Immunofixation of complement component C3 phenotypes in bloodstains after cellulose acetate electrophoresis

The determination of the polymorphic C3 phenotypes was accomplished by electrophoresis on cellulose acetate followed by immunofixation. The three common phenotypes resulting from the two common codominant alleles C3S and C3F were clearly distinguishable in blood and bloodstain samples. Storage and degradation of C3 in blood samples as well as the stability of C3 in dried bloodstains is discussed.     

Building a U.S.-Soviet working relationship

Conclusion The crucial determinant of U.S. and Soviet security, and the security of the world, will not depend on technological development, breakthroughs in deterrence theory, or even on agreements the two countries might sign at the summit talks. The future depends on whether the two governments are able to work together.Both the United States and the Soviet Union have developed procedures for solving conflicts with other governments, even former enemies, without hostilities or threats of force. The essential difference between these relationships and the U.S.-Soviet relationship lies not in the degree of difference in cultural heritage or security interests, but in the way the two governments approach their problems—through consultations and dispute resolution procedures, or through conflict and recrimination.The process of interaction is the essence of a working relationship. It means the difference between hostile confrontation and constructive collaboration, between fear and security, between war and peace. The summit meeting provides an opportunity to change the nature of the relationship, to change the focus of U.S.-Soviet interaction from antagonistic bargaining over divisive issues to constructive collaboration on possible solutions and working procedures. Roger Fisher is Williston Professor of Law at Harvard Law School and Director of the Harvard Negotiation Project, 523 Pound Hall, Harvard Law School, Cambridge, Mass. 02138.Scott Brown is Associate Director of the Harvard Negotiation Project.     

A Multilevel Investigation of the Association between School Context and Adolescent Nonphysical Bullying

Although researchers have identified individual-level predictors of nonphysical bullying among children and youth, school-level predictors (i.e., characteristics of the school environment that influence bullying exposure) remain largely unstudied. Using data from a survey of 1,838 students in 21 Boston public high schools, we used multilevel modeling techniques to estimate the level of variation across schools in student reports of nonphysical bully victimization and identify school-level predictors of bullying. We found significant between school variation in youth reports of nonphysical bullying, with estimates ranging from 25-58%. We tested school-level indicators of academic performance, emotional well-being, and school safety. After controlling for individual-level covariates and demographic controls, the percent of students in the school who met with a mental health counselor was significantly associated with bullying (OR = 1.03, 95% CI = 1.01, 1.06). There was no significant association between school-level academic performance and perceptions of school safety on individual reports of bullying. Findings suggest that prevention and intervention programs may benefit from attending to the emotional well-being of students and support the importance of understanding the role of the school environment in shaping student experiences with bullying.     

Incentivizing professionals and patients: a consideration in the context of the United Kingdom and the United States

We are at the beginning of an era in which the pressure to secure the biggest possible "bang" for the health care "buck" is perhaps higher than it ever has been, on both sides of the Atlantic, and within the health policy discourse, incentives, for both professionals and patients, are occupying an increasingly prominent position. In this article, we consider issues related to motivating the professional and the patient to perform targeted actions, drawing on some of the evidence that has thus far been reported on experiences in the United Kingdom and the United States, and we present an admittedly somewhat speculative taxonomy of hypothesized effectiveness for some of the different methods by which each of these two broad types of incentives can be offered. We go on to summarize some of the problems of, and objections to, the use of incentives in health and health care, such as those relating to motivational crowding and gaming, but we conclude by positing that, following appropriate consideration, caution, and methodological and empirical investigation, health-related incentives, at least in some contexts, may contribute positively to the social good.     

Sociodemographic and diagnostic characteristics of homicidal and nonhomicidal sexual offenders

The aims of this study were to compare the prevalence of psychiatric disorders and "psychopathy" in homicidal and nonhomicidal sexual offenders and to investigate the specificity of previous studies on psychiatric morbidity of a sample of sexual murderers. Information from court reports of 166 homicidal and 56 nonhomicidal sex offenders was evaluated using standardized instruments (SCID-II, PCL-R) and classification systems (DSM-IV). Sexual murderers were diagnosed more often with a personality disorder (80.1% vs. 50%; p < 0.001), especially schizoid personality disorder (16.3% vs. 5.4%; p < 0.05), as well as with sexual sadism (36.7% vs. 8.9%; p < 0.001) and sexual dysfunctions (21.7% vs. 7.1%; p < 0.05). Additionally, they had more often used alcohol during the offense (63.2% vs. 41%; p < 0.05). The results indicate that sexual murderers have more and a greater variety of psychiatric disorders when compared to nonhomicidal sex offenders.     

Relationship of School Context to Rural Youth’s Educational Achievement and Aspirations

Though the poverty encountered by many rural youth encompasses numerous developmental challenges and substantially increases the chances for educational problems, the school context is central to promoting and constraining their development. Therefore, the purpose of this study was to investigate the relationship of school characteristics and schooling experiences to the educational achievement and aspirations of youth from high-poverty rural communities. Differences in the relationship of school characteristics and schooling experiences to the educational outcomes of students from high- versus low-poverty rural communities were also examined. Participants included 6,247 high school students from 43 low-poverty and 21 high-poverty rural communities. Approximately 51.7% of participants were female and the sample was racially/ethnically diverse (66.4% White, 9.2% African American, 8.1% Hispanic/Latino(a), 4.4% Native American, and 11.8% Multiracial). After controlling for student and family background, school characteristics (e.g., lower student–teacher ratio) were predictive of achievement for rural youth from high-poverty communities. Schooling experiences (e.g., positive perceptions of their ability, a sense of school valuing and belonging, and preparation for postsecondary education) were predictive of educational achievement and aspirations for rural youth from high- and low-poverty communities. Overall, the study highlights unique ways schools can positively shape the educational outcomes for rural youth despite community poverty.     

“IF I COULD TELL THE JUDGE SOMETHING ABOUT ATTACHMENT. . . .” PERSPECTIVES ON ATTACHMENT THEORY IN THE FAMILY LAW COURTROOM

This article gathers diverse attachment specialists in a far reaching conversation about the utility of attachment assessment and theory for complex family law decision making, and reflections on the thorny question, “If I were the judge . . .?” Inge Bretherton, Professor Emerita, Developmental Psychology at Wisconsin University, is one of a few attachment researchers in the Bowlby/Ainsworth tradition to have completed studies in the divorce field. Seligman, a psychoanalyst and clinical psychologist, Solomon, a clinical psychologist and researcher, and Crowell, professor of psychiatry and psychology, take on some large controversies, and offer well over 100 years combined experience of applying attachment knowledge in complex family matters.     

The CSI effect and the Canadian and the Australian Jury

Television shows, such as CBS's CSI and its spin-offs CSI: Miami; CSI: Las Vegas; and CSI: New York, have sparked the imagination of thousands of viewers who want to become forensic scientists. The shows' fictional portrayals of crime scene investigations have prompted fears that jurors will demand DNA and other forensic evidence before they will convict, and have unrealistic expectations of that evidence. This has been dubbed the "CSI effect." This phenomenon was explored using results from a Canadian study based on 605 surveys of Canadian college students who would be considered jury-eligible and Australian quantitative and qualitative findings from a study that surveyed and interviewed real posttrial jurors. Information about the way jurors deal with forensic evidence in the context of other evidence and feedback about the way in which understanding such evidence could be increased were gained from both these studies. The comparison provides insights into the knowledge base of jurors, permitting adaptation of methods of presenting forensic information by lawyers and experts in court, based on evidence rather than folklore. While the Canadian juror data showed statistically significant findings that jurors are clearly influenced in their treatment of some forensic evidence by their television-viewing habits, reassuringly, no support was found in either study for the operation of a detrimental CSI effect as defined above. In the Australian study, in fact, support was found for the proposition that jurors assess forensic evidence in a balanced and thoughtful manner.     

STR primer concordance study.

Over 1500 population database samples comprising African Americans, Caucasians, Hispanics, Native Americans, Chamorros and Filipinos were typed using the PowerPlex 16 and the Profiler Plus/COfiler kits. Except for the D8S1179 locus in Chamorros and Filipinos from Guam, there were eight examples in which a typing difference due to allele dropout was observed. At the D8S1179 locus in the population samples from Guam, there were 13 examples of allele dropout observed when using the Profiler Plus kit. The data support that the primers used in the PowerPlex 16, Profiler Plus, and COfiler kits are reliable for typing reference samples that are for use in CODIS. In addition, allele frequency databases have been established for the STR loci Penta D and Penta E. Both loci are highly polymorphic.