Evaluation and applicability of Alere iCup DX 14 for rapid postmortem urine drug screening at autopsy

Performing point‐of‐care urine drug screen testing at autopsy by a forensic pathologist may provide an early indication of the presence of analytes of interest during autopsy. An evaluation for the screening of 14 classes of common drugs of abuse in postmortem urine by the point‐of‐care screening device, Alere iCup DX 14, is presented. One hundred ninety postmortem urine samples were screened with the iCup occurring at autopsy by the forensic pathologist. Positive and negative results obtained from the screening kit were evaluated against confirmatory test results obtained using routine forensic toxicology analyses that employed LC‐MS/MS and GC‐MS to detect a combination of over 85 common drugs of abuse and medications. Sensitivity for each respective iCup drug class ranged from 66% (buprenorphine) to 100% (methadone, tricyclic antidepressants). Specificity for each respective iCup drug class ranged from 89% (benzodiazepines) to 100% (amphetamines, barbiturates, buprenorphine, 3,4‐methylenedioxymethamphetamine, methadone). Positive predictive values ranged from 44% (benzodiazepines) to 100% (amphetamines, barbiturates, buprenorphine, methylenedioxymethamphetamine, methadone), while negative predictive values ranged from 96% (methamphetamine) to 100% (barbiturates, methadone, tricyclic antidepressants). A high false‐positive rate was yielded by the benzodiazepine class. The lack of fentanyl screening in the point‐of‐care device is a significant limitation considering its prolific prevalence in forensic casework. The results obtained in the study should be acknowledged when considering the use of the Alere iCup DX 14 in the context of postmortem casework to help indicate potential drug use contemporaneously with autopsy and when requiring such preliminary results prior to the release of a final forensic toxicology report.     

Plasma protein and red cell enzyme groups in Galicia (north west Spain)

Galactose-1-phosphate uridyl transferase (GALT), esterase D (EsD), and plasminogen (PLG) phenotypes were determined by isoelectric focusing in thin-layer polyacrylamide gels (PAGIF) in a random sample from Galicia. Haptoglobins (Hp) were determined by conventional electrophoresis. The following gene frequencies were observed: for GALT: GALTN: 0.930; GALTD1: 0.044; GALTD2: 0.025; for EsD: EsD1: 0.874; EsD2: 0.104; EsD3: 0.021; for PLG: PLG1: 0.800; PLG2: 0.199; for Hp: Hp1: 0.426; Hp2: 0.573. Population data results of all electrophoretic markers typed until now in Galician population are also included.     

Why Foundations Flourish: A Comparative Policy Framework to Understand Policy Support for Foundations across Countries*

Abstract

Philanthropic foundations have bloomed since the 1990s, contributing to the expansion of third sectors worldwide. This research aims to contribute to the comparative analysis of the policy conditions that shape the development – size and structure – of foundation fields across countries. A framework for comparative policy analysis encompassing key dimensions of policy support – policy milestones, levers, and alternatives – is proposed and applied to five southwestern European countries. Results demonstrate that although Spain, France, Italy, Belgium, and Portugal have been traditionally clustered under the same corporatist foundation model, their foundation fields vary widely in terms of size, structure and institutional embeddedness.     

Community Involvement as a Vehicle for Integration: A Study with Young Immigrants

ABSTRACT

Immigrants are often exposed to conditions of economic deprivation or to hardships of a social nature connected to their status. These factors increase their feeling of impotence, thus slowing down the integrative process. An element that could counter these disadvantaged conditions is participation in an association that promotes immigrants’ demands on a socio-political level. The first aim of this study is understanding the relationships between involvement and integration. The authors hypothesize that youth engaged in community are more integrated than not engaged immigrant youth. The second aim is to investigate the relationship between the type of activity, type of association and integration. The participants were 644 immigrant youth (Age range 19–35, 56.2%) that were involved in the community. The results show that involved immigrant youth report higher levels of both ethnic and national identity compared to not involved youth. Regarding the type of activity carried out, there is a statistically significant difference between activity of a social type, which obtains higher means, and of a civic type, which rather obtains lower means. While exploratory, the study shows and confirms the relationship between community engagement, young immigrants’ integration process and construction of identity.     

Ordinary Times in an Extraordinary Life

Every time I go back to Italy people ask me: "How does it feel living in China?" I know what they want to hear: Pollution is bad, the food is bad, the people are bad, but the pay is good. Instead I answer simply, "It’s normal." It really does feel normal. And it’s not     

Incentive effects of class actions and punitive damages under alternative procedural regimes

In an economic perspective, punitive damages and class actions can be viewed as sharing a common economic function—creating optimal deterrence. Building on Parisi and Cenini (Class actions for Europe: perspectives from law and economics, ELGAR, 2010), we study the effect of alternative procedural regimes on the effectiveness of punitive damages and class actions. Specifically, we compare the workings of punitive damages and class actions in the American and English (“loser-pays”) regimes. Our findings help explain the limited use and late adoption of class actions and punitive damages in Europe.