知识产权许可策略探讨

中国已成为一个巨大的知识产权许可市场.中国企业在考虑将知识产权许可作为知识产权管理战略的一部分时,有必要做出几个关键决策:是否该取得许可、许可内容以及许可来源.知识产权许可有助于中国公司取得有价值的技术、节省研发费用并避免商业化的延宕.     

VAAs as sources of volatility and fragmentation: self-selection effects and genuine effects

ABSTRACT

Recent studies show that using Voting Advice Applications (VAAs) affects party preferences of voters, and hence leads to party switching. Party switching is a necessary but insufficient condition for volatility (a net switch of voters to other parties) and fragmentation (more parties gaining seats) at the aggregate level of electoral constituencies. The research question addressed here is whether the availability of VAAs in electoral constituencies weakens or strengthens trends towards greater volatility and fragmentation as observed in western democracies in the last decades. The data come from 380 Dutch municipalities during the 2014 Dutch municipal council elections. In 133 of them a VAA was available. Using a moderated mediation model that controls for the municipal self-selection of a VAA, we find that a VAA by itself leads to higher levels of volatility and fragmentation. However, VAA availability has a dampening effect in municipal constituencies with characteristics (e.g. population size, ethnic diversity, young average age) that would otherwise make them more susceptible and prone to volatility and fragmentation.     

Contestable constitutions: Ambiguity,conflict, and change in East Central European dual executive systems

This article investigates how ambiguous constitutional design affected president–cabinet relations and constitutional change in post-communist Poland and Hungary. Constitutional provisions related to the prerogatives of presidents and governments were frequently subject to political conflict during the 1990s. The power struggle in the two cases developed and consolidated along two distinct pathways. In Poland, failed attempts to modify the constitution initially stirred up and extended intra-executive conflicts. With the adoption of a new constitution in 1997 the struggle over power between president and council of ministers was finally settled. In Hungary constitutional court rulings were instrumental in the settlement of president–cabinet conflicts.     

Intimate Homicide and the Provocation Defence – Endangering Women? R v. Smith

This case note considers the availability in the United Kingdom of the provocation defence in cases of intimate homicide in the context of the recent House of Lords decision in Rv. Smith [2000] 3 W.L.R. 654. The note argues that the expansion of the objective component of the defence to encompass the mental infirmities of individual defendants is dangerous for women. Although it has the potential to help some abused women who kill to use the defence, it has, at the same time, exposed women who are abused by sexually possessive, violent men to even greater danger. It is thus argued that the defence should be restricted in the way envisaged by the minority judgement of Lord Millett so that abused women will still be able to use the defence, but by anon-medical route. Alternatively, the defence should be abolished and defences which pose no risk of encompassing violent men should be developed to accommodate abused women. This revised version was published online in July 2006 with corrections to the Cover Date.     

Tri-allelic SNP markers enable analysis of mixed and degraded DNA samples

For the analysis of degraded DNA in disaster victim identification (DVI) and criminal investigations, single nucleotide polymorphisms (SNPs) have been recognized as promising markers mainly because they can be analyzed in short sized amplicons. Most SNPs are bi-allelic and are thereby ineffective to detect mixtures, which may lead to incorrect genotyping. We developed an algorithm to find non-binary (i.e. tri-allelic or tetra-allelic) SNPs in the NCBI dbSNP database. We selected 31 potential tri-allelic SNPs with a minor allele frequency of at least 10%. The tri-allelic nature was confirmed for 15 SNPs residing on 14 different chromosomes. Multiplex SNaPshot™ assays were developed, and the allele frequencies of 16 SNPs were determined among 153 Dutch and 111 Netherlands Antilles reference samples. Using these multiplex SNP assays, the presence of a mixture of two DNA samples in a ratio up to 1:8 could be recognized reliably. Furthermore, we compared the genotyping efficiency of the tri-allelic SNP markers and short tandem repeat (STR) markers by analyzing artificially degraded DNA and DNA from 30 approximately 500-year-old bone and molar samples. In both types of degraded DNA samples, the larger sized STR amplicons failed to amplify whereas the tri-allelic SNP markers still provided valuable information. In conclusion, tri-allelic SNP markers are suited for the analysis of degraded DNA and enable the detection of a second DNA source in a sample.