Asymmetric septal hypertrophy of the heart. New findings concerning the possible etiology of sudden deaths in five males

This report describes certain interesting postmortem findings in the hearts of five subjects who died suddenly, silently, and unexpectedly, and in whom the only significant abnormality at autopsy was asymmetric septal hypertrophy (ASH) of the heart. Deep clefts, cystic faults, and dilated vascular channels were not only seen within the septal myocardium in all the hearts, but also within the left ventricular free walls of two hearts. The septal myocardium and the left ventricular free walls of two hearts and the A-V node and His bundle of one heart demonstrated mural and luminal thrombi of several dilated vascular channels. In another heart, foci of cardiocytic myofibrillar degeneration were seen, especially close to narrowed small coronary vessels. Fetal dispersion and fibrosis of the A-V node and His bundle were evident in one heart. These abnormalities in the conducting system and the ventricular myocardium suggest that the hearts of subjects with ASH are not only excellent anatomic substrates for lethal arrhythmias, but also are bound to be hemodynamically impaired. We believe that conditions such as hypoxia, increased oxygen demand by the heart or abnormal sympathetic stimulus may easily trigger fatal arrhythmias in such individuals, thereby causing sudden death.     

Biological factors and crime: implications for forensic psychiatry

To summarize, we can say that (1) Criminal behavior, especially chronic criminal behavior, seems to be partly genetically predisposed; (2) An important task at this point is to attempt to determine the biological factors which predispose people to crime; and (3) We have related some tentative initial steps being taken in the study of the autonomic nervous system as one possible heritable, biological basis for the failure of normal social learning forces in inhibiting criminal behavior. Early in this paper we discussed the tenability of asserting criminal responsibility on individuals whose criminal behavior has a partly genetic etiology. But this special consideration seems to set biological factors apart as being in some unique causal category. In fact, genetic, physiological, and biochemical factors are causal agents in the same sense as family, social class, or neighborhood factors. Of course, criminal behavior (like all other behavior) must be caused; one class of causal variables is the biological category. The legal doctrine of responsibility is not challenged by identifying biological factors as partially determining crime any more than it is by findings of social causation. Only in cases in which abnormal biological factors are exceptionally powerful influences might responsibility be challenged. Such cases will be quite rare.     

Transfer of nitroglycerine to hands during contact with commercial explosives

The techniques of thin-layer chromatography, gas chromatography with electron capture detection, and gas chromatography/mass spectrometry were used to analyze hand swab extracts for the presence of nitroglycerine. Both the amount of nitroglycerine transferred to the hands after handling commercial explosives and its persistence were measured. Gas chromatography-electron capture detection was found to be the most accurate and sensitive technique for making such determinations, especially if the extract was partially purified by thin-layer chromatography prior to analysis. The lowest limit of detection was 10 ng of nitroglycerine, and residues could be detected over 20 h after handling the raw explosive.     

An investigation of bulk and surface refractive indices for flat window glasses,patterned window glasses and windscreen glasses

The bulk and surface refractive indices have been measured for 20 float window glasses, 20 non-float window glasses, 20 patterned window glasses and 20 toughened float windscreen glasses.The refractive index of the tin-contact surface of the float glasses was always greater than that of the bulk, typically by 0.002 (range 0.00053–0.00307). In contrast the refractive indices of the two surfaces and the bulk of the sheet window glasses were in agreement within accepted experimental error in each case. A number of patterned window glasses showed significantly different refractive indices between the plain and patterned surfaces, the largest difference obtained (0.00021) being an order of magnitude smaller than that found for a typical float glass.Nine of the 40 float glasses examined yielded abnormal fragments from the upper surface in the sense that they did not disappear at the match temperature of the bulk glass. The refractive index measured from these abnormal fragments for two of these glasses was lower than the refractive index from the bulk glass.The variation in the bulk refractive index for the sheet and float window glasses produced an estimated standard deviation (E.S.D.) of 1.2 × 10^?5. However, the patterned glasses were nearly three times as variable (E.S.D. = 3.3 × 10^?5) and the toughened float glasses were, on average, almost seven times as variable (E.S.D. = 8.0 × 10^?5).The value of making surface as well as bulk refractive index measurements in routine casework is discussed in the light of the above results.     

A new computer-assisted possibility for evaluating the evidence value of textile fiber traces

This paper deals with the possibility of coding synthetic textile fibers. Using a small data bank the efficiency of a computer aided data search is demonstrated. It is intended to build up a large collection of textile fibers and to determine at least approximately the frequency of a certain fiber type. If this can be achieved the forensic scientist who has to examine textile fibers in case work will be able for the first time to answer the question about the frequency of an incriminating fiber, a question which is often asked in court.     

Problems in using high performance liquid chromatography for drug analysis

Some problems encountered in using high performance liquid chromatography (HPLC) for drug analysis are discussed. These include high procurement and operational costs, lengthy training required, excessive downtimes , lower precision in HPLC versus gas chromatography (GC) and lack of a universal sensitive detector. Some solutions to these difficulties are presented.