Confirmation by LC–MS of drugs in oral fluid obtained from roadside testing

The aim of this study was to assess the effectiveness of two current on-site oral fluid (OF) drug detection devices (OraLab and Dräger), as part of the Spanish participation in the Roadside Testing Assessment Project (ROSITA Project). The study was done in collaboration with the Spanish Traffic Police, in Galicia (NW Spain), during 2004 and 2005. A total of 468 drivers selected at the police controls agreed to participate through informed consent. In addition, saliva samples were collected and sent to the laboratory to confirm the on-site results. For this purpose, two different analytical liquid chromatography–mass spectrometry (LC–MS) methods were used to detect 11 drugs or metabolites in a 300 μL sample. Simultaneous analysis of morphine, 6-acetylmorphine, amphetamine, methamphetamine, MDA, MDMA, MDEA, MBDB, cocaine and benzoylecgonine was carried out using 100 μL of oral fluid, after an automated solid phase extraction. A different LC–MS method was performed to detect Δ⁹-THC in 200 μL of oral fluid using liquid–liquid extraction with hexane at pH 6. Both methods were fully validated, including linearity (1–250 ng/mL, 2–250 ng/mL) recovery (>50%), within-day and between-day precision (CV < 15%), accuracy (mean relative error < 15%), limit of detection (0.5 and 1 ng/mL), quantitation (1 and 2 ng/mL) and matrix effect. All of the positive cases and a random selection of 30% of the negatives were analyzed for confirmation analysis. Good results (sensitivity, specificity, accuracy, positive predictive value and negative predictive value > 90%) were obtained for cocaine and opiates by OraLab, and for cocaine by Dräger. However, the results for the other compounds could be improved for both detection devices. Differences in the ease of use and in the interpretation mode (visual or instrumental) were observed.     

Drinking from the Talent Pool: A Resource Endowment Theory of Human Capital and Agency Performance

This article advances a resource endowment theory of human capital and performance in government organizations. Building on research on human capital and firm location in business economics and task complexity in public management, the authors argue that an agency's ability to implement policy is determined both by its scale and by the human capital of the population from which it draws its employees. The authors cast labor as a factor of production in public agencies and argue that access to higher‐quality labor improves government effectiveness. The effect of human capital on performance is especially pronounced when agencies are charged with the implementation of technically complex tasks. The empirical subject is U.S. municipal water utilities’ compliance with the Safe Drinking Water Act. Comparing records of compliance with more and less complex regulatory requirements provides evidence consistent with the general model. The findings carry important implications for public management and policy design.     

Long-term effects of two childhood psychosocial interventions on adolescent delinquency,substance use,and antisocial behavior: a cluster randomized controlled trial

Objectives

Examine the long-term effects of two childhood universal prevention programs on adolescent delinquency, substance use, and antisocial behavior.

Methods

The cluster randomized controlled trial involved 56 schools and 1,675 children in Zurich, Switzerland. Two evidence-based interventions, namely the social-emotional skills program Promoting Alternative Thinking Strategies (PATHS) and the cognitive-behavioral parenting program Triple P, were implemented during the first two years of primary school, at ages 7 and 8 years. Outcomes were measured at ages 13 and 15 years, and included youth self-reports and teacher assessments. Multilevel models were used to account for the clustered nature of the interventions. Effects were estimated with the inclusion of baseline covariates.

Results

Across 13 outcomes related to delinquency, substance use, and antisocial behavior at ages 13 and 15 years, only two non-negligible effects were found. The first was a reduced prevalence of police contacts in the PATHS condition [effect size (ES)?=??0.225). The second was a difference in competent conflict resolution skills in the combined PATHS?+?Triple P condition compared to the context (ES?=?0.259), but in the unexpected direction: participants in the combined treatment appeared to be less competent than their control group peers. All other effects were either statistically non-significant or negligible in size (i.e., ES?<?|0.200|).

Conclusions

Even “evidence-based” interventions may have few long-term effects on delinquency, substance use, and antisocial behavior. Our findings add to the small literature on the long-term effectiveness of early universal prevention in field settings.

     

Y-chromosome STR-haplotype typing in El Salvador

Eight Y-chromosome STRs were investigated in a male population sample from El Salvador. Complete Y-chromosomal STRs haplotypes were obtained in 121 individuals, among which 107 different haplotypes were observed. The two most common haplotypes were shared by approximately 4% of the sample, while 100 haplotypes were unique. The gene diversity was 0.9883 and the discrimination capacity was 0.8926. The combined Y-chromosome STR polymorphisms provide a powerful discrimination tool for routine forensic applications.     

Early Childhood Predictors of Teen Dating Violence Involvement at Age 17

The distal relationship between risk factors in childhood and subsequent dating violence in late adolescence has not often been explored using longitudinal data. This study aims to shed light on the problem of dating violence by examining children’s backgrounds at age 7 and the link to the future involvement in dating violence at age 17 using the first and seventh waves of the Zurich Project on the Social Development from Childhood to Adulthood (z-proso, n?=?644). The sample consists of 644 multiethnic adolescents (57.14% female, M?=?17.47, SD?=?0.37), mainly Swiss-born (90%), though more than half of their parents (60%) were born in another country. A latent class analysis was applied to identify three different profiles (a) zero (or minimal) involvement in teen dating violence, (b) perpetrators/victims of controlling behaviors, and (c) perpetrators/victims of controlling behaviors and of physical violence. Participants who were corporally punished and/or victims of bullying at age 7 were significantly more likely to belong to the controlling and physical violence profile than children in the non-violent class. These results suggest a certain chronicity of the effects of violent experiences in early childhood on the patterns of romantic relationships at 17 years old.

     

Openness and the International allocation of foreign direct investment

This paper develops an ordinal index to measure the openness of FDI policy regimes for individual countries. There has been a generalised increase in the index between 1990 and 2002. The most important determinants of variations in FDI flows across countries and over time are country size, the level of educational achievement, and growth. The openness index is positively associated with FDI flows, but its explanatory power is low. Liberalising approval procedures and lifting requirements that foreign companies enter into joint ventures with domestic firms encourage FDI. We conclude that the openness of the FDI regime operates as a factor enabling FDI, but that location advantages are paramount in determining the international allocation of FDI. We also turn the question around and ask what countries are more likely to impose restrictions on FDI. We find that lower levels of education and larger domestic markets are associated with greater restrictions on FDI. In addition, there is some evidence that better institutions are associated with lower FDI restrictions.     

Relationship Between Intimate Partner Violence, Depressive Symptomatology, and Personality Traits

The aim of this study was to examine the relationship between intimate partner violence (IPV) and personality disorder symptoms controlling for depressive state. Victims of IPV (n?=?176) and non-abused women (n?=?193) completed the Dimensional Assessment of Personality Pathology-Basic Questionnaire (DAPP-BQ), Index of Spouse Abuse (ISA), and Beck Depression Inventory-II (BDI-II). IPV victims scored higher than non-abused women on Intimacy Problems, and scored lower on Rejection traits, after adjustment for depressive symptoms. Severity of the IPV was related to Cognitive Distortion, Suspiciousness, Restricted Expression, and Intimacy Problems, and the length of the IPV was negatively associated with Rejection. The current study suggests only modest differences in personality traits between IPV and non-abused women. The DAPP-BQ traits associated with severity of IPV, in a dose-response manner, would partially reflect the symptoms of complex post-traumatic stress disorder (CPTSD), although this possibility deserves further study.     

Severity of Psychological Maltreatment and Accumulative Risk for Psychopathology in Children of Mothers Exposed to Intimate Partner Violence

Psychological maltreatment (PM) is an extremely heterogeneous phenomenon that includes several subtypes. The aim of this work is to explore whether the accumulation of different subtypes of PM has a greater impact on the child’s psychopathology and functional impairment. One hundred and sixty-eight children and adolescents aged between 4 and 17 whose mothers had been exposed to intimate partner violence (IPV) participated. Psychopathology was assessed through a rating scale and a diagnostic interview. Polynomial contrasts by means of Generalized Estimated Equations explored linear and quadratic trends. The greater the number of PM subtypes suffered by children, the greater the adverse effects in psychopathology and functioning. When a child suffers four PM subtypes, the number of DSM disorders is, on average, twice as high compared with children who are suffering only one PM subtype. Linear trends were mainly found in internalizing problems. The importance of accurately assessing characteristics and severity of PM, and design efficient programs of prevention and treatment, is highlighted.