Determination of blood/serum ratios of different forensically relevant analytes in authentic samples

For forensic toxicological investigations only whole blood, but no serum is often available. Pharmacokinetic data are helpful for interpreting the results, but most of these studies indicate serum or plasma concentrations. In order to obtain reliable conversion factors which also take intersubject variability into account, the blood/serum ratios (B/S) of oxycodone, morphine, fentanyl, hydromorphone, zopiclone, MDMA, dexamphetamine, alprazolam, risperidone and 9-hydroxyrisperidone were determined by LC-MS/MS using authentic samples. Blood and corresponding serum samples were obtained from driving studies performed with controlled or known dosages of the above drugs. The analytes were analysed in blood and serum and the following mean B/S ratios (relative standard deviations) were determined: oxycodone 1.48 (8.19 %); morphine 1.03 (3.59 %); fentanyl 0.87 (13.9 %); hydromorphone 1.04 (8.11 %); zopiclone 0.89 (16.1 %); MDMA 1.19 (8.04 %); dexamphetamine 0.89 (10.9 %); alprazolam 0.81 (5.84 %); risperidone 0.65 (7.52 %); 9-hydroxyrisperidone 0.73 (12.3 %). These mean values are largely in line with those reported in the literature. The B/S ratios did not appear to depend on partition coefficients, whereas there was strong evidence that B/S ratios decreased with increasing plasma protein binding.     

Medical and legal aspects of genital mutilation and circumcision part I: female genital mutilation (FGM)

Female genital mutilation (FGM) is considered to be against the law and against morality not only in Western countries, although a woman of age and able to consent may sometimes think differently. The procedure may have serious physical and emotional consequences for the girl or woman. Nevertheless there are attempts to justify the procedure with medical and hygienic pseudoarguments, ideology, freedom of religion, cultural identity and social adequacy. Outside the Western world, some people claim that religion and culture alone justify the practice. In Germany, parents can lose the right to determine the residence of their daughter, if she is faced with the risk of genital mutilation in order to prevent that the child or girl is taken to her home country. Genital mutilation as a gender-specific threat is recognized as a reason to grant asylum or prevent deportation. Proposals to make genital mutilation a separate punishable offence are presently discussed by the legislator.     

Intracranial impalement with entrance site in the mandibular region: postmortem elucidation of an accidental fall on a wooden plant stick

A 78-year-old woman with a history of transient ischemic attacks was found in the doorway of her house in a somnolent and unresponsive condition. In the right mandibular region, a small skin wound was localized, which was surgically treated. Six days after admission to the hospital, an exploratory craniotomy was performed because of abnormal CT findings. Apart from tissue lesions and hemorrhages a small bone fragment was detected in the right cerebral cortex, which was removed. After 11 days in hospital, the patient died from failure of central regulatory functions. At the forensic autopsy, a 15 cm long wound track running upward from the skin wound in the right mandibular region through the bony skull base to the right parietal lobe of the brain was noted. Apparently, the surgically removed bone fragment had been displaced from the right middle cranial fossa. The site of the incident in the deceased's house was inspected again and a bamboo pole used to stabilize a potted plant standing on the floor was found and sent to the trace evidence laboratory. Analysis showed blood and tissue deposits from the victim. On the basis of all the findings and the circumstances of the case, a fatal impalement injury caused by an accidental fall could be assumed.     

Desorption atmospheric pressure photoionization-mass spectrometry in routine analysis of confiscated drugs

A comprehensive study was made, where desorption atmospheric pressure photoionization (DAPPI) was applied to the direct analysis of confiscated drugs and pharmaceuticals of various forms and matrices. The analyzed samples included herbal products [Catha edulis (khat), Psilocybe mushrooms, opium and Spice], designer drugs in tablet and powder form [e.g. meta-chlorophenylpiperazine (mCPP), 3-fluoromethamphetamine (3-FMA), methylenedioxypyrovalerone (MDPV) and methylone], and anabolic steroids in oil and tablets. The analyses were performed with ion trap mass spectrometer in MS and MS(2) modes and the obtained spectra were compared with GC-MS results. Contamination of the mass spectrometer was avoided by careful adjustment of the distance of the sample from the mass spectrometer inlet. DAPPI proved to be a fast and specific analysis technique, which does not require any sample preparation, and which therefore suits well to this type of forensic analysis.     

Globalization, welfare regimes and social protection expenditures in Western and Eastern European countries

This paper analyzes the effects of globalization on social protection expenditures in European countries. The particular focus is on (a) the Eastern European countries and (b) on differences in globalization effects between welfare regimes. We find evidence in favor of the compensation hypothesis in Western Europe which is driven by the conservative welfare regime, outweighing the efficiency effect of globalization in the social-democratic welfare regime. In Eastern European countries the efficiency effect is predominant. No globalization effect is found for the liberal and the southern welfare regimes.     

A Hitchhiker's Guide to the Public Administration Research Universe: Surviving Conversations on Methodologies and Methods

Scientific conversations can be riddled with confusion when contributions to the discussion are based on notions about ways of knowing that remain implicit. Researchers often mix different methodological positions in their research designs because they lack an awareness of the distinctions between different ways of knowing and their associated methods. The authors engage and reflect on these differences, with particular attention to four areas: research question formulations, the character and role of concepts and theories, hypotheses versus puzzles, and case study research. They call on all researchers, both academics and practitioners, to be aware of the ways in which scientific terms serve, in research debates, as signifiers of different logics of inquiry. Awareness of these differences is important for the sake of productive scientific discussions and for the logical consistency of research, as both of the ways of knowing discussed here are legitimate scientific endeavors, albeit invoking different evaluative criteria.     

Market making via regulation: The role of the state in carbon markets

Proponents as well as critics of carbon trading underestimate the institutional and political underpinnings of evolving carbon markets. Based on institutionalist approaches, this paper argues that the strong embeddedness of carbon markets explains why certain characteristics (positive and negative) materialize. Focusing on the actors who initiate and who influence carbon markets, this article also shows that currently only states and intergovernmental agreements provide the necessary regulation for carbon markets to exist and to work. Today, neither market actors nor NGOs nor public private partnerships have the political power to set up, regulate or capture evolving market structures. Thus, whether or not market‐based instruments bring about the desired results depends on good public regulation, which is – at least up to now – represented by the state. Four instances of the commodification of carbon serve as illustrations: the European Union Emission Trading System (EU ETS); the Clean Development Mechanism (CDM); the voluntary market; and new sectoral approaches, particularly Reducing Emissions from Deforestation and Degradation (REDD+).     

A developing context: Evaluation and FedNor's evolving institutional context

Context matters when understanding evaluation. This case study illustrates how the internal dynamics of the Federal Economic Development Initiative for Northern Ontario (FedNor) since 2008 were affected by evaluation priorities. Recent changes meant evaluation of FedNor programs focused on indicators of short‐term growth. This prompted a range of adaptive responses by actors within FedNor concerned with securing its developmental mandate, while meeting the requirements of evaluation.     

The Janus‐Face of Negociation Democracy. The Effects of Consensus Democracy,Direct Democracy and Decentralization on State Intervention in Swiss Cantons

Dieser Beitrag analysiert die Varianzen der quantifizierbaren Staatstätigkeit in den 26 Schweizer Kantonen der 1980er und 1990er Jahre. Im Mittelpunkt der erklärenden Grssen stehen dabei Formen der Verhandlungsdemokratie, insbesondere der Konkordanz, dezentraler Entscheidungsstrukturen und direktdemokratischer Beteiligungsrechte. Wir zeigen, dass die Erweiterung des Konzeptes der Verhandlungsdemokratie auf weitere Staatsorgane neben der Regierung zur analytischen Unschärfe fhrt, da die verschiedenen Ausprägungen der politischen Machtteilung mit unterschiedlichen Wirkungen auf den Umfang des ffentlichen Sektors verbunden sind. Während die Konkordanz im Sinne der parteifrmigen Organisation politischer und sozialer Konflikte tendenziell die staatliche Intervention begnstigt, zgeln konstitutionelle Vetospieler die Staatstätigkeit, indem direktdemokratische Mitwirkung und dezentrale Machtteilung dem Staat Fesseln auf der Einnahmen‐und Ausgabenseite anlegen.