Disopyramide and Mianserin Intoxication: A Unique Fatal Case – Review of the Literature

Lethal occurrence is exceptional after disopyramide or mianserin poisoning. A case of intentional lethal intoxication with these drugs was reported, as well as a review of the literature. Pre‐ and postmortem blood concentrations of disopyramide or mianserin were assessed in a woman who died from acute cardiac failure after ingestion. The premortem blood concentration of disopyramide alone was considered lethal, and a toxic premortem concentration of mianserin was observed that may have increased cardiovascular failure induced by disopyramide because the metabolism of both drugs is mediated via cytochrome P450. Moreover, it was shown that the postmortem redistribution of disopyramide was limited, as pre‐ and postmortem concentrations were 48 and 65 mg/L, respectively. As regards mianserin, redistribution was observed after death with pre‐ and portmortem concentrations at 0.23 and 0.79 mg/L, respectively. This case illustrates that if postmortem blood concentration of disopyramide is known, the premortem concentration can be deduced.     

Privacy notices versus informational self-determination: Minding the gap

Privacy notices are instruments that intend to inform individuals of the processing of their personal data, their rights as data subjects, as well as any other information required by data protection or privacy laws. The goal of this paper is to clarify the current discourse regarding the (in)utility of privacy notices, particularly in the context of online transactions. The perspective is a European one, meaning that the analysis shall be geared towards the European Data protection framework, particularly the European Data Protection Directive. The paper discusses the role that privacy notices play under the European data protection framework today, summarizes the main critiques regarding the use of privacy notices in practice and develops a number of recommendations.     

At the end of a fairy tale: romantic relationships in female juvenile offenders

This study explores romantic relationships among female juvenile offenders. The entire female population of a juvenile detention center at the moment of the study participated in a semi-structured interview. Using a semi-structured interview, the girls answered questions on four main topics: (a) available dating partners before entering the detention center; (b) dating partner preferences; (c) intimate relationships within the center; and (d) romantic relationships. A 34-item scale was also used to assess their dating partner preferences. Most girls depicted dysfunctional families and a reduced range of dating options, many involving male offenders. Most participants had also been precocious in their relationships and experienced victimization at the hands of their intimate partners. Implications to prevent female involvement with criminal and violent men are discussed.     

Euvoluntariness and just market exchange: moral dilemmas from Locke’s Venditio

It is a maxim of Public Choice that voluntary exchanges should not be interfered with by the state. But what makes a voluntary market exchange truly voluntary? We suggest, contra much of the economics literature, that voluntary exchange requires consent uncoerced by threats of harm, but that this is not sufficient. In particular, a person pressured to exchange by the dire consequences of failing to exchange—e.g., dying of thirst or hunger—is still coerced, and coerced exchange cannot be voluntary. The weaker party’s desperation gives the other party unconscionable bargaining power. We argue for a distinction, based on a neologism: in the case of coercion by circumstance but not by threat, exchange is still voluntary in the conventional sense, but it is not euvoluntary (i.e., truly voluntary). We will argue that all euvoluntary exchanges are just, while non-euvoluntary exchanges may or may not be unjust; that in competitive markets all exchanges are just, even those that are not euvoluntary, while in bilateral monopolies some exchanges are neither euvoluntary nor just. We will propose a mental device, the “fictitious negotiation”, to determine the just price in non-euvoluntary market exchanges. A primitive version of these ideas can be found in a little known monograph by John Locke, which we will analyze in detail.     

On the efficiency of equilibria in a legislative bargaining model with particularistic and collective goods

Voter initiatives are important for policy making in many countries. While much research shows that the initiative process affects policy choices, almost no evidence explains how the initiative process affects policy. Initiatives might change policy directly through voters approving laws that override the legislature; or the initiative process may change policy indirectly by providing a threat that induces the legislature to change policy. This article develops an empirical strategy to measure the direct and indirect effects of the initiative based on the idea that direct effects can be inferred from states that actually pass initiatives while indirect effects can be inferred from states where the initiative is available but not used. Evidence from 50 states on nine separate issues suggests that both direct and indirect effects are important, but the direct effect is several times larger than the threat effect.     

Public affairs in Hungary today: summarized through the eyes of a practitioner

This is not an academic overview on public affairs in Hungary, as this has already been written very well by many others. I would like to share my views and experience as a practitioner and give a quick insight into how public affairs is regarded in my country and how it developed after the change of the political system in Central and Eastern Europe. I will refrain from explaining what public relations or public affairs entails as I think this is unnecessary for anyone reading this. Copyright © 2014 John Wiley & Sons, Ltd.     

Metagovernance and Control of Multi-level Governance Frameworks: The Case of the EU Structural Funds Financial Execution

Using as an empirical base the 2006–08 reform of the European Union Structural Funds financial execution, this paper explores control mechanisms of multi-level governance frameworks. The empirical evidence provides a representative case of initial metagovernance deficit and the subsequent, relatively successful, institutional response reinforcing metagovernance. The purpose is to clarify the conceptual dimensions of metagovernance, setting it in a categorical scheme that identifies forms of exercise of political power: government, governance and multi-level governance. Specifically, the paper argues for a conceptualization of metagovernance that highlights a sense of sovereignty by which governmental entities vested with legal legitimacy advance public interests.     

Population data of five STRs in three regions from Portugal

Allele and haplotype frequencies of five chromosome STR loci (CD4, TPO, FES, TH01 and VWA) were determined for unrelated males throughout Portugal. This report presents STR data for three separate regions of Portugal, being the first time that data on the south of the country is presented. This study reveals that the three regions from Portugal are not genetically homogeneous. The north of Portugal presents significant differences in the CD4 locus, when compared with the other two populations. When compared with Madeira and A?ores, the three regions show a different behavior at TPO and VWA loci.     

Real-time PCR designs to estimate nuclear and mitochondrial DNA copy number in forensic and ancient DNA studies

We explore different designs to estimate both nuclear and mitochondrial human DNA (mtDNA) content based on the detection of the 5' nuclease activity of the Taq DNA polymerase using fluorogenic probes and a real-time quantitative PCR detection system. Human mtDNA quantification was accomplished by monitoring the real-time progress of the PCR-amplification of two different fragment sizes (113 and 287 bp) within the hypervariable region I (HV1) of the mtDNA control region, using two fluorogenic probes to specifically determine the mtDNA copy of each fragment size category. This mtDNA real-time PCR design has been used to assess the mtDNA preservation (copy number and degradation state) of DNA samples retrieved from 500 to 1500 years old human remains that showed low copy number and highly degraded mtDNA. The quantification of nuclear DNA was achieved by real-time PCR of a segment of the X-Y homologous amelogenin (AMG) gene that allowed the simultaneous estimation of a Y-specific fragment (AMGY: 112 bp) and a X-specific fragment (AMGX: 106 bp) making possible not only haploid or diploid DNA quantitation but also sex determination. The AMG real-time PCR design has been used to quantify a set of 57 DNA samples from 4-5 years old forensic bone remains with improved sensitivity compared with the slot-blot hybridization method. The potential utility of this technology to improve the quality of some PCR-based forensic and ancient DNA studies (microsatellite typing and mtDNA sequencing) is discussed.