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Netherlands International Law Review - This article examines the use by the US of drone strikes in regions described as ‘outside areas of active hostilities’ a phrase that appears to... 相似文献
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Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial
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Dustin Albert Daniel W. Belsky D. Max Crowley Shawn J. Latendresse Fazil Aliev Brien Riley Cuie Sun Conduct Problems Prevention Research Group Danielle M. Dick Kenneth A. Dodge 《Journal of policy analysis and management》2015,34(3):497-518
Early interventions are a preferred method for addressing behavioral problems in high‐risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10‐year‐long intervention to prevent high‐risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European‐American children, a variant of NR3C1 identified by the single‐nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African‐American children. We discuss implications for efforts to prevent externalizing problems in high‐risk children and for public policy in the genomic era. 相似文献
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John Young 《Diplomacy & Statecraft》2003,14(2):295-324
This article investigates the claim of Britain's Prime Minister, Harold Wilson, to have 'killed' the Multilateral Force, an attempt to bring about nuclear sharing within NATO and answer the supposed German desire for equality of status. Earlier accounts have often seen the Multilateral Force as being abandoned, largely thanks to shifts in American policy, in late 1964. The case argued here is that the proposal continued to tax the alliance well into 1966, that important elements in the American and German governments continued to support it and that the British do deserve some credit for bringing the whole idea to an end. In particular the launch of an alternative proposal (the 'Atlantic Nuclear Force'), Wilson's readiness to argue with Washington and Bonn, and the exploitation of French withdrawal from NATO in 1966 proved important, even if British opposition was only one of several factors working against nuclear sharing. In the process he was also able to neutralise the dangers posed to him in the domestic political sphere by the debate over nuclear weapons. 相似文献
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