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Three commercially available integrated rapid DNA instruments were tested as a part of a rapid DNA maturity assessment in July of 2018. The assessment was conducted with sets of blinded single-source reference samples provided to participants for testing on the individual rapid platforms within their laboratories. The data were returned to the National Institute of Standards and Technology (NIST) for review and analysis. Both FBI-defined automated review (Rapid DNA Analysis) and manual review (Modified Rapid DNA Analysis) of the datasets were conducted to assess the success of genotyping the 20 Combined DNA Index System (CODIS) core STR loci and full profiles generated by the instruments. Genotype results from the multiple platforms, participating laboratories, and STR typing chemistries were combined into a single analysis. The Rapid DNA Analysis resulted in a success rate of 80% for full profiles (85% for the 20 CODIS core loci) with automated analysis. Modified Rapid DNA Analysis resulted in a success rate of 90% for both the CODIS 20 core loci and full profiles (all attempted loci per chemistry). An analysis of the peak height ratios demonstrated that 95% of all heterozygous alleles were above 59% heterozygote balance. For base-pair sizing precision, the precision was below the standard 0.5 bp deviation for both the ANDE 6C System and the RapidHIT 200.  相似文献   
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This study examined concurrent and lagged effects of deviant peer association on levels of alcohol use for distinctive trajectories of drinking from ages 14–18 years, while controlling for age, paternal education, community size, and conduct problems. Longitudinal data were available from a secondary data archive of male and female German adolescents (N = 1,619). Conditional latent growth mixture modeling analysis indicated consistent concurrent effects of deviant peer association (specified as time-varying covariate) on alcohol use for the regular users group, but not any of the other drinking trajectory groups. Very few lagged effects of deviant peers association on alcohol use were found, and thus the social influence hypothesis received little empirical support. Overall, findings suggest the need to consider heterogeneity in the study of peer characteristics and alcohol use for both male and female adolescents.
Karina WeicholdEmail:

Dr. Margit Wiesner   received her Doctoral degree in 1999 from the Friedrich Schiller University of Jena (Germany) and currently is Assistant Professor in the Department of Educational Psychology at the University of Houston. Research interests include developmental trajectories of offending and other problem behaviors, and psychosocial transitions during adolescence and young adulthood. Dr. Rainer K. Silbereisen   received his Doctoral degree in 1975 from the Technical University of Berlin (Germany) and currently is Professor and Chair of the Department of Developmental Psychology at the Friedrich-Schiller-University (FSU) of Jena. He is also Director of the Center for Applied Developmental Science at FSU. His main research interests concern human development across the life-span, particularly concerning adolescence and early adulthood. He has directed several longitudinal projects on problem behavior in adolescence, effects of early adversities on the timing of psychosocial transitions, the impact of social change on adolescent development, acculturation among immigrants, and bio-behavioral aspects of adolescent development. Dr. Karina Weichold   received her Doctoral degree in 2002 from the Friedrich Schiller University of Jena (Germany) and currently is Assistant Professor in the Department of Developmental Psychology at the Friedrich-Schiller-University (FSU) of Jena. Her research topics include adolescent alcohol consumption in times of social change, biopsychosocial mechanisms of maladaptation during puberty and adolescence, and interventions for adolescent problem behavior.  相似文献   
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Individuation, a process whereby adolescents gain autonomy from their parents while maintaining emotional relatedness, is displayed by characteristic styles of verbal exchanges. Negotiating this developmental transition is often stressful for adolescents and their parents. This study deals with the association between pubertal timing, communication behaviors, and stress reactivity assessed during young females’ conflict discussions with their mothers. A sample of N = 32 girls (age 9–13, T1) was grouped by pubertal timing. Years later (age 17–22, T2) they were followed up and videotapes of daughter–mother conflict discussions were evaluated. Salivary alpha-amylase was used to assess the stress reactivity. Results revealed that young women who had entered puberty early were higher in striving for control and separation in interactions with their mothers, and displayed higher stress levels. These results pointed to less successful individuation in late adolescence/young adulthood compared to on-time and late maturing age mates.
Rainer K. SilbereisenEmail:

Karina Weichold   is an Assistant Professor of Developmental Psychology, University of Jena, Germany. Received PhD in 2002 from the University of Jena, Germany. Major research interests: Development of problem behaviors and positive adaptation during adolescence in times of social change, with focus on biopsychosocial risk and protective mechanisms, and application of findings on prevention and promotion programs. Sabine Büttig   is a Clinical Psychologist working at the Hospital Weinsberg, Germany. Received PhD in 2007 from the University of Jena, Germany. Major research interests: Long-term consequences of inter-individual differences during puberty. Rainer K. Silbereisen   is a Professor and Head of the Department of Developmental Psychology, and Director of the Center for Applied Developmental Science (CADS), University of Jena, Germany. He is also Adjunct Professor of Human Development and Family Studies at the Pennsylvania State University (USA). Received PhD in 1975 from the Technical University of Berlin, Germany. Major research interests: Interdisciplinary large scale research on the role of social change in positive and maladaptive human development, utilizing a cross-cultural and biopsychosocial format.  相似文献   
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Residential care work is currently characterized by two rationalization processes: a professionalization of care and a commodification of health care. From both developments may arise conflicting demands and claims for the caregivers themselves, involving a change in the action guiding basis for orientations and the notions of “good care”. Textbooks are a key foundation for the development of the nursing self-image. Based on a longitudinal qualitative and quantitative content analysis of a classic nursing education textbook a transformation process from rational caring orientations to economic orientations can be shown. This is interpreted as a hybridization of the profession rationality of care, as part of the dual nature of care: on the one hand as a concretely useful rational caring work and on the other hand as a cost-benefit calculated production and exploitation process.  相似文献   
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On 18 January 2005, Danish Prime Minister Anders Fogh Rasmussen called for a general election to be held on 8 February 2005, nine months before the deadline for the next election. Political themes are usually cited when calling Danish elections, but this time the calendar was used as an excuse: because of major reforms to the municipal structure, a significant amount of legislation had to be negotiated and settled in the spring, and it was unclear whether this could be done by June, thereby hindering an election in late spring; and an election in September could possibly overshadow the important elections to the new municipal councils (created as a result of the reform) in November. Nevertheless, favourable opinion polls undoubtedly also played a major role when the Prime Minister asked the Danes to renew and extend the mandate of his Liberal–Conservative (aka Venstre–Conservative) coalition government.  相似文献   
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