A case of fatal intoxication from metformin

A case of fatal intoxication from metformin is presented. The decedent was an obese 58-year-old-woman with type II diabetes, in whom severe lactic acidosis secondary to metformin accumulation was precipitated by acute renal failure. She had been on metformin 500 mg twice a day. Postmortem blood was deproteinated with acetonitrile, washed with dichloromethane, and the resulting supernatant injected into high-performance liquid chromatography system. Separation was performed on a analytical 125 x 4 mm i.d. RP-8 column. The wavelength was set at 235 nm. The mobile phase was acetonitrile (40%), sodium lauryl sulfate, and sodium dihydrogen phosphate adjusted to pH 5.1 (60%) at a flow rate of 1.0 mL/min. The concentration of metformin in postmortem blood was 77.3 microg/mL. The qualitative result was also confirmed by LC/APCI/MS/MS analysis.     

A new method of reproduction of fingerprints from corpses in a bad state of preservation using latex

In view of the problems arising while fingerprinting corpses in a bad state of preservation, especially in case of mummification and carbonization, the authors propose an innovative technique which uses latex film. To better illustrate the potential of the method, two cases where the latex technique was applied successfully are reported: the first one is a mummified body discovered in a shack on the outskirts of Milan and the second one is the case of a burnt corpse found in a car boot. Such a technique is versatile, easy to apply, and allows the operator to work quickly on cadavers without amputating parts, except in rare cases (i.e., burnt bodies with muscle retraction). By the latex technique, a perfect and enduring negative copy of the fingerprint is obtained, ready to be inked and photographed. The numerous copies produced this way can be inked several times allowing for the repeatability of the procedure and this is crucial in cases of problematic legal identification of corpses. In both the cases illustrated, the fingerprints obtained by the latex technique were useful for identification. The quality was good enough for the automatic fingerprint identification system research system to be applied.     

Delay of clinical manifestation and medical malpractice in a serious vascular complication of proximal locked tibial nailing

We are reporting on a case of complex lesion of the popliteal neurovascular bundle in a young woman, resulting from an operation for reduction and synthesis of a closed spiroid fracture of the mid-distal third of the left tibia by means of a Grosse-Kempf nail, with significant delay of clinical manifestation. Determining whether this is an "unavoidable complication" or "medical malpractice" is the target of the forensic investigation. In this case, the investigation leads to the conclusion that medical malpractice was the only explanation of the damage.     

Evidence of Haldol (haloperidol) long-term intoxication

A case of intoxication by haloperidol is reported. Haloperidol is a butyrophenone derivative commonly used in many hospital units as an antipsychotic agent. Adverse reactions due to haloperidol intoxication include drowsiness, blurred vision, extrapyramidal effects, tardive dyskinesia, tachycardia, hypotension and muscular rigidity. In August 2008, a 49 year-old female nurse started feeling various symptoms such as muscular rigidity, drowsiness and buccal dyskinesia. After 3 months, she was hospitalized for the worsening of these symptoms. Four months later, she showed once more the same symptoms. Two open water bottles from which the nurse used to drink in the hospital were confiscated and analyzed. Moreover, the nurse was asked to give a sample of her hair for executing the inherent toxicological analyses. Haloperidol was found in both bottles 1 and 2 at a concentration of 31.5 μg/mL and 43.6 μg/mL, respectively. Based on segmental hair analysis, it was deduced that the nurse consumed haloperidol in the approximate period from August 2008 to March 2009. The higher levels of haloperidol in hair were found in accordance with the periods of most severe appearance of symptoms, requiring the hospitalization of the nurse. The analysis of preservatives and excipients led us to conclude that the pharmaceutical drug was probably added to the water bottles as "Haldol 2mg/mL oral solution".     

Looking to the future: Prospective economic voting in 2008 Presidential Elections

Despite the economic turmoil of the time, a typical study of vote choice in the 2008 US Presidential Election would (falsely) find little evidence that voters’ opinions about the future state of the economy affected their vote choice. We argue that this misleading conclusion results from serious measurement error in the standard prospective economic evaluations survey question. Relying instead on a revised question, included for the first time in the 2008 American National Election Study, we find that most respondents condition their prospective economic evaluations on potential election outcomes, and that these evaluations are an important determinant of vote choice. A replication in a very different political context – the 2008 Ghanaian election – yields similar results.     

Machiavelli and the Problem of Dictatorship

Machiavelli is the first modern political thinker who pays great attention to the magistracy of dictatorship. “Dictatorial authority,” as he puts it, is fundamental to the survival and prosperity of republics: It is the magistracy, the “ordinary mode,” to which they turn to deal with “extraordinary accidents,” political and military emergencies. Machiavelli's gaze is cast both on the Ancient and the Modern world: Although he concentrates on the Roman magistracy, he also pays attention to magistracies of the modern world that were in some way similar, such as the Council of the Ten in the Republic of Venice. In my paper, I will attempt to reconstruct the essential points of Machiavelli's discussion on dictatorship; in the concluding remarks, I will briefly tackle the more general question of the relationship between politics and law in his work as a whole.     

Fundamental rights and private enforcement in the digital age

This article addresses the shift inthe paradigm of fundamental rights protection on the Internet. More and morethe enforcement of such rights is being delegated to private Internet operators, and the urgent question is how the task of balancing conflicting rights affects the status of Internet Service Providers (ISPs). The article examines the increasing privatisation of fundamental rights enforcementon the Internet, highlighting the impact of this trend. Following the analysisof recent developments, it argues that the pillars governing ISP liability should not be altered. In particular, the early determination that ISPs should not be presumptively saddled with content monitoring tasks should not be called into question. Therefore, the regulatory pressure on ISPs shouldbe lowered, as the spectre of liability, combined with ISPs' increasing role indeciding the proper balance between conflicting rights, unduly burdens the activity of ISPs and generates incentives to delete even lawful content.     

Ausgewählte Rechtsprobleme der Angelfischerei

Derzeit sehen sich Angler in Deutschland wiederholt und von unterschiedlicher Seite dem Vorwurf ausgesetzt, mit ihrem Hobby gegen das Tierschutzgesetz (TierSchG) zu versto?en. Im Wesentlichen stehen dabei zwei Angelpraktiken in der Diskussion, namentlich die Durchführung so genannter Gemeinschaftsfischen (dazu unter I.), sowie das Fangen und anschlie?ende Zurücksetzen zuvor geangelter Fische, so genanntes „Catch & Release“ (dazu unter II). Der Beitrag bezieht unter Berücksichtigung der Besonderheiten dieser Angelpraktiken, sowie unter Beachtung verfassungsrechtlichen Vorgaben – insbesondere von Art. 20 a GG – (dazu unter III.), Stellung zur aktuellen Rechtslage.     

Mere presence of informal guardians deters burglars: a virtual reality study

Journal of Experimental Criminology - This study investigates the deterrent effects of incremental levels of guardianship on residential burglary and assesses how burglars differ from non-burglars...