Validation of the Seratec® SeraQuant™ for the quantitation of prostate-specific antigen levels on immunochromatographic membranes

Abstract: Use of immunochromatographic membranes for the detection of prostate‐specific antigen (PSA) has become commonplace in forensic laboratories. Experiments were designed to test the newly developed Seratec^® SeraQuant? for accuracy, precision, and consistency in the quantitation of PSA. PSA standards were diluted with buffers and run on the instruments. Values obtained were examined for accuracy (was the correct value obtained?) and precision (were multiple sample values consistent?). To test for variation between instruments, large volumes of diluted PSA standard were run repeatedly on six units and the values obtained were plotted against the known PSA values to obtain a standard curve for each instrument. Fifty membranes having negative or weak positive results were then run on the six units, and the adjusted values were recorded and compared. Results of these experiments indicate that the instruments are accurate and precise in the quantitation of low levels of PSA.     

Hopi Tradition as Jurisdiction: On the Potentializing Limits of Hopi Sovereignty

In this article I reconsider Hopi tradition as jurisdiction—reflexive moments of Hopi legal discourse that orient to the limits of Hopi sovereignty, even as they presuppose its power. I explore these themes in two significant moments of Hopi political history. First, I consider the uses of tradition in the creation of the contemporary Hopi tribe through the field notes of the US agent charged with drafting the 1936 Hopi Constitution. Then I consider more contemporary uses of tradition in recent Hopi tribal court cases that extended judicial power over matters reserved for local village leadership. Both instances suggest efforts to potentialize tribal power even as they orient explicitly to the limits of that authority. These traditions are thus, ironically, understood not as replaying Euro‐American logics of nationalist totalities, but as indigenous sociopolitical actions that unsettle static representations of Hopi cultural identity and the sovereignty claimed through them.     

Youth Psychopathy and Criminal Recidivism: A Meta-Analysis of the Psychopathy Checklist Measures

Although narrative reviews have suggested that "youth psychopathy" is a strong predictor of future crime and violence, to date no quantitative summaries of this literature have been conducted. We meta-analyzed recidivism data for the Psychopathy Checklist measures across 21 non-overlapping samples of male and female juvenile offenders. After removing outliers, psychopathy was significantly associated with general and violent recidivism (r (w)'s of .24 and .25, respectively), but negligibly related to sexual recidivism in the few studies examining this low base rate outcome. Even after eliminating outliers, however, considerable heterogeneity was noted among the effects, with some of this variability being explained by the gender and ethnic composition of the samples. Effect sizes for the small number of female samples available for analysis were mostly small and nonsignificant, and psychopathy was a weaker predictor of violent recidivism among more ethnically heterogeneous samples. In relation to predicting both general and violent recidivism, psychopathy performed comparably to an instrument designed specifically to assess risk, the Youth Level of Service/Case Management Inventory (Hoge & Andrews, 2002).     

Witness to a Miracle

This year marks the 40th anniversary of China's reform and opening up. Over the past four decades, the country has man-aged remarkable average annual GDP growth of 9.6 percent, a feat unprecedented in the history of human economic development.     

Further Validation of the Test of Memory Malingering (TOMM) Trial 1 Performance Validity Index: Examination of False Positives and Convergent Validity

Assessment of performance validity is an essential part of a neuropsychological evaluation, with the inclusion of two or more performance validity tests (PVTs) becoming routine practice. Considering the time to administer multiple tests, there has been some support for use of the Test of Memory Malingering (TOMM) Trial 1 (T1) as an independent, “one and done” PVT. Notably, cutoffs for TOMM T1 need further validation, with an emphasis on minimizing false-positive classifications among those with bona fide cognitive impairment. In a clinically referred sample of 127 veterans, this study examined the role of cognitive impairment in TOMM performance and the utility of a TOMM T1 as an independent PVT. Examinees were administered the TOMM and three additional PVTs as part of a comprehensive neuropsychological battery. Sixty-eight percent of examinees were classified valid (35% of valid examinees were cognitively impaired). TOMM T1?≤?40 had excellent observed sensitivity (83%) and specificity (93%) overall, with minimal false-positive classification. TOMM T1 was also significantly correlated and concordant with other memory-based PVTs. Given score ranges and failure rates for TOMM T1?≤?40 among those with neurological/neurocognitive conditions, scores in the 37–40 range may merit administration of additional TOMM trials to maximize accuracy in identifying valid-cognitively impaired versus noncredible performance. Otherwise, an abbreviated TOMM administration (i.e., only T1) using a cutoff of ≤?40—in conjunction with one or more additional PVTs—may be sufficient for detecting noncredible/invalid test performance in the absence of known or suspected neurological/neurocognitive disorders.     

Penal abolitionism: a different kind of reform

Rates of reoffending are high, both for people leaving prison and people on community sentences: the reconviction rate for all custodial sentences is 46.8 per cent, rising to 56.8 per cent for custodial sentences less than one year in duration. The reconviction rate for Community Orders is 36.8 per cent (Ministry of Justice, 2011).

Reoffending is expensive. Prison costs £45,000 per prisoner per year, plus £170,000 to build and maintain each new place (Prison Reform Trust, 2010). Cheaper community sentences can still cost £4,200 per offender per year. Many people in the criminal justice system have multiple and complex needs. For example, 72 per cent of male and 70 per cent of female sentenced prisoners suffer from two or more mental health disorders (ibid).     

Exploring Civic Engagement at an Urban Commuter Campus: Pathways and Barriers

Universities have traditionally had a vested interest in the civic preparation of students. In order to understand the unique situation of this population of students in a university serving non-traditional community students, qualitative data was used to identify pathways and barriers associated with their civic engagement. Results suggest themes associated with time, knowledge, and access.     

Geography,Globalization, and Terrorism: The Plots of Jemaah Islamiyah

Globalization and terrorism have become connected in many people's minds. I argue that the technologies of globalization, such as cheap transportation and telecommunications, do not in many circumstances liberate terrorist groups to attack throughout the world or necessarily grant them more power vis-à-vis states. In politically open environments, terrorist networks can behave much like legitimate jet-setting transnational organizations. When terrorist groups face state hostility, many of the tools of globalization become unavailable to them, and their activities become dependent on routes over any advantageous topographical features along states' boundaries, such as thick jungle, treacherous mountains, and tiny, isolated islands. This not only limits the territorial scope of the group's activities, but also means that the lack of these advantages can lead to failure. To illustrate this argument, I trace how the Southeast Asian terrorist group Jemaah Islamiyah (JI) planned two plots in 2000 and 2001: the Christmas Eve 2000 bombings in Indonesia, which succeeded, and the Singapore plots in 2001, which failed. The technologies of globalization were a great deal of help to JI during periods of political openness, but when it came under political pressure, the importance of geography and borders returned, particularly with regard to logistics.