Field-portable detection of fentanyl and its analogs: A review

The need to detect fentanyl and its analogs in the field is an important capability to help prevent unintentional exposure or overdose on these substances, which may result in death. Many portable methods historically used in the field by first responders and other field users to detect and identify other chemical substances, such as hazardous materials, have been applied to the detection and identification of these synthetic opioids. This paper describes field portable spectroscopic methods used for the detection and identification of fentanyl and its analogs. The methods described are automated colorimetric tests including lateral flow assays; vibrational spectroscopy (mid-infrared and Raman); gas chromatography–mass spectrometry; ion mobility spectrometry, and high-pressure mass spectrometry. In each case the background and key details of these technologies are outlined, followed by a discussion of the application of the technology in the field. Attention is paid to the analysis of complex mixtures and limits of detection, including the required spectral databases and algorithms used to interrogate these types of samples. There is also an emphasis on providing actionable information to the (likely) non-scientist operators of these instruments in the field.     

Rapid enantiomeric analysis of zopiclone in serum by supercritical fluid chromatography–tandem mass spectrometry

Zopiclone (ZOP) is a hypnotic drug prescribed to treat insomnia. Due to the chiral nature of ZOP, the psychologically active S-form and inactive R-form need to be determined enantiomerically in a forensic drug analysis. In the present study, a supercritical fluid chromatography (SFC) method was designed with a faster analysis ability than that of previously reported techniques. The SFC–tandem mass spectrometry (SFC–MS/MS) method was optimized using a column with a chiral polysaccharide stationary phase (Trefoil CEL2). ZOP was extracted from pooled human serum using solid-phase extraction (Oasis HLB) and analyzed. The developed SFC–MS/MS method achieved the baseline separation of S-ZOP and R-ZOP within 2 min. The fit-for-purpose method validation indicated that the optimized solid-phase extraction achieved near complete recovery and approximately 70% of the matrix effect. Both the retention time and peak area showed sufficient precision. The lower and upper limits of quantification (LOQ) were 5.7 × 10⁻² ng/mL and 25 ng/mL for R-ZOP, and 5.2 × 10⁻² ng/mL and 25 ng/mL for S-ZOP. The calibration line was linear in the range from lower LOQ to upper LOQ. The stability test indicated that ZOP in serum stored in a refrigerator (4°C) degraded and about 55% remained in 31 days. The quick analysis of the SFC–MS/MS method makes it a valid option for the enantiomeric analysis of ZOP.     

Adult roles and the gender gap in political knowledge: a comparative study

The unusual size and persistence of the gender gap in political knowledge is perplexing in comparison to other dimensions of politics. Building on situational explanations of political engagement, this article claims that women’s and men’s specific adult roles lead to an enlargement of the gender gap in knowledge. The present study analyses men and women’s levels of political knowledge at different life stages by means of two unique datasets specifically collected to measure what people know about politics. Findings show that adult roles provide more opportunities for men to gain political knowledge than for women. Furthermore, the comparison of levels of political knowledge in two such dissimilar countries as Finland and Spain suggests that while gender equality policies are successful in tearing down some of the obstacles that hinder women’s contact with the political world, they are still insufficient to completely bridge the gender gap in political knowledge during adulthood.     

Who's Afraid of… Ethical Dilemmas in Qualitative Research

In the light of her latest study the author investigates ethical challenges of qualitative research connected to the issue of privacy and publicity. The value of any research is that its findings are recognizable to the informants. This is the presupposition of a dialogue and of a possible change of practice. This is, however, also the dilemma of anonymity. To make the analysis recognizable it is important that the steps are transparent, so that it is possible to follow the reasoning of the researcher. Visiting various researchers the author maintains that any research takes colour, not only of the researcher and the subjects, but also by the power games played on the scene. She underlines the responsibility of all parts to participate in an on‐going discussion of the result.     

First record of Hermetia illucens (Diptera: Stratiomyidae) on human corpses in Iberian Peninsula

This article presents the first record of Hermetia illucens larvae on a human corpse in Spain (the second case report in Europe). Prepupae of H. illucens, and other insects, were recovered from the dead body of a 72-year-old man in an advanced stage of decomposition. The body was located in Reus (NE Spain), in October 1998. This article provides additional biological data on experimental studies and an update on the geographic distribution of this species in the Iberian Peninsula.     

Economic vote instability: Endogeneity or restricted variance? Spanish panel evidence from 2008 and 2011

While the economic vote exists in Western democracies, the question of its stability remains a subject of controversy. This article focuses on two possible factors behind the instability observed: the endogeneity problem and the restricted variance problem. The former concerns the influence of partisan thinking on economic perception, while the latter concerns the influence of economic crisis, when virtually all voters may perceive a bad economy. These problems are examined using panel data from the Spanish national elections of 2008 and 2011. After various causality tests, it is concluded that the economic vote was influential in both contests, but apparently less so in 2011. It is shown in the article that the initial 2011 result misleads because of the statistical artifact presented by the restricted variance problem. Thus, an alternative strategy for exogenising economic perceptions is developed using aggregate economic measures in a pooled cross‐sectional design whereby it is demonstrated that the economy mattered greatly under the economic crisis of 2011. This estimation strategy could be applicable to other Western democracies experiencing such economic crisis.