Short term impact of Tribulus terrestris intake on doping control analysis of endogenous steroids

Tribulus terrestris is a nutritional supplement highly debated regarding its physiological and actual effects on the organism. The main claimed effect is an increase of testosterone anabolic and androgenic action through the activation of endogenous testosterone production. Even if this biological pathway is not entirely proven, T. terrestris is regularly used by athletes. Recently, the analysis of two female urine samples by GC/C/IRMS (gas chromatography/combustion/isotope-ratio-mass-spectrometry) conclusively revealed the administration of exogenous testosterone or its precursors, even if the testosterone glucuronide/epitestosterone glucuronide (T/E) ratio and steroid marker concentrations were below the cut-off values defined by World Anti-Doping Agency (WADA). To argue against this adverse analytical finding, the athletes recognized having used T. terrestris in their diet. In order to test this hypothesis, two female volunteers ingested 500 mg of T. terrestris, three times a day and for two consecutive days. All spot urines were collected during 48 h after the first intake. The ¹³C/¹²C ratio of ketosteroids was determined by GC/C/IRMS, the T/E ratio and DHEA concentrations were measured by GC/MS and LH concentrations by radioimmunoassay. None of these parameters revealed a significant variation or increased above the WADA cut-off limits. Hence, the short-term treatment with T. terrestris showed no impact on the endogenous testosterone metabolism of the two subjects.     

Opposition Discourses in European Democracies: A Rhetorical Approach

Through this article, I explore the issue of tolerance in the Western thought from a rhetorical perspective. I assume that the 1948 Universal Declaration of Human Rights reflects the framework in which Europeans democracies argue and think today. Consequently, I analyze the Universal Declaration with the help of Toulmin’s model in order to put its backing into light, and compare it to the 1789 Declaration of the Rights of Man. This backing, I argue, echoes the contemporary vision of tolerance in Western democracies. Afterwards, I therefore analyze the concept of tolerance in a multicultural world. This reflection comes within the scope of the current researches in rhetoric as they were launched by Perelman’s Treatise on Argumentation first published in 1958. Having inherited from the 19th-century renewed interests in linguistics and semiotics, the contemporary researches assume an evolutionary and anthropological perspective on rhetoric and argumentation, seen as natural activities of human beings. This discipline, notably developing in the school of Brussels in argumentation [See Danblon, Emmanuelle, La Fonction Persuasive, Paris: Armand Colin, 2002], inspires itself both from Aristotle’s works and from the cognitive movement in contemporary linguistics. It seeks to establish a link between the emergence of rationality and rhetoric and takes its grounds in cognitive sciences as well as anthropological studies, philosophy, logics and theories of emotions. At present, it addresses several issues such as the status of rationality, persuasion and the place of rhetoric and argumentation in contemporary societies. Additional support was provided by the National Science Foundation.     

Saving behaviour of citrus farmers in Ghana: implications for rural enterprise development

This article reports on a study that examined the saving behaviour of farmers in southern Ghana, using a sample of 100 citrus farmers. Probit and Tobit models were used in determining the factors that influence farmers’ saving behaviours and amount of saved, respectively. The empirical findings showed that age, household size, dependency, marital status, distance to financial institution, transport cost and congestion exerted significant negative impact on farmers’ saving behaviours. On the other hand, income, education, and gender tended to promote good saving behaviour. The article concludes that heterogeneity of factors ranging from socio-economic, household assets, and institutional factors greatly stimulate farmers’ saving behaviour.     

The Great Illusion: Tort Law and Exposure to Danger of Physical Harm

In the aftermath of Gregg v Scott and Johnston v NEI , it is commonly thought that claims for exposure to danger of physical harm are not independently compensatable in English law. I argue that this assumption is doubly mistaken. On the one hand, claimants exposed to danger of physical harm have a compelling argument of principle for the recovery of any significant increase in the cost of their options for dealing with the carelessly heightened danger to their physical health. On the other hand, that argument of principle is not blocked by Gregg , or other cases in the line of precedent consolidated in that decision. Properly construed, the rejection of the plaintiff's claims in Gregg and Johnston is consistent with a right of recovery for significant costs following from careless exposure to danger of physical harm.     

Intelligence in Occupied Belgium: The Business of Anglo-Belgian Espionage and Intelligence Cooperation during the Two World Wars (1914–1918, 1940–1944)

During both World Wars, one of the most powerful weapons Belgian citizens possessed in resisting German occupation of their country was the gathering of intelligence on the enemy for the allied armies. But Belgian's first and second secret wars were different in several respects, one of the most important being the relationship between the Belgian secret services in exile and their British counterparts. If the First World War was essentially a story of bitter concurrency between them, the Second was mostly a tale of ‘jealous’ partnership. The relations with the intelligence networks in occupied Belgium formed a delicate but crucial issue, where money played an important role. This article explores these dynamics and how they affected the main mission of gathering intelligence on the Germans.     

Application of 3D Imaging Technology to Latent Fingermark Aging Studies

In most latent fingermark aging studies, two‐dimensional (2D) features are obtained from photo images, scans, or inked impressions. However, some relevant information is possibly being missed because fingermarks are three‐dimensional (3D) objects that age in all three dimensions. A feature that has not been carefully examined is how the height of ridges changes over time. In this report, a 3D imaging technology—called optical profilometry—is introduced as a tool for the visual examination of the aging process. Optical profilometry is a nondestructive technology that allows the visualization and data acquisition of unprocessed latent fingermarks. Detailed ridge images and spatiotemporal data were successively obtained on the x‐, y‐ and z‐axis, delivering 3D topographical information. OP was able to detect the loss of ridge heights over time. The feasibility of employing this technology to collect data on the aging process of ridges has been proven.     

Study of steroidogenesis in pupae of the forensically important blow fly Protophormia terraenovae (Robineau-Desvoidy) (Diptera: Calliphoridae)

Protophormia terraenovae is a forensically important fly whose development time is studied by forensic entomologists to establish the time elapsed since death (post-mortem interval, PMI). Quantity and nature of ecdysteroid hormones present in P. terraenovae pupae were analysed in order to determine if they could be correlated to the age of pupae found on corpses and thereby could give information on the PMI. Ecdysteroid levels were quantified during the pupal-adult development of synchronised animals using enzyme immunoassay (EIA), a sensitive method allowing acurate quantification in one pupa. Two types of pupae were compared: "fresh" pupae, kept frozen until analysis and "experimentally dried" pupae, which were left for several weeks at ambient temperature. A peak of ecdysteroids was detected between 36 and 96 h after pupariation in fresh animals. It was not observed in "experimentally dried" pupae. High-pressure liquid chromatography (HPLC) analyses combined with EIA showed that 20-hydroxyecdysone (20E) was the major free ecdysteroid at various pupal ages. Enzymatic hydrolysis experiments revealed the presence of apolar conjugates at all ages tested. However, neither qualitative nor quantitative difference was detected between early and late pupae. This study gives precise information on the nature and quantity of ecdysteroids in the course of pupal development of a calliphorid fly. The limits of using ecdysteroid measurement as a tool in forensic entomology are discussed.     

The viability of the welfare state in Botswana

ABSTRACT

Vulnerability, mainly manifesting in poverty, economic risk and insecurities of life, is a universal problem. There are huge pockets of vulnerability in the developing world, particularly Sub-Saharan Africa. Sub-Saharan African states provide social welfare goods to address vulnerability. Social welfare programmes cost money, hence, there is a need to consider issues of sustainability, particularly, given constrained revenue envelopes. Similarly, while Botswana has posted developmental successes, there are vulnerabilities such as poverty, unemployment and income inequality which demand intervention through welfare programmes. Thus, the objective of this desktop study was to discuss the state's response to vulnerability. It concluded that Botswana funds welfare programmes. However, there are affordability challenges, mainly, a constrained post-2007 fiscal space calls into question the viability of the welfare state. The general lesson from the case is that while the welfare state goes to the heart of the social contract, its viability must be guaranteed through reforms.