Prolonged QT interval and sudden infant death--report of two cases

In the two cases where infants died suddenly and unexpectedly the electrocardiogram (ECG) of a younger sibling (case 1) and of a living twin (case 2) led to the suspicion that the two infants could have died from long QT syndrome (LQTS). In case 1, a His bundle (HB) dispersion and a pronounced hypoplasia of the right external nucleus arcuatus were detected. In case 2, a severe interstitial pneumonia and an accompanying mild myocarditis were found by histology. Molecular genetic investigations of the coding regions of the genes, HERG, KVLQT1 and SCN5A gave no indication for the mutations, thus, affecting related myocardial ion channels as possible sources of inhomogeneity of repolarisation.Since a molecular genetic deviation could not yet be elaborated the possible role of related disturbance remains unknown.     

Somatic mutations at STR loci--a reason for three-allele pattern and mosaicism

Two families are analysed in which one of the parents exhibited a three-allele pattern at the ACTBP2 locus. Since the alleles were obviously segregated independently to the children, a generalised mosaicism must be assumed involving at least two tissues in one of them and at least four tissues in the other one. The intensity of the PCR amplified alleles in both three-allele individuals indicate an occurrence in a very early embryonic stage. Occurrence was most probably due to a single step mutation in both cases. Forensic implications would include paternity testing as well as stain analysis.     

Civil society and the European common security and defence policy

The involvement of civil society organizations (CSOs) is widely regarded by students of the EU's domestic policy fields as enhancing transparency and accountability and, more generally, the democratic quality of political processes. This article explores the contribution of CSOs to the EU's Common Security and Defence Policy and assesses whether a democracy-enhancing effect of their involvement can also be demonstrated for this policy field. We analyse the contribution of CSOs based on two common models of democracy: the intergovernmental and the supranational model of democracy. We find that CSOs are indeed quite actively involved in the EU's security policy. With regard to their democracy-enhancing effects, however, our findings are rather mixed. While the engagement of CSOs does provide a remedy for the democratic deficits associated with intergovernmental decision-making, these organizations do not fully meet the demands posed by supranational governance.     

Do Religious Factors Impact Armed Conflict? Empirical Evidence From Sub-Saharan Africa

Theoretically, the “mobilization hypothesis” establishes a link between religion and conflict by arguing that particular religious structures are prone to mobilization; once politicized, escalation to violent conflict becomes more likely. Yet, despite the religious diversity in sub-Saharan Africa and the religious overtones in a number of African conflicts, this assumption has not yet been backed by systematic empirical research on the religion–conflict nexus in the region. The following questions thus remain: Do religious factors significantly impact the onset of (religious) armed conflict? If so, do they follow the logic of the mobilization hypothesis and, if so, in which way? To answer these questions, this article draws on a unique data inventory of all sub-Saharan countries for the period 1990–2008, particularly including data on mobilization-prone religious structures (e.g., demographic changes, parallel ethno-religious identities) as well as religious factors indicating actual politicization of religion (e.g., inter-religious tensions, religious discrimination, incitement by religious leaders). Logit regressions suggest that religion indeed plays a significant role in African armed conflicts. These findings are compatible with the mobilization hypothesis, and stress the impact of conflict-prone religious structures, and particularly, the fact that overlaps of religious and ethnic identities are conflict-prone. Future research should investigate the religion-ethnicity-nexus in more detail.     

From the national state to the rational state and back? An exercise in understanding politics and identity in Germany in the twentieth century

The end of the East‐West conflict and the unification of Germany in 1990 have dramatically altered the geopolitical shape of Europe. Speculations abound, in particular as regards Germany: have the spectres of German nationalism been banished for good? Is the new Berlin Republic different from the Bonn Republic? This article traces the national idea in Germany since the early nineteenth century and argues that the Bonn years have been crucial in the development of a civic culture which transcends the concept of a nation dominant in Germany from 1871 to 1945. Rather than marking a return of traditional nationalist concepts, the unification of Germany may well open the way for a lasting reorientation towards a civic concept of national identity in Germany.     

Ultrastructural pathology of the alveolar apparatus in experimental drowning

Investigations were carried out on anaesthetized rats which by a tracheotomy tube actively aspirated liquids of different osmolarities covering a range from tap water to 2.9% NaCl solution. In every range of osmolarity, the ultrastructural alterations show areolar limitations and different stages of development. In freshwater the influx of liquid causes a hypoxemic-dysoric alveolose with diffuse of pulvinate oedematous swellings of all compartments of the blood-gas-barrier, cytolysis, karyolysis, membrane desintegration, hydropic alterations of the (cell) organelles, dilatation of the drainage tracts of the alveolar interstitium. Vesicular transformation caused by a dilatation of the pinocytotic system ending in endothelial and epithelial vesiculation. Salt-water drowning leads to a hypoxemic alveolose with a marked compaction of the matrix. The epithelium shows many alterations of the surface, numerous protrusions, constrictions and expose of the basement membrane (villous transformation). Erythrocyte sludge and thorn-apple-shaped erythrocytes are found in the capillaries. Application of electron microscopy in the diagnosis of drowning allows a more reliable classification and, correspondingly, decisive improvements of the reliability of lightmicroscopical findings.