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61.
The stability of five commonly prescribed barbiturates and thiopental in blood and liver at room temperature and at 4 degrees C was studied. Gas chromatography was used for oxybarbiturate analysis while liquid chromatography was used to quantitate thiopental. In blood and liver, greater than 75% of the drugs were detected at the end of the two- to three-month period. These changes were not considered significant; therefore, barbiturates appear to be stable in blood and liver under the conditions of these experiments. 相似文献
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A case is presented of a 54-year-old white female found dead in a secured apartment. Postmortem toxicologic analysis of the heart blood identified acetaminophen (97 mg/L), citalopram (0.4 mg/L), gabapentin (24 mg/L) and metaxalone (21 mg/L). The metaxalone concentration is within the range of previously reported fatalities involving metaxalone. The medical examiner ruled that the cause of death was metaxalone and gabapentin intoxication and the manner of death was suicide. 相似文献
66.
B Levine T King J P Pestaner J E Smialek 《The American journal of forensic medicine and pathology》2001,22(1):62-64
An 83-year-old woman with a history of Alzheimer's disease and breast cancer died at home while receiving palliative pain therapy with oral morphine from her family for metastatic breast cancer. Allegations of mistreatment were made, and this case was ultimately referred to the Office of the Chief Medical Examiner, State of Maryland. An autopsy failed to identify any injuries or residual cancer, leaving no anatomic explanation for the pain that had been presumed to be metastatic breast carcinoma involving bone. The blood free morphine concentration was 5,200 ng/ml, and the total morphine concentration was 15,000 ng/ml. This case demonstrates the challenges and difficulties in forensic medicine when faced with the interpretation of toxicologic results at the end of life. 相似文献
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F J Peretti D S Isenschmid B Levine Y H Caplan J E Smialek 《Forensic science international》1990,48(2):135-138
A case is presented of a 26-year-old female who died as a result of cocaine intoxication. A blood cocaine concentration of 330 mg/l, about 1.5 times greater than the highest concentration previously reported, was found. Blood benzoylecgonine and ecgonine methyl ester concentrations were 50 and 18 mg/l, respectively. The unusually high blood concentrations of cocaine and the metabolites are suggestive of a massive administration, however, the history suggests a series of recreational uses. The manner of death was undetermined. 相似文献
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Bret L. Billet Jan Knippers Black Daniel H. Levine Maristella Botticini Allan C. Reddy Lawrence S. Graham Harvey Glickman Fred H. Lawson Thomas U. Berger Paul W. Kuznets Yuan-li Wu Marianne A. Ferber Stephen P. Mumme Dilmus D. James Alison Brysk Carrie A. Meyer Juan M. del Aguila Robert W. Anderson Walter C. Opello M. C. Hallberg Luth Tweenten Anderson Professor 《Studies in Comparative International Development (SCID)》1994,29(3):84-126
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A Convit S Levine S Berns C Evangelista 《The Bulletin of the American Academy of Psychiatry and the Law》1991,19(2):185-191
We sought to explore the relationship between type of psychopathology and consent bias. Using the Brief Psychiatric Rating Scale we assessed a group of 48 forensic psychiatric inpatients. These patients were later independently approached by a researcher who attempted to get their consent for a study on the validity of self-reported criminal behavior. Thirty agreed to participate and 18 did not. The consenting patients were significantly younger and had significantly more negative symptoms than the nonconsenters. The difference in negative symptoms remained significant after age and medication dose, in chlorpromazine equivalents, were covaried out. The authors discuss the implications of these findings for forensic research. 相似文献