Cerebral hypoxia and ischemia: the forensic point of view: a review

In cases with suspected brain anoxia/ischemia and hypoxia/hypoxemia a neuropathological investigation should give additional information to elucidate the cause of death and its pathophysiological mechanisms. Primary ischemic brain damage is associated with morphological and biochemical alterations. While acute ischemic neuronal injury reveals axon sparing and selective neuronal lesions due to the release of large quantities of glutamate, late neuronal death is associated with antiapoptotic growth factors, and decreased expression of microtubule-associated proteins and tubulin. On the morphological level ischemia can be detected by necrosis of neurons, proliferation of microglia, and astrocytes in vulnerable regions of the brain. In cases of permanent ischemia the so-called pale nervous cell injury is observed, in cases of partial perfusion the so-called dark nerve cell injury and apoptosis are detectable. In spite of the considerable advantages of recent research, presently there is no reliable qualitative marker to ascertain death due to acute hypoxic or ischemic events.     

Histological and immunohistochemical study of Wischnewsky spots in fatal hypothermia

Wischnewsky spots in the gastric mucosa are considered an important finding for the diagnosis of hypothermia-related deaths. In the present prospective histological and immunohistochemical investigation, 14 cases of fatal hypothermia presenting Wischnewsky spots at autopsy were studied. Macromorphologically, the lesions, varying in diameter from 0.1 to 0.4 cm, had a blackish-brownish color and appeared partly lofty, especially on the apex of gastric folds. Histologically, no erosions or ulcers were observed in the gastric mucosa. In some cases, hemorrhages in conjunction with infarctions of the mucosa were observed in the mucosal glands. Those regions, however, did not represent the lesions visible as Wischnewsky spots at the macroscopical level. Immunohistochemical stains were done with a specific antibody against hemoglobin (Dako, Glostrup, Denmark). Wischnewsky spots expressed immunopositivity with antihemoglobin. Concerning the pathogenesis and underlying pathophysiologic mechanisms contributing to the development of Wischnewsky spots, we hypothesize that cooling of the body in the setting of cold ambient temperatures primarily leads to circumscribed hemorrhages of the gastric glands in vivo or in the agonal period, respectively. Subsequently, due to autolysis, erythrocytes are destroyed and hemoglobin is released. Following exposure to gastric acid, hemoglobin is hematinized, leading to the typical blackish-brownish appearance of Wischnewsky spots seen at gross examination. Wischnewsky spots are not equivalent to erosions in terms of histopathological diagnosis but rather represent epiphenomena generated in vivo or in the agonal period of fatal hypothermia.     

Mediation as Signal

This paper analyzes mediation as a signal. Starting from a stylized case, a game theoretical model of one-sided incomplete information, taken from Cho and Kreps (1987), is applied to discuss strategic effects of mediation. It turns out that to reject mediation can be interpreted as a negative signal while the interpretation of accepting or proposing mediation is ambiguous and does not necessarily change the prior beliefs of the uninformed party. This asymmetry suggests that, in equilibrium, there is an excess of mediation.     

More on Ultimate and Immanent Justice: Results from the Research Project “Justice as a Problem within Reunified Germany”

In earlier studies it was shown that two domain-specific variates of belief in a just world, namely belief in immanent justice and belief in ultimate justice concerning severe illness, differ systematically and significantly. Only immanent justice leads to accusation and derogation of innocent victims while ultimate justice is concordant with positive evaluations of victims and helping behavior. With regard to the research project Justice as a Problem within Reunified Germany (GiP, from the German Gerechtigkeit als innerdeutsches Problem), two new scales were developed for purposes of measuring general belief in immanent and ultimate justice. Using a sample of 929 West Germans and 1,275 East Germans, some of the correlation patterns found in earlier studies could be replicated. For example, immanent justice did correlate with draconian judgments (the proneness to strict and severe judgments), while ultimate justice was associated with mildness. Only ultimate justice correlated with existential guilt about the underprivileged. Beside this confirmation of earlier findings, new correlation patterns were revealed. For example, only immanent justice correlated with the equity principle, whereas ultimate justice corresponded to the need and equality principles.     

Dimensions of democracies

Nomination: Arguments in favour of 'Democracies_—' by Manfred G. Schmidt, p.193
Reflections: Dimensions of democracy by Arend Lijphart, p.195     

Who wants the euro – and why? Economic explanations of public attitudes towards a single European currency

The paper looks at whether public attitudes towards a single European currency held in the European Union member states reflect a rational evaluation of the involved benefits and costs. It finds that they do: the looser monetary and fiscal policy was in the past, and the more time a country spent in the EMS, the more citizens welcome the euro. Attitudes towards the euro do not seem consistent with attitudes towards a European Central Bank, however. Upon closer scrutiny, opponents of a single currency appear to be less consistent and less rational in their responses than proponents.     

A Theoretical Note on the Differences Between Attitudes,Opinions, and Values

This theoretical note examines the concepts attitude, opinion, and value. It is argued that such acquired behavioral pre-dispositions are re-lated but have different conceptual foci and tend to address different phenomena. Although it is important to recognize their interconnected-ness, their indiscriminate use is likely to lead to messy theoretical ar-guments and misleading interpretations of empirical findings. This ar-ticle discusses key-aspects that need to be considered in the study of at-titudes, opinions, and values, as well as the relations between these.     

Political performance and types of democracy: Findings from comparative studies

Abstract. This essay explores the relationships between political performance profiles and major types of democracy from a comparative perspective. The article focuses attention mainly on the political performance of majoritarian and non-majoritarian government, democracies with small and large numbers of veto players, hybrid regimes, presidentialism and parliamentary government, referendum democracy and representative government, and established as apposed to partial democracies. The findings point to relatively robust and significant patterns of relationships between performance and type of democracy. Types of democracy are important constraints and represent at the same time enabling conditions of policy choices. However, a caveat must be added: types of democracy do not determine policy choices and they also do not determine the outcome of these choices.     

Voting on standardisation

This paper analyses equilibria of voting on commodity standards within the framework of a Farrell-Saloner model which takes into consideration the trade-off between network effects and losses from a reduction of variety. Social welfare implications are derived and discussed with respect to manipulations of majority rules. The findings indicate that welfare implications of standards are highly sensitive to the decision procedure and that the choice of the decision rule is non-trivial as it can at least prevent worst outcomes if not guarantee optimal results.