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81.
Hiroki Segawa PhD Yuko T. Iwata PhD Yuki Okada MS Tadashi Yamamuro PhD Kenji Kuwayama PhD Kenji Tsujikawa PhD Tatsuyuki Kanamori PhD 《Journal of forensic sciences》2023,68(4):1352-1358
Zopiclone (ZOP) is a hypnotic drug prescribed to treat insomnia. Due to the chiral nature of ZOP, the psychologically active S-form and inactive R-form need to be determined enantiomerically in a forensic drug analysis. In the present study, a supercritical fluid chromatography (SFC) method was designed with a faster analysis ability than that of previously reported techniques. The SFC–tandem mass spectrometry (SFC–MS/MS) method was optimized using a column with a chiral polysaccharide stationary phase (Trefoil CEL2). ZOP was extracted from pooled human serum using solid-phase extraction (Oasis HLB) and analyzed. The developed SFC–MS/MS method achieved the baseline separation of S-ZOP and R-ZOP within 2 min. The fit-for-purpose method validation indicated that the optimized solid-phase extraction achieved near complete recovery and approximately 70% of the matrix effect. Both the retention time and peak area showed sufficient precision. The lower and upper limits of quantification (LOQ) were 5.7 × 10−2 ng/mL and 25 ng/mL for R-ZOP, and 5.2 × 10−2 ng/mL and 25 ng/mL for S-ZOP. The calibration line was linear in the range from lower LOQ to upper LOQ. The stability test indicated that ZOP in serum stored in a refrigerator (4°C) degraded and about 55% remained in 31 days. The quick analysis of the SFC–MS/MS method makes it a valid option for the enantiomeric analysis of ZOP. 相似文献
82.
Massimiliano Andretta 《South European society & politics》2018,23(1):97-114
AbstractUsing protest event analysis methodology and conceptual and theoretical toolkits developed in social movement studies, this article analyses protest mobilisation during the period of the height of the economic crisis in Italy (2009–2014) by comparing the protest trends in diachronic and comparative perspectives over a period of four different governments. Data show that the Italian anti-austerity protest arena was dominated by ‘old actors’ (the traditional trade unions) and was not able to produce the strong social and political coalitions that emerged in other South European countries. This was due to the specific relationship that developed between civil society and political parties that shaped the forms of anti-austerity mobilisation in this period. 相似文献
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Bradley J. Adams PhD Erin Butler MS Stephanie M. Fuehr MA Fransheska Olivares-Pérez MS Alexandra Semma Tamayo MSc 《Journal of forensic sciences》2024,69(2):391-399
Age estimation is an important component of decedent identification. When assessing adult remains, anthropologists frequently use gross examination of skeletal elements, such as clavicles, ribs, and pubic symphyses. For fleshed bodies, this requires the removal of these elements and maceration prior to analysis. A new method was developed using radiographic imaging to estimate age from degenerative changes of the lower thoracic and upper lumbar vertebrae. This technique will complement anthropological age estimation methods in young and middle-aged adults and may serve as a stand-alone method for older individuals. Digital radiographs from 240 medical examiner cases were evaluated. The sample included 120 females and 120 males between the ages of 18 and 101 years. A 3-phased scoring system was used for the target vertebrae. Transition analysis was conducted on binned average scores and a Bayesian approach was used to assign age intervals. At the 90% credible interval, individuals in Bin 1 were under 36 years of age while those in Bin 3 were over 47 years of age. Individuals in Bin 2 showed too much age variation to be informative. No significant differences were found between males and females. These findings will be especially useful in the age estimation of older adults and may eliminate the need for skeletal sampling in medicolegal cases where advanced degenerative changes are radiographically observed in the lower thoracic and/or upper lumbar vertebrae. This method was developed for use on fleshed individuals but may also be applicable to skeletonized remains. 相似文献
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Colombo Massimo G. Guerini Massimiliano Rossi-Lamastra Cristina Bonaccorsi Andrea 《The Journal of Technology Transfer》2022,47(1):270-306
The Journal of Technology Transfer - This paper studies the collaborations between entrepreneurial ventures and universities by investigating the “first match”, namely, the probability... 相似文献
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The Enhanced Cognitive Interview (ECI) is one of the most useful witness interviews, consisting of 5 techniques (context reinstatement: CR; report everything: RE, mental imagery: MI, change order: CO and change of perspectives: CP) aimed at increasing both the quantity and the quality of elements recalled. All the techniques require mental imagery skills. The present study investigates the relationship between forward and backward visuo-spatial working memory (VSWM) and correct elements recalled through the ECI with respect to its techniques. 99 college students (48 males) watched a color videotape of a fictional crime and performed a visuo-spatial working memory task. The following day they were interviewed about what they had seen. Results showed that high forward VSWM capacity has a role in favoring the total amount of correct information recalled, specifically in the MI technique. This suggests that maintaining and processing mood-related contents in VSWM is easier for individuals with high working memory skills. 相似文献