Fixed-dose isosorbide dinitrate-hydralazine: race-based cardiovascular medicine benefit or mirage?

Race is not a scientific category, but African Americans have increased prevalence and severity of heart failure. The African American Heart Failure trial showed the benefit of a combination of isosorbide dinitrate (a nitric oxide donor) and hydralazine (an antioxidant). Future research may unmask the reason for cardiovascular differences in therapy.     

Semiotic technologies: a case study of discipline-based practices and pedagogy

This paper examines semiotic technologies, both in terms of the resources they harness and the practices developed around their use. It draws on data collected as part of an ethnographic investigation into the meaning-making practices deployed within civil engineering study. The data is used as a case study for examining semiotic technologies as socially situated resources for disciplinary practices. Using a multimodal social semiotic approach, we argue that technologies are not self-evident, and that their use constitutes specific social practices that require development in the classroom. In order to deploy technologies in pedagogically effective ways, we need to understand the semiotic resources they draw on (including embodied resources). Awareness that technologies are not neutral or value-free, but are socially situated and ideologically laden, may enable meta-level understanding of the discipline, thus creating the possibility for improved pedagogical practices.     

Inter-species variation in bone mineral behavior upon heating

The characterization of inter-species variation in bone mineral (b-HAP) is of relevance to forensic science and archaeology, but has not previously been widely explored. Results of an investigation into unheated bone mineral and behavior of bone upon heating for 12 animal species (including human) demonstrate that b-HAP characteristics, quantitatively measured using X-ray diffraction (XRD) analysis, exhibit significant inter-species variation. Human bone was found to be significantly different to all other species in terms of b-HAP lattice parameter values from unheated and heated bone and in terms of recrystallization behavior of b-HAP upon heating bone to 600°C. The amounts of b-HAP thermal decomposition products were also significantly different for human bone heated to 1400°C compared to those obtained for most other species. Therefore, there is potential for the development of an XRD-based method of species identification, particularly one that distinguishes human from non-human bone.     

Visualisation of fingermarks and grab impressions on fabrics. Part 1: gold/zinc vacuum metal deposition

Vacuum metal deposition (VMD) is a highly sensitive technique originally introduced for detecting latent fingermarks on smooth non-porous surfaces such as carrier bags, plastics and glass. The current study explores whether VMD can be used in the examination of clothing from physical and sexual assault cases in order to visualise identifiable fingermark ridge detail and/or palmar flexion crease detail, thus allowing potential areas to be indicated for DNA swabbing and/or to determine the sequence of events. Four different fabrics were utilised during this study - nylon, polyester, polycotton and cotton, along with 15 donors who ranged in their age and propensity to leave fingermarks, from good to medium to poor as determined by results obtained from test runs using paper and plastic carrier bags processed with VMD. Once samples were collected they were kept for a determined time (1, 2, 3, 4, 5, 6, 7, 14, 21 or 28 days) and then treated using the gold/zinc metal VMD process. From the results, it appears that greater ridge detail is visible on the smoother non-porous fabrics, such as nylon whereas on rougher porous fabrics, such as cotton, only empty prints and impressions, rather than any ridge details, were visible. All fabrics did however allow the development of touch marks that could be targeted for DNA taping thus potentially leading to a DNA profile and possible identification of a suspect.     

Self-protective behaviors and injury in domestic violence situations: does it hurt to fight back?

Research examining the impact of self-protective behaviors on outcomes in nonsexual assaults involving intimates has focused solely on one mainstream sample (National Crime Victimization Survey) in which violence is a relatively rare event. Using the Women's Experience of Violence (WEV) project which collects data from a sample of incarcerated women, we explored the phenomenon of self-protective behaviors to assess whether their use impacts the probability and severity of subsequent injury during a domestic violence incident. In addition to utilizing a unique sample, we considered an alternative operationalization of self-protective behaviors that separates physical and verbal responses to include whether the behavior involved an element of force. Results suggest some similarities between a mainstream sample and our marginalized sample. Namely, the frequency in which they utilize countermeasures and the effect of "fighting back" appear to be consistent with previous research. However, the more nuanced categorization of self-protective behaviors demonstrates the importance of considering whether the strategy was forceful when examining women's responses to violence.