIONS: Since concentrations were the same in areas with and without livor mortis, the possibility of redistribution into adipose from blood or vascular channels is eliminated. The absence of a concentration gradient within the adipose layer rules out diffusion or permeation from muscle into the adipose layer, and the failure of morphine or temazepam concentration to change over time indicates that drugs in the adipose tissue are stable during the postmortem interval. Our findings support the notion that drugs identified in postmortem adipose tissue are there because of antemortem deposition and not because of any postmortem change or event.     

Comparison of urine to sweat patch test results in court ordered testing

A former cocaine and methamphetamine abuser was continuously monitored with both sweat patch and urine testing for approximately 6 months. Thirteen sweat patches were applied and collected, five were positive for cocaine and/or methamphetamine, but all the urine specimens collected were negative at the analytical cut-off levels. The high incidence of false positive sweat patch tests in relation to the sensitivity, specificity, and efficiency of the sweat patch assay is discussed. Possible mechanisms, which can lead to false positive results, are presented. The results of our study raise further questions about the preferential use of the sweat patch in detecting new episodes of drug use in formerly chronic drug users.     

Assessing Data Completeness,Quality, and Representativeness of Justifiable Homicides in the FBI’s Supplementary Homicide Reports: A Research Note

Journal of Quantitative Criminology - The most widely used data set for studying police homicides—the Supplementary Homicide Reports (SHR) kept by the Federal Bureau of Investigation—is...     

Strengthening the Connection Between Acquired Brain Injury (ABI) and Family Violence: The Importance of Ongoing Monitoring,Research and Inclusive Terminology

Family violence (FV) harms communities worldwide so FV prevention strategies and effective responses are urgently needed. This article reports on FV apparent in a study which explored the experiences of people with both ABI and justice system encounters in Victoria, Australia. One hundred interviews and one focus group consulted people with ABI, their families and carers, and various stakeholder groups in the Victorian justice system in Australia. Qualitative content analysis determined dominant themes and sub-themes and the less common themes. Inductive interpretive content analysis identified themes commonly found in previous published research and themes that appeared unique to, or unanticipated in, our data, such as the FV theme upon which this article focuses. Our findings reveal that FV has adversely affected many people with ABI who came into contact with Victoria’s justice system. Further, as ABI and FV often co-occur with substance abuse, mental health problems, socio-economic and many other significant disadvantages, for some FV perpetrators with an ABI, their ABI symptoms and characteristic co-morbidities may be a mitigating factor in their offending. The connection between ABI and family violence emerged as a troubling research theme. Indeed, the impact of FV on too many of our participants with an ABI compels us to call for further related research and secondary prevention programs targeted at FV victims, and offenders, living with ABI. An intersectional understanding of family violence and TBI/ABI in social ecological contexts is required to better understand brain injury at both individual and population levels.

     

Guilty Plea Decisions: Moving Beyond the Autonomy Myth

When a defendant pleads guilty to a criminal charge against them their conviction may be justified on the basis of autonomy rather than accuracy. In this context, autonomy can make the difference between a legitimate conviction and the breach of fundamental rights. However, autonomy in this context is not clearly defined. This article argues, based on philosophical conceptions of autonomy and empirical realities, that true autonomy is an ideal rather than a practical reality. It considers the level of autonomy necessary to legitimise a criminal conviction via plea, and suggests that current conceptions of autonomy are inadequate since they rely on a formalistic autonomy ‘myth’, presuming autonomy in the absence of threats. An analysis drawing on original empirical data from two studies demonstrates how autonomy may be being depleted to unacceptable levels in the current system. The article concludes by presenting reform proposals.     

Analytical thinking,prosocial voting,and intergroup competition: experimental evidence from China

Public Choice - We investigate whether and how analytical thinking affects Muslims’ prosocial voting towards in-group (fellow Muslims) and out-group (Han Chinese) members. We conduct an...     

Blame,Responsibility, and the Tea Party in the 2010 Midterm Elections

There is a general consensus both in the news media and scholarly research that 2010 was a highly nationalized election year. Reports have indicated that anti-Obama sentiment, the Democrats’ legislative agenda, the economy, and the Tea Party were all factors contributing to Democratic losses in the congressional elections. In this paper, we use data from 2010 Cooperative Congressional Election Study to examine the individual-level dynamics that contributed to the heightened nationalization of the 2010 congressional elections. Our analysis shows that Tea Party support and the attribution of blame and responsibility by voters are essential to understanding the 2010 election outcome, beyond what we would expect from a simple referendum model of midterm elections. Not surprisingly, Tea Party supporters blamed Democrats for the state of national affairs, disapproved of the Democrats’ policy agenda, and overwhelmingly supported Republican candidates in the congressional elections. However, our analysis shows that not all voters who supported Republican candidates were driven by high levels of opposition to President Obama and the Democrats. Another key group of voters blamed both Democrats and Republicans for the nation’s problems but ultimately held Democrats responsible in the voting booth by supporting Republican congressional candidates.     

Preliminary evaluation of the use of pharmacological treatment with convicted sexual offenders experiencing high levels of sexual preoccupation,hypersexuality and/or sexual compulsivity

The current study presents the preliminary evaluation of the impact of pharmacological treatment (Selective Serotonin Reuptake Inhibitors and anti-androgens) on hypersexuality, sexual preoccupation and sexual compulsivity. The participant pool comprised 64 convicted UK sexual offenders who had been voluntarily referred for pharmacological treatment to reduce their hypersexual arousal, 51 of whom agreed to take the medication (with a further five individuals on hold or under assessment at the time of data extraction). The preliminary findings were very encouraging; analysis on measures assessing sexual preoccupation, hypersexuality and sexual compulsivity indicated a significant reduction between pre- and post-medication, across both types of medication. Limitations of the current research are discussed.     

Towards a theory of cultural evaluation

From which evaluative base should we develop public policies designed to promote wellbeing among different cultural groups in different circumstances? This article attempts to advance an objective, universal theory of cultural evaluation grounded in a eudaemonistic account of human wellbeing. The approach evaluates cultures on the success with which they enable societies to promote the wellbeing of individuals through provision of needs and capabilities within their given, determinate circumstances. This provides the basis for a normative functionalism capable of identifying and explaining cultural deficits.