High prevalence of 6-acetylmorphine in morphine-positive oral fluid specimens

Identification of 6-acetylmorphine, a specific metabolite of heroin, is considered to be definitive evidence of heroin use. Although 6-acetylmorphine has been identified in oral fluid following controlled heroin administration, no prevalence data is available for oral fluid specimens collected in the workplace. We evaluated the prevalence of positive test results for 6-acetylmorphine in 77,218 oral fluid specimens collected over a 10-month period (January-October 2001) from private workplace testing programs. Specimens were analyzed by Intercept immunoassay (cutoff concentration=30 ng/ml) and confirmed by GC-MS-MS (cutoff concentrations=30 ng/ml for morphine and codeine, and 3 ng/ml for 6-acetylmorphine). Only morphine-positive oral fluid specimens were tested by GC-MS-MS for 6-acetylmorphine. A total of 48 confirmed positive morphine results were identified. An additional 107 specimens were confirmed for codeine only. Of the 48 morphine-positive specimens, 32 (66.7%) specimens were positive for 6-acetylmorphine. Mean concentrations (+/-S.E.M.) of morphine, 6-acetylmorphine and codeine in the 32 specimens were 755+/-201, 416+/-168 and 196+/-36 ng/ml, respectively. Concentrations of 6-acetylmorphine in oral fluid ranged from 3 to 4095 ng/ml. The mean ratio (+/-S.E.M.) of 6-acetylmorphine/morphine was 0.33+/-0.06. It is suggested that, based on controlled dose studies of heroin administration, ratios >1 of 6-acetylmorphine/morphine in oral fluid are consistent with heroin use within the last hour before specimen collection. The confirmation of 6-acetylmorphine in 66.7% of morphine-positive oral fluid specimens indicates that oral fluid testing for opioids may offer advantages over urine in workplace drug testing programs and in testing drugged drivers for recent heroin use.     

The self-defense defense and community sentiment

It has been asserted (e.g., Gillespie, 1989) that the self-defense defense, with its objectivereasonable man standard, is unfairly biased against certain female defendants who kill a male and plead not guilty by reason of self-defense (NGRSD), and that jurors, who represent community sentiment, share that bias. Using three cases where a woman kills and pleads self-defense (a battered woman case, aGoetz-like subway case, and an alleged rape case), whereseriousness of the harm, equal or unequal force, retreat/escape possibility, imminence, and thepresence and type of expert testimony were varied, 269 mock jurors (students and adults) rendered verdicts and ratings. Broad but variable support for the NGRSD was found (e.g., 63%, 27%, and 23% NGRSD verdicts in the battered woman, subway, and rape cases, respectively), along with evidence that subjects use a wider context and, at times, a subjective perspective to decide culpability. Implications for a self-defense defense are suggested.     

The Transfer of Manufacturing Processes and Standards in U.S. Plants Operating in the U.K.

This paper finds that U.S. firms tend to utilize their manufacturing processes when operating in the U.K. but that they adopt the production standards of the host country. Three process technology variables are examined: MRP I (materials requirements planning), JIT (just in time), and TQM (total quality management). While significant differences are found between indigenous plants in each of the two countries, the adoption of these manufacturing technologies is similar for American firms operating in either country. In contrast, U.S. transplants are found to be enthusiastic adopters of ISO 9000, suggesting that host country effects are large when it comes to conforming to regional standards.     

Trade unions,NGOs, and corporate codes of conduct

The proliferation of corporate codes of conduct generates both alliance and tension between trade unions and NGOs that deal with workers' rights in the global economy. Alliance, because trade unions and NGOs share a common desire to halt abusive behaviour by multinational companies and a broader goal of checking corporate power in the global economy. Tension, because unions and NGOs have differing institutional interests, different analyses of problems and potential solutions, and different ways of thinking and talking about social justice in the global economy. There are fears that codes of conduct may be used to undermine effective labour law enforcement by governmental authorities and undermine workers' power in trade unions. The substance behind the rhetoric on this new generation of corporate codes of conduct is certainly open to question. However, this paper argues that, given unions' weak presence in the global assembly line and the rapid‐response capabilities of many NGOs, such codes are a valuable asset. Trade unions and NGOs still have more in common with each other than either has with corporations, governments, or international organisations that see free trade and free‐flowing capital as the solution to low labour standards. But both need to be clear‐eyed about their differences and their proper roles as they navigate the opportunities and challenges that lie ahead.     

Welfare gains from optimization in dynamic planning models

This paper compares the results of two multisectoral models used to plan the dynamic consistency of sectoral investment. Solution of an optimizing model forecasts a frontier of the economy's future choice set. This frontier represents a ten year welfare gain only 2 or 3 percent greater than any investment program simulated by a dynamic Leontief system. The paper explains what efficient behavior accounts for the “better” performance of the optimizing model. Developing dynamic programming models is costly in terms of data, computational complexity, man-machine interaction, and solution interpretation. Therefore, it is recommended that the lessons derived by working with the dynamic LP be applied to improve the planner's control of the less expensive input/output simulation model.     

Teaching technology decision making for product design and development: A university course on technology assessment and technology transfer

Engineers deploy their skills in contexts that require decisions based on certain criteria and on an understanding of processes that were not learned in college. This paper explores how these supplemental, “contextual” skills may be taught and reports on an experimental, fairly successful upper-division course at Pennsylvania State University in the fall of 1995.