Predicting Life Satisfaction During Middle Adulthood from Peer Relationships During Mid-Adolescence

The immediate advantages of adolescent friendships and disadvantages of peer rejection are well documented, but there is little evidence that these effects extend into adulthood. This study tested the hypothesis that peer relationships during adolescence predict life satisfaction during middle adulthood, using data from a 30-year prospective longitudinal study. Participants included 996 (49.5 % female) 8th grade students from a community sample of Swedish youth. Self-reports of friendship and peer reports of rejection were obtained when participants were age 15. Self-reports of global life satisfaction and perceived relationship quality were collected at age 43 for women and age 48 for men. Path analyses tested a direct-effects model that examined links from adolescent friendship participation and peer rejection to middle adulthood outcomes, and a buffered-effects model that examined links from adolescent peer rejection to middle adulthood outcomes, separately for those with and without friends during adolescence. Strong support emerged for the buffered-effects model but not the direct-effects model. Adolescent friendship participation moderated associations between adolescent peer rejection and adult global life satisfaction and between adolescent peer rejection and adult perceived relationship quality such that peer rejection predicted poorer adult outcomes for youth without friends but not for youth with friends. The findings suggest that the risks of peer rejection—and benefits of friendship—extend from adolescence well into middle age.     

When do societal stakeholders matter for agency-CEOs? The role of stakeholder arrangements and social media attention

Public agencies have to deal with accountability demands from various societal stakeholders. Stakeholders may address their accountability demands via formal stakeholder arrangements but can also use social media for account-holding purposes. This contribution analyzes to what extent these different venues of social accountability affect the perceived relevance of societal stakeholders to agency-CEOs—their so-called “stakeholder orientation.” By combining quantitative and qualitative data, this study shows that agency-CEOs' stakeholder orientation is strongly associated with actual social media attention. In contrast, the relationship between formal stakeholder arrangements and stakeholder orientation is weak. Qualitative insights from focus group discussions suggest that the associations between social media attention and stakeholder orientation can be explained by mediatization processes within agencies and the reputational risks of social media storms. Overall, the findings support that social media attention is the most important catalyst for stakeholder orientation, rather than stakeholder arrangements.     

From Research Evidence to “Evidence by Proxy”? Organizational Enactment of Evidence‐Based Health Care in Four High‐Income Countries

Drawing on multiple qualitative case studies of evidence‐based health care conducted in Sweden, Canada, Australia, and the United Kingdom, the authors systematically explore the composition, circulation, and role of codified knowledge deployed in the organizational enactment of evidence‐based practice. The article describes the “chain of codified knowledge,” which reflects the institutionalization of evidence‐based practice as organizational business as usual, and shows that it is dominated by performance standards, policies and procedures, and locally collected (improvement and audit) data. These interconnected forms of “evidence by proxy,” which are informed by research partly or indirectly, enable simplification, selective reinforcement, and contextualization of scientific knowledge. The analysis reveals the dual effects of this codification dynamic on evidence‐based practice and highlights the influence of macro‐level ideological, historical, and technological factors on the composition and circulation of codified knowledge in the organizational enactment of evidence‐based health care in different countries.     

Investigation of morphine and morphine glucuronide levels and cytochrome P450 isoenzyme 2D6 genotype in codeine-related deaths

Compared to morphine and morphine-6-glucuronide (M6G), codeine and its other major metabolites codeine-6-glucuronide and norcodeine have weak affinity to opioid μ-receptors. Analgesic effects of codeine are thus largely dependent on metabolic conversion to morphine by the polymorphic cytochrome P450 isoenzyme 2D6 (CYP2D6). How this relates to toxicity and post-mortem whole blood levels is not known. This paper presents a case series of codeine-related deaths where concentrations of morphine, M6G and morphine-3-glucuronide (M3G), as well as CYP2D6 genotype, are taken into account. Post-mortem toxicological specimens from a total of 1444 consecutive forensic autopsy cases in Central Norway were analyzed. Among these, 111 cases with detectable amounts of codeine in femoral blood were identified, of which 34 had femoral blood concentrations exceeding the TIAFT toxicity threshold of 0.3mg/L. Autopsy records of these 34 cases were retrieved and reviewed. In the 34 reviewed cases, there was a large variability in individual morphine to codeine concentration ratios (M/C ratios), and morphine levels could not be predicted from codeine concentrations, even when CYP2D6 genotype was known. 13 cases had codeine concentrations exceeding the TIAFT threshold for possibly lethal serum concentrations (1.6 mg/L). Among these, 8 individuals had morphine concentrations below the toxic threshold according to TIAFT (0.15 mg/L). In one case, morphine as well as M6G and M3G concentrations were below the limit of detection. A comprehensive investigation of codeine-related fatalities should, in addition to a detailed case history, include quantification of morphine and morphine metabolites. CYP2D6 genotyping may be of interest in cases with unexpectedly high or low M/C ratios.     

Whole body postmortem magnetic resonance angiography

Computed tomography (CT) and magnetic resonance (MR) imaging have become important elements of forensic radiology. Whereas the feasibility and potential of CT angiography have long been explored, postmortem MR angiography (PMMRA) has so far been neglected. We tested the feasibility of PMMRA on four adult human cadavers. Technical quality of PMMRA was assessed relative to postmortem CT angiography (PMCTA), separately for each body region. Intra-aortic contrast volumes were calculated on PMCTA and PMMRA with segmentation software. The results showed that technical quality of PMMRA images was equal to PMCTA in 4/4 cases for the head, the heart, and the chest, and in 3/4 cases for the abdomen, and the pelvis. There was a mean decrease in intra-aortic contrast volume from PMCTA to PMMRA of 46%. PMMRA is technically feasible and allows combining the soft tissue detail provided by MR and the information afforded by angiography.     

The 1972 Memorandum to the United Nations and its repercussions: Émigré politics and Soviet Estonian dissent during the ‘era of stagnation’

The Estonian dissidents’ Memorandum to the United Nations, drafted as a call for national self-determination in 1972, set new standards for the émigré community’s campaigns. Although its political message was initially dismissed as utopian, the subsequently emerging cooperation between émigré and homeland activists via intricate courier networks significantly strengthened the authority of Estonian voices in the West. By the early 1980s, the political alliances across the Iron Curtain eventually bore fruit. The Memorandum’s core demands reappeared in political debates on Baltic issues on both sides of the Atlantic, foreshadowing the massive Western support for the Baltic cause during the Singing Revolutions.